81. Bridging the age gap in breast cancer interim analysis of the impact of comorbidity, dementia and frailty on rates of surgery in older women

The 2010–2015 Conservative-led Coalition’s austerity policies hit women financially harder than men. However, contrary to expectations at the time, the Conservatives still gained more support from women than men on average in the 2015 general election. We examine the impact of austerity on vote choice in the 2015 and 2017 general elections through analysis of Labour and Conservative economic policy in conjunction with data from the British Election Study’s face-to-face post-election surveys. The expectation that women should be particularly anti-austerity and thus less supportive of the Conservative Party does hold for younger women, who were especially pessimistic relative to their male peers and older age groups about their living costs, household finances, the economy, and the National Health Service in both elections. However, this does not hold for older women, who were protected by the Coalition’s policies on pensions and were more similar to men in their assessment of their economic situation.

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Impact of dementia on treatment of older patients with breast cancer. An interim analysis of the bridging the age gap in Breast Cancer Study

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2016.07.068 ◽

2016 ◽

Vol 42 (11) ◽

pp. S232-S233

Author(s):

Osama Zaman ◽

Sue Ward ◽

Karen Collins ◽

Kwok-Leung Cheung ◽

Thompson Robinson ◽

...

Keyword(s):

Breast Cancer ◽

Interim Analysis ◽

Older Patients ◽

Cancer Study ◽

Age Gap ◽

Breast Cancer Study

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Assessing the Impact of a Cooperative Group Trial on Breast Cancer Care in the Medicare Population

Journal of Clinical Oncology ◽

10.1200/jco.2011.39.4890 ◽

2012 ◽

Vol 30 (14) ◽

pp. 1601-1607 ◽

Cited By ~ 85

Author(s):

Pamela R. Soulos ◽

James B. Yu ◽

Kenneth B. Roberts ◽

Ann C. Raldow ◽

Jeph Herrin ◽

...

Keyword(s):

Breast Cancer ◽

Life Expectancy ◽

Older Women ◽

Treatment Guidelines ◽

Adjuvant Radiation ◽

Adjusted Relative Risk ◽

Data Set ◽

Sample Mean ◽

Medicare Population ◽

The Impact

Purpose The Cancer and Leukemia Group B (CALGB) C9343 trial found that adjuvant radiation therapy (RT) provided minimal benefits for older women with breast cancer. Although treatment guidelines were changed to indicate that some women could forego RT, the impact of the C9343 results on clinical practice is unclear. Patients and Methods We used the Surveillance, Epidemiology, and End Results (SEER) –Medicare data set to assess the use of adjuvant RT in a sample of women ≥ 70 years old diagnosed with stage I breast cancer from 2001 to 2007 who fulfilled the C9343 inclusion criteria. We used log-binomial regression to estimate the relation between publication of C9343 and use of RT in the full sample and across strata of patient and health system characteristics. Results Of the 12,925 Medicare beneficiaries in our sample (mean age, 77.7 years), 76.5% received RT. Approximately 79% of women received RT before study publication compared with 75% after (adjusted relative risk of receiving RT postpublication v prepublication: 0.97; 95% CI, 0.95 to 0.98). Although use of RT was lower after the trial within all strata of age and life expectancy, the magnitude of this decrease did not differ significantly by strata. For instance, among patients with life expectancy less than 5 years, RT use decreased by 3.7%, from 44.4% prepublication to 40.7% postpublication. Among patients with life expectancy ≥ 10 years, RT use decreased by 3.0%, from 92.0% to 89.0%. Conclusion The C9343 trial had minimal impact on the use of RT among older women in the Medicare population, even among the oldest women and those with shorter life expectancies.

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The Age Gap study: A prospective observational cohort study to determine the relationship between age, tumour stage and biology in older women with early breast cancer

European Journal of Cancer ◽

10.1016/s0959-8049(20)30867-4 ◽

2020 ◽

Vol 138 ◽

pp. S122-S123

Author(s):

M. Lim ◽

M.H. Lee ◽

O. White ◽

L. Wyld ◽

J. Morgan ◽

...

Keyword(s):

Breast Cancer ◽

Cohort Study ◽

Older Women ◽

Early Breast Cancer ◽

Observational Cohort Study ◽

Prospective Observational Cohort Study ◽

Tumour Stage ◽

Age Gap ◽

Observational Cohort ◽

The Relationship

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Differential effect of obesity on comorbidity risk in younger and older women with early breast cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.e13601 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. e13601-e13601

Author(s):

Michael Lorentsen ◽

Allison Mary Deal ◽

Hyman B. Muss ◽

Yi Tang Chen ◽

Tucker Brenizer ◽

...

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Older Women ◽

Early Breast Cancer ◽

Differential Effect ◽

Retrospective Chart Review ◽

Future Research ◽

Obese Patients ◽

Comorbidity Burden ◽

The Impact

e13601 Background: Overall survival in women with early breast cancer (EBC) (Stage I-III) has made great strides over the past several decades, with survivors more likely to die from causes other than breast cancer. This study investigates the differential effect of obesity on pre-treatment comorbidity risk in younger versus older women with EBC. Methods: This is a retrospective chart review of women with EBC, age 21 and older, seen at a single institution. Differences in 18 common comorbidities were assessed by age ( > = 65 vs < 65) and Body Mass Index/BMI ( > = BMI 30 vs < 30), with relative risks (RR) estimated from log-binomial regression. Results: In a sample of 590 women, 24% were age 65+, 32% non-white, and 39% had obesity. Patients age 65+ were more likely to report 2+ comorbidities compared to age < 65 (RR 1.62, 69% v 43%). Obese patients (BMI > = 30) were more likely to report 2+ comorbidities compared to BMI < 30 (RR: 1.73, 66% v 38%). Women with obesity were more likely to have hyperlipidemia (RR: 1.85, 28% v 15%) as well as diabetes (RR: 2.51, 17% v 7%). The impact of BMI on comorbidity risk (2+ v < 2) differed by age group (interaction p < 0.001). In the < 65 group, obese patients were more likely to have 2+ comorbidities compared to non-obese (RR: 2.12, 62% v 29%, p < 0.0001). The difference was not as large in the 65+ group (RR: 1.28, 81% v 63%, p = 0.02). Conclusions: This study demonstrates increased comorbidity burden, including hyperlipidemia and diabetes, in women with obesity and EBC, especially those < 65. Providers should ensure that patients with obesity and EBC are appropriately screened and treated for underlying comorbidities. Future research should assess the impact of weight loss on overall survival in EBC patients.

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