Incidence and risk factors for Chyle leak after pancreatic surgery for cancer: A comprehensive systematic review

Author(s):  
Milena Muzzolini ◽  
Raphael L.C. Araujo ◽  
T. Peter Kingham ◽  
Frédérique Peschaud ◽  
François Paye ◽  
...  
Surgery ◽  
2021 ◽  
Author(s):  
Chris Varghese ◽  
Cameron Iain Wells ◽  
Shiela Lee ◽  
Samir Pathak ◽  
Ajith K. Siriwardena ◽  
...  

2016 ◽  
Vol 104 (1) ◽  
pp. 108-117 ◽  
Author(s):  
O. Strobel ◽  
S. Brangs ◽  
U. Hinz ◽  
T. Pausch ◽  
F. J. Hüttner ◽  
...  

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S74
Author(s):  
Oliver Strobel ◽  
Susanne Brangs ◽  
Ulf Hinz ◽  
Thomas Tausch ◽  
Felix J. Hüttner ◽  
...  

2021 ◽  
Vol 108 (Supplement_9) ◽  
Author(s):  
Chris Varghese ◽  
Cameron Wells ◽  
Shiela Lee ◽  
Khaled Ammar ◽  
Sanjay Pandanaboyana

Abstract Background The incidence of, and risk factors for chyle leak, as defined by the 2017 International Study Group on Pancreatic Surgery (ISGPS), remain unknown.  Methods MEDLINE, EMBASE, and Scopus were systematically searched for studies of patients undergoing pancreatectomy that reported chyle leak according to the 2017 ISGPS definition. The primary outcomes were the incidence of overall and clinically-relevant chyle leak. A random-effects pairwise meta-analysis was used to identify risk factors where possible.  Results Thirty-five studies including 7083 patients were included in the meta-analysis. The weighted incidence of overall chyle leak was 6.8% (95% CI 5.6 - 8.2) and clinically-relevant chyle leak was 5.5% (95% CI 3.8 - 7.7). Pancreaticoduodenectomy, total pancreatectomy and distal pancreatectomy were associated with a CL incidence of 7.3%, 4.3%, 5.8% respectively. Fourteen individual risk factors for chyle leak were identified from included studies. Younger age, low prognostic nutritional index, para-aortic node manipulation, lymphatic involvement, and post-pancreatectomy pancreatitis were significantly associated with chyle leak, all from individual studies. Conclusions The incidence of overall chyle leak and clinically relevant chyle leak after pancreatic surgery, as defined by the 2017 ISGPS definition is 6.8% and 5.5% respectively. Several risk factors for chyle leak were identified in the present review, however, larger high-quality studies are needed to more accurately define these risks.


Author(s):  
Faihan Alotaibi ◽  
Faisal Alnemari ◽  
Alwaleed Alsufyani ◽  
Aisha Al-sanea ◽  
Abeer Al-Nashri ◽  
...  

2021 ◽  
Author(s):  
Ekaterina Mosolova ◽  
Dmitry Sosin ◽  
Sergey Mosolov

During the COVID-19 pandemic, healthcare workers (HCWs) have been subject to increased workload while also exposed to many psychosocial stressors. In a systematic review we analyze the impact that the pandemic has had on HCWs mental state and associated risk factors. Most studies reported high levels of depression and anxiety among HCWs worldwide, however, due to a wide range of assessment tools, cut-off scores, and number of frontline participants in the studies, results were difficult to compare. Our study is based on two online surveys of 2195 HCWs from different regions of Russia during spring and autumn epidemic outbreaks revealed the rates of anxiety, stress, depression, emotional exhaustion and depersonalization and perceived stress as 32.3%, 31.1%, 45.5%, 74.2%, 37.7% ,67.8%, respectively. Moreover, 2.4% of HCWs reported suicidal thoughts. The most common risk factors include: female gender, nurse as an occupation, younger age, working for over 6 months, chronic diseases, smoking, high working demands, lack of personal protective equipment, low salary, lack of social support, isolation from families, the fear of relatives getting infected. These results demonstrate the need for urgent supportive programs for HCWs fighting COVID-19 that fall into higher risk factors groups.


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