Exploring the systemic delivery of a poorly water-soluble model drug to the retina using PLGA nanoparticles

2021 ◽  
pp. 105905
Author(s):  
Enqi Zhang ◽  
Nadezhda Osipova ◽  
Maxim Sokolov ◽  
Olga Maksimenko ◽  
Aleksey Semyonkin ◽  
...  
Keyword(s):  
Plga Nanoparticles ◽  
Water Soluble ◽  
Systemic Delivery ◽  
Soluble Model ◽  
Poorly Water Soluble ◽  
Model Drug

scholarly journals Stabilization benefits of single and multi-layer self-nanoemulsifying pellets: A poorly-water soluble model drug with hydrolytic susceptibility

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0198469
Author(s):  
Ahmad Abdul-Wahhab Shahba ◽  
Fars Kaed Alanazi ◽  
Sayed Ibrahim Abdel-Rahman
Keyword(s):  
Water Soluble ◽  
Soluble Model ◽  
Poorly Water Soluble ◽  
Model Drug

Comparison of nanomilling and coprecipitation on the enhancement ofin vitrodissolution rate of poorly water-soluble model drug aripiprazole

2013 ◽  
Vol 19 (4) ◽  
pp. 491-500 ◽  
Author(s):  
Aly A. Abdelbary ◽  
Xiaoling Li ◽  
Mohamed El-Nabarawi ◽  
Abdelhalim Elassasy ◽  
Bhaskara Jasti
Keyword(s):  
Water Soluble ◽  
Soluble Model ◽  
Poorly Water Soluble ◽  
Model Drug

PH Solubility Properties and Improved Dissolution of Pranlukast as an Poorly Water-soluble Model Drug Prepared by Spray-drying with Plasdone S-630

Polymer Korea ◽  
2011 ◽  
Vol 35 (4) ◽  
pp. 277-283
Author(s):  
Won Hyung Cho ◽  
Young Hyun Lee ◽  
Byung Joo Song ◽  
Seok Cheol Yoo ◽  
Dong Kyun Lim ◽  
...  
Keyword(s):  
Spray Drying ◽  
Water Soluble ◽  
Soluble Model ◽  
Poorly Water Soluble ◽  
Model Drug

Controlled Release of Tablets Containing Poorly Water Soluble Model Drug Coated with Kollicoat MAE 30DP

2011 ◽  
Vol 418-420 ◽  
pp. 2186-2189
Author(s):  
Stefan Lemke ◽  
Mont Kumpugdee-Vollrath
Keyword(s):  
Film Surface ◽  
Water Soluble ◽  
Coating Film ◽  
Intestinal Fluid ◽  
Colon Delivery ◽  
Soluble Model ◽  
Wavy Structure ◽  
Poorly Water Soluble ◽  
Model Drug ◽  
Ph Sensitive Polymer

In this project we have prepared the tablets with a coating of pH-sensitive polymer Kollicoat MAE 30DP. For this purpose the core tablets prepared from poorly water soluble model drug and other excipients were coated by a fluidized bed apparatus at the exhaust air temperature of 30°C and spraying rate of 0.55 g/min. The highest coating time was 384 min which leads to the film thickness of 648 µm. The coated tablets were gastric resistant for one hour and resistant against intestinal fluid pH 6.8 up to 70 min. The coating film has a good quality with smoothness and dense packing. However, if the thickness was high e.g. 600 µm the film surface had more wavy structure. The results served to formulate the colon delivery system.

EFFECT OF CROSSLINKER AMOUNT ON HYBRID HYDROGELS SWELLING AND DRUG RELEASE

2021 ◽  
Author(s):  
Maja Markovic ◽  
◽  
Vesna Panic ◽  
Julijana Tadic ◽  
Rada Pjanovic
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Water Soluble ◽  
Soluble Model ◽  
Hybrid Hydrogels ◽  
Poorly Water Soluble ◽  
Targeted Drug ◽  
Model Drug

Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficient therapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly water- soluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based on poly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pH sensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAA can only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous research was directed towards overcoming this limitation: PMAA was modified with amphiphilic protein – casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study is focused on investigation how variation of amount of one of the most important hydrogels network parameter such as crosslinker affect PMAC swelling properties and caffeine release. The group of hybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%, 1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels and caffeine release was investigated in two environments which simulated human stomach and intestines. Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved and that its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can be easily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential for targeted delivery of poorly water-soluble active substances.

Investigation of Nanoscale Structure of Self-Emulsifying Drug Delivery System Containing Poorly Water-Soluble Model Drug

2014 ◽  
Vol 970 ◽  
pp. 272-278 ◽  
Author(s):  
Mont Kumpugdee-Vollrath ◽  
Yotsanan Weerapol ◽  
Karin Schrader ◽  
Pornsak Sriamornsak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Correlation Spectroscopy ◽  
Water Soluble ◽  
Wide Range ◽  
Poorly Water Soluble ◽  
Nanoscale Structure ◽  
Model Drug ◽  
20 Nm

This work has a focus on the self-emulsifying drug delivery system (SEDDS), which can be used in pharmaceutical field for increasing bioavailability of poorly water-soluble drugs. The model drug resveratrol was used because of its poor water-solubility and is of interest because of its wide range of pharmacological effects. It is beneficial to understand the mechanism of SEDDS formation in the human body, therefore, the determination of nanoscale structure was carried out. For this purpose, small angle X-ray scattering (SAXS), photon correlation spectroscopy (PCS), and transmission electron microscopy (TEM) techniques were applied. We have found that the size and size distribution of particles were in nanometers. The inner structure of SEDDS was ordered with the lamellar distances (d-spacing) of < 20 nm. It seems that the prepared SEDDS in water form large oil drops (200-400 nm) in water as well as small micelles with the droplet size of 10-20 nm.

scholarly journals Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats

2019 ◽  
Vol 56 (3) ◽  
pp. 520-534
Author(s):  
Daniela Miricescu ◽  
Alexandra Totan ◽  
Iulia Ioana Stanescu ◽  
Andreea Didilescu ◽  
Ruxandra Sfeatcu ◽  
...  
Keyword(s):  
Vitamin E ◽  
Wistar Rats ◽  
Plga Nanoparticles ◽  
Water Soluble ◽  
Control Group ◽  
Daily Dose ◽  
Total Antioxidant ◽  
Poorly Water Soluble ◽  
Hypercaloric Diet ◽  
Hepatic Level

The hypercaloric diet leads to obesity which is a risk factor for developing many systemic diseases such as diabetes, cardiovascular diseases and cancer. The purpose of our study was to observe the antioxidants effects of entrapped alfa-tocopherol (vitamin E) and lutein in Poly Lactic-CO-Glycolic acid (PLGA) in Wistar rats that received 3 weeks hypercaloric diet. Hepatic and splenic lysates have been used to detect changes in total antioxidant capacity (TAC) and advanced oxidative protein products (AOPP). The AOPP liver levels were statistically decreased in the case of rats groups that received a daily dose of PLGA-lutein or PLGA-vitamin E versus the control group. The AOPP level was decreased but statistically insignificant in Wistar rats spleen who received a daily dose of PLGA-lutein. At hepatic level, TAC was statistically increased in rats groups that received a daily dose of vitamin E or lutein. An increased statistical level of TAC was observed in the spleen cell lysing in Wistar rats who received the daily dose of PLGA-vitamin E. Entrapment of vitamin E and lutein in PLGA structure has diminished the effects of hypercaloric diet and can be considered a attractive and promising approach to enhance the bioavailability and activity of poorly water soluble compounds.

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