Temperature‐responsive voltammetric sensor based on stimuli-sensitive semi-interpenetrating polymer network conductive microgels for reversible switch detection of nitrogen mustard analog chlorambucil (Leukeran™)

2021 ◽  
Vol 374 ◽  
pp. 137866
Author(s):  
Bhuvanenthiran Mutharani ◽  
Palraj Ranganathan ◽  
Shen-Ming Chen ◽  
Hsieh-Chih Tsai
Keyword(s):  
Nitrogen Mustard ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Voltammetric Sensor ◽  
Temperature Responsive ◽  
Stimuli Sensitive

Drug Release Mechanism of Fast Temperature-Responsive Soy Protein/PNIPAAm IPN Hydrogels

2013 ◽  
Vol 781-784 ◽  
pp. 803-807 ◽  
Author(s):  
Yong Liu ◽  
Shou Lian Wei ◽  
Miao Chan Liao
Keyword(s):  
Soy Protein ◽  
Polymer Network ◽  
Reaction Medium ◽  
Interpenetrating Polymer Network ◽  
Release Mechanism ◽  
Porous Structures ◽  
Temperature Responsive ◽  
Drug Release Mechanism ◽  
Potential Applications ◽  
Fast Release

Fast temperature-responsive interpenetrating polymer network hydrogels based on soy protein and poly(N-isopropylacrylamide) (PNIPAAm) were prepared using the sodium bicarbonate (NaHCO3) solutions as the reaction medium. The structure and properties were characterized using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The bovine serum albumin (BSA) release behaviors and release mechanism were also investigated. The results show that the proposed hydrogels have high porous structures and have a fast release rate. The BSA release mechanism belongs to an anomalous transport and the Fickian contribution is dominant. The proposed hydrogels may have the potential applications in the field of biomedical materials such as in the controlled release of drugs.

A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

2010 ◽  
Vol 148-149 ◽  
pp. 1449-1452 ◽  
Author(s):  
Kui Lin Deng ◽  
Yu Bo Gou ◽  
Jian Zuo ◽  
Li Rong Dong ◽  
Qian Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Network ◽  
Phosphate Buffer Solution ◽  
Interpenetrating Polymer Network ◽  
Temperature Sensitive ◽  
Buffer Solution ◽  
Hydrogel Beads ◽  
Drug Delivery Carrier ◽  
Temperature Sensitive Hydrogel ◽  
Stimuli Sensitive

A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.

scholarly journals Preparation and properties of fast temperature-responsive soy protein/PNIPAAm IPN hydrogels

2014 ◽  
Vol 79 (2) ◽  
pp. 211-224 ◽  
Author(s):  
Yong Liu ◽  
Yingde Cui ◽  
Guojie Wu ◽  
Miaochan Liao
Keyword(s):  
Soy Protein ◽  
Polymer Network ◽  
Reaction Medium ◽  
Interpenetrating Polymer Network ◽  
Fickian Diffusion ◽  
Gravimetric Analysis ◽  
Scanning Calorimetry ◽  
Temperature Responsive ◽  
Swelling Mechanism ◽  
Responsive Hydrogels

The interpenetrating polymer network of fast temperature-responsive hydrogels based on soy protein and poly(N-isopropylacrylamide) were successfully prepared using the sodium bicarbonate (NaHCO3) solutions as the reaction medium. The structure and properties of the hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry and thermal gravimetric analysis. The swelling and deswelling kinetics were also investigated in detail. The results have shown that the proposed hydrogels had high porous structure, good miscibility and thermal stability, and fast temperature responsivity. The presence of NaHCO3 had little effect on the volume phase transition temperature (VPTT) of the hydrogels, and the VPTTs were at about 32?C. Compared with the traditional hydrogels, the proposed hydrogels had much faster swelling and deswelling rate. The swelling mechanism of the hydrogels was the non-Fickian diffusion. This fast temperature-responsive hydrogels may have potential applications in the field of biomedical materials.

Investigation of temperature-responsive and thermo-physiological comfort of modified polyester fabric with Sericin/PNIPAAm/Ag NPs interpenetrating polymer network hydrogel

2020 ◽  
Vol 90 (23-24) ◽  
pp. 2622-2638
Author(s):  
Jinru Liu ◽  
Hualing He ◽  
Zhicai Yu ◽  
Abhijeet Suryawanshi ◽  
Yongquan Li ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Polymer Network ◽  
Polyester Fabric ◽  
Interpenetrating Polymer Network ◽  
Solution Temperature ◽  
Ag Nps ◽  
Stimuli Responsive Polymers ◽  
Temperature Responsive ◽  
Antibacterial Performance ◽  
Vertical Wicking

Stimuli-responsive polymers applied to traditional textiles have received widespread attention. In this work, a new type of polymer-modified polyester fabric was prepared with interpenetrating polymer network (IPN) hydrogel. The IPN hydrogel comprised of poly (N-isopropylacrylamide) (PNIPAAm), silk sericin (SS), and silver nanoparticles (Ag NPs). The presence of the IPN hydrogel on the surface of fibers can change the wettability of polyester fabric, in response to temperature. The thermal behavior of IPN hydrogel was characterized by differential scanning calorimetry (DSC) and thermogravimetric analysis (TG). DSC results indicated that the IPN hydrogel exhibits temperature-responsive behavior and the lower critical solution temperature (LCST) was around 32.9℃. The decomposition temperature of modified polyester fabric (400.5℃) was better than the original polyester fabric (335℃). TG results indicated that the polymer-modified fabric possessed higher thermal stability than the original polyester fabrics. The thermo-physiological comfort of modified polyester fabric was characterized by water contact angle and vertical wicking test. Above the LCST, the wettability of the polymer-modified polyester fabric would decrease because of the volume phase transition of IPN hydrogel. Moreover, the antibacterial activity of the modified temperature-sensitive fabric against Staphylococcus aureus and Escherichia coli was also investigated, and the antibacterial activity for both microorganisms exceeded 95%. This study provided a feasible route to fabricate the temperature-responsive textile with great antibacterial performance.

scholarly journals Porous scaffolds with the structure of an interpenetrating polymer network made by gelatin methacrylated nanoparticle-stabilized high internal phase emulsion polymerization targeted for tissue engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22544-22555
Author(s):  
Atefeh Safaei-Yaraziz ◽  
Shiva Akbari-Birgani ◽  
Nasser Nikfarjam
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cell Growth ◽  
Polymer Network ◽  
Synthetic Polymers ◽  
Tissue Scaffolds ◽  
Interpenetrating Polymer Network ◽  
Porous Scaffolds ◽  
Promising Strategy ◽  
Internal Phase

The interlacing of biopolymers and synthetic polymers is a promising strategy to fabricate hydrogel-based tissue scaffolds to biomimic a natural extracellular matrix for cell growth.

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