Stimuli-Sensitive Xanthan Derivatives/N-Isopropylacrylamide Hydrogels: Influence of Cross-Linking Agent on Interpenetrating Polymer Network Properties

AbstractA novel hydrogel wound dressing with semi-interpenetrating polymer network structure (semi-IPN) was prepared by radical polymerization of acrylic acid with potassium persulfate (K2S2O8) as initiator and N, N'-methylenebisacrylamide (MBA) as cross-linking agent in the presence of chitosan (CTS) and polyvinyl pyrrolidone (PVP). Hydrogels were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). SEM displayed semi- IPN hydrogels' creased surface with some scale-like wrinkles, thus improving the absorptive capability which has been considered as a most important characteristic of wound dressings. It was found that the content of cross-linking agent and the mass ratio of PVP and CTS had much influence on the mechanical properties of the hydrogel, varying from brittle plastics to elastomer due to the different degrees of cross linking. Since tensile strength is partly in inverse ratio to the hydrogel absorbent capability, the article offers an analysis of varying material proportion in order to obtain an optimum properties of the hydrogel wound dressing .

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A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.148-149.1449 ◽

2010 ◽

Vol 148-149 ◽

pp. 1449-1452 ◽

Cited By ~ 1

Author(s):

Kui Lin Deng ◽

Yu Bo Gou ◽

Jian Zuo ◽

Li Rong Dong ◽

Qian Li ◽

...

Keyword(s):

Drug Delivery ◽

Polymer Network ◽

Phosphate Buffer Solution ◽

Interpenetrating Polymer Network ◽

Temperature Sensitive ◽

Buffer Solution ◽

Hydrogel Beads ◽

Drug Delivery Carrier ◽

Temperature Sensitive Hydrogel ◽

Stimuli Sensitive

A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.

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Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization

Advances in Materials Science and Engineering ◽

10.1155/2013/328763 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8 ◽

Cited By ~ 42

Author(s):

Eltjani-Eltahir Hago ◽

Xinsong Li

Keyword(s):

Mechanical Properties ◽

Mtt Assay ◽

Biomedical Applications ◽

Polymer Network ◽

Physical And Mechanical Properties ◽

Morphological Characterization ◽

Interpenetrating Polymer Network ◽

Synthesis And Characterization ◽

Cross Linking ◽

New Approach

In this work, a new approach was introduced to prepare interpenetrating polymer network PVA/GE hydrogels by cross-linking of various concentration gelatin in the presence of transglutaminase enzyme by using the freezing-thawing cycles technique. The effects of freezing-thawing cycles on the properties of morphological characterization, gel fraction, swelling, mechanical, and MTT assay were investigated. The IPN PVA/GE hydrogels showed excellent physical and mechanical Properties. MTT assay data and the fibroblasts culture also showed excellent biocompatibility and good proliferation. This indicates that the IPN hydrogels are stable enough for various biomedical applications.

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