scholarly journals Body composition and basal metabolic rate in systemic lupus erythematosus patients

2017 ◽  
Vol 39 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Z. Shamekhi ◽  
Z. Habibagahi ◽  
M. Ekramzadeh ◽  
Ata Ghadiri ◽  
F. Namjoyan ◽  
...  
2018 ◽  
Vol 11 (1) ◽  
pp. 63
Author(s):  
Faiq I. Gorial ◽  
Zainab A. Mahmood ◽  
Sundus Al Obaidi

BACKGROUND & OBJECTIVE: SLE is one of systemic diseases, targeting young patients, so we try to study the one of factors that affected these patients. The aim of our study is to describe the body composition in Iraqi lupus patients, and assess the effect of the disease activity, disease duration, treatment, and patients’ social class in development of sarcopenia. PATIENTS & METHOD: Sixty women, age > 18years with SLE and 56 matched controls were studied. Disease activity measured by systemic lupus erythematosus disease activity index, and functional status measured by systemic lupus erythematosus quality of life questionnaire. Body mass index, waist circumference measured for patients and controls. Body composition analyzed by dual energy absorptiometry x-ray. RESULTS: Mean age for patients was 31.75±10.06 years, and mean disease duration was 19.62±10.76 months. No differences in body mass index, central obesity, lean mass percentage, fat mass percentage, appendicular lean mass index, and bone mineral density between patients and controls. Z score was lower in lupus patients as compared with controls (-1.61±0.8 for patients, -1.26±0.71 for control, p= 0.013). Treatment with azathioprine found to decrease the risk of sarcopenia (p= 0.046). Medical social class and working social class show lower risk for sarcopenia compared to unemployed class (p= 0.003, 0.002 respectively). However disease duration, disease activity, using prednisolone, and functional status had no effect. CONCLUSIONS: No significant differences in body mass index, fat mass percentage, lean mass percentage, and appendicular lean mass index in lupus patients and controls. Lupus patients have higher risk to loss their bone density.


Rheumatology ◽  
1999 ◽  
Vol 38 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Y. Kipen ◽  
E. M. Briganti ◽  
B. J. Strauss ◽  
G. O. Littlejohn ◽  
E. F. Morand

2007 ◽  
Vol 36 (1) ◽  
pp. 40-47 ◽  
Author(s):  
V. Lilleby ◽  
M. Haugen ◽  
L. Mørkrid ◽  
Frey K. Frøslie ◽  
K. B. Holven ◽  
...  

2014 ◽  
Vol 307 (8) ◽  
pp. R990-R997 ◽  
Author(s):  
Emily L. Gilbert ◽  
Michael J. Ryan

Because of the preponderance of women affected by the chronic autoimmune disease systemic lupus erythematosus (SLE), estrogen is thought to contribute to SLE disease progression. This is supported by evidence from experimental animal models of SLE showing that removal of estrogen in young female mice delays autoantibody production and renal injury and lengthens survival. Blood pressure and changes in body composition are important cardiovascular risk factors that can be regulated by estrogens. Because cardiovascular disease is the leading cause of death in patients with SLE, we used an established female mouse model of SLE (NZBWF1) to test whether early life removal of estrogen impacts the development of hypertension and changes in body composition commonly associated with SLE. Eight-week-old female SLE and control mice (NZW/LacJ) underwent either a sham operation or ovariectomy. Body weight, body composition (fat and lean masses), and renal injury (albuminuria) were monitored until mice reached 34 wk of age, at which time mean arterial pressure was assessed in conscious animals by a carotid catheter. Early life removal of the ovaries delayed the onset of autoantibody production and albuminuria while causing an increase in body weight and fat mass. Blood pressure in the adult was not altered by early life removal of the ovaries. These data suggest that estrogens may have a permissive role for the development of SLE while helping to maintain normal body weight and composition, which is associated with reduced cardiovascular risk.


1999 ◽  
Vol 42 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Naoya Komatsu ◽  
Kazuhiro Kodama ◽  
Naoto Yamanouchi ◽  
Shin-ichi Okada ◽  
Shingo Noda ◽  
...  

2012 ◽  
Vol 5 (3) ◽  
pp. 118-121
Author(s):  
C.J. Borba-Pinheiro ◽  
N.M. Almeida de Figueiredo ◽  
A. Walsh-Monteiro ◽  
M.C. Gurgel de Alencar Carvalho ◽  
A. Janotta Drigo ◽  
...  

Rheumatology ◽  
1998 ◽  
Vol 37 (5) ◽  
pp. 514-519 ◽  
Author(s):  
Y. Kipen ◽  
B. J. Strauss ◽  
E. F. Morand

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