scholarly journals Investigating the impact of target lesion selection on drug effect evaluation and tumour growth rate determination using tumour growth inhibition models: example of malignant pleural mesothelioma patients treated with cisplatin alone or in combination with pemetrexed

2021 ◽  
pp. 105781
Author(s):  
Aurélie Lombard ◽  
Hitesh Mistry ◽  
Sonya C. Chapman ◽  
Ivelina Gueorguieva ◽  
Leon Aarons ◽  
...  
Keyword(s):  
Growth Rate ◽  
Growth Inhibition ◽  
Tumour Growth ◽  
Drug Effect ◽  
Target Lesion ◽  
Pleural Mesothelioma ◽  
Effect Evaluation ◽  
Tumour Growth Inhibition ◽  
The Impact ◽  
Tumour Growth Rate

scholarly journals Monocytes mediate Salmonella Typhimurium‐induced tumour growth inhibition in a mouse melanoma model

2021 ◽  
Author(s):  
Síle A. Johnson ◽  
Michael J. Ormsby ◽  
Hannah M. Wessel ◽  
Heather E. Hulme ◽  
Alberto Bravo‐Blas ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Salmonella Typhimurium ◽  
Tumour Growth ◽  
Mouse Melanoma ◽  
Mouse Melanoma Model ◽  
Melanoma Model ◽  
Tumour Growth Inhibition

scholarly journals When, why and how clonal diversity predicts future tumour growth

2019 ◽  
Author(s):  
Robert Noble ◽  
John T Burley ◽  
Cécile Le Sueur ◽  
Michael E Hochberg
Keyword(s):  
Growth Rate ◽  
Tumour Growth ◽  
Evolutionary Process ◽  
Clonal Diversity ◽  
Driver Mutations ◽  
Multiple Cancer ◽  
Intratumour Heterogeneity ◽  
Cancer Types ◽  
The Relationship ◽  
Tumour Growth Rate

AbstractIntratumour heterogeneity holds promise as a prognostic biomarker in multiple cancer types. However, the relationship between this marker and its clinical impact is mediated by an evolutionary process that is not well understood. Here we employ a spatial computational model of tumour evolution to assess when, why and how intratumour heterogeneity can be used to forecast tumour growth rate, an important predictor of clinical progression. We identify three conditions that can lead to a positive correlation between clonal diversity and subsequent growth rate: diversity is measured early in tumour development; selective sweeps are rare; and/or tumours vary in the rate at which they acquire driver mutations. Opposite conditions typically lead to negative correlation. Our results further suggest that prognosis can be better predicted on the basis of both clonal diversity and genomic instability than either factor alone. Nevertheless, we find that, for predicting tumour growth, clonal diversity is likely to perform worse than conventional measures of tumour stage and grade. We thus offer explanations – grounded in evolutionary theory – for empirical findings in various cancers. Our work informs the search for new prognostic biomarkers and contributes to the development of predictive oncology.

scholarly journals Magnetic nanoparticle-mediated hyperthermia therapy induces tumour growth inhibition by apoptosis and Hsp90/AKT modulation

2015 ◽  
Vol 31 (8) ◽  
pp. 909-919 ◽  
Author(s):  
Neena G. Shetake ◽  
Amit Kumar ◽  
Snehal Gaikwad ◽  
Pritha Ray ◽  
Sejal Desai ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Magnetic Nanoparticle ◽  
Tumour Growth ◽  
Hyperthermia Therapy ◽  
Tumour Growth Inhibition

Ki67 in the Assessment of Tumour Growth Rate: A Study on Xenografts

1989 ◽  
Vol 56 (5) ◽  
pp. 797-800 ◽  
Author(s):  
P. Price ◽  
C. Bush ◽  
C.S. Parkins ◽  
P. Imrie ◽  
M.G. Ormerod ◽  
...  
Keyword(s):  
Growth Rate ◽  
Tumour Growth ◽  
Tumour Growth Rate

scholarly journals Morphology of Human Glioblastoma Model Cultured in Ovo

2012 ◽  
Vol 56 (2) ◽  
pp. 261-266 ◽  
Author(s):  
Maciej Szmidt ◽  
Kaja Urbańska ◽  
Marta Grodzik ◽  
Piotr Orłowski ◽  
Ewa Sawosz ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Growth Inhibition ◽  
Tumour Growth ◽  
Molecular Mechanisms ◽  
Chorioallantoic Membrane ◽  
Structural Features ◽  
Future Research ◽  
In Ovo ◽  
Tumour Growth Inhibition ◽  
Novel Model

Abstract The aim of this study was the morphological characterisation of glioblastoma multiforme tumour grown in ovo. Tumour cells (U-87 MG) were implanted on the chorioallantoic membrane of chicken egg. The structural features of cultured tumours resembled the spontaneous glioblastoma multiforme; however, the differences were also indicated. Our results confirm applicability of in ovo culture in tumour genesis studies. The described novel model may be profoundly helpful for the future research on molecular mechanisms of tumour growth inhibition.

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