Bayesian hierarchical dose-response meta-analysis of epidemiological studies: Modeling and target population prediction methods

AbstractInverse associations between dairy consumption and CVD have been reported in several epidemiological studies. Our objective was to conduct a meta-analysis of prospective cohort studies of dairy intake and CVD. A comprehensive literature search was conducted to identify studies that reported risk estimates for total dairy intake, individual dairy products, low/full-fat dairy intake, Ca from dairy sources and CVD, CHD and stroke. Random-effects meta-analyses were used to generate summary relative risk estimates (SRRE) for high v. low intake and stratified intake dose–response analyses. Additional dose–response analyses were performed. Heterogeneity was examined in sub-group and sensitivity analyses. In total, thirty-one unique cohort studies were identified and included in the meta-analysis. Several statistically significant SRRE below 1.0 were observed, namely for total dairy intake and stroke (SRRE=0·91; 95 % CI 0·83, 0·99), cheese intake and CHD (SRRE=0·82; 95 % CI 0·72, 0·93) and stroke (SRRE=0·87; 95 % CI 0·77, 0·99), and Ca from dairy sources and stroke (SRRE=0·69; 95 % CI 0·60, 0·81). However, there was little evidence for inverse dose–response relationships between the dairy variables and CHD and stroke after adjusting for within-study covariance. The results of this meta-analysis of prospective cohort studies have shown that dairy consumption may be associated with reduced risks of CVD, although additional data are needed to more comprehensively examine potential dose–response patterns.

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Physical activity and the risk of gestational diabetes mellitus: a systematic review and dose–response meta-analysis of epidemiological studies

European Journal of Epidemiology ◽

10.1007/s10654-016-0176-0 ◽

2016 ◽

Vol 31 (10) ◽

pp. 967-997 ◽

Cited By ~ 61

Author(s):

Dagfinn Aune ◽

Abhijit Sen ◽

Tore Henriksen ◽

Ola Didrik Saugstad ◽

Serena Tonstad

Keyword(s):

Physical Activity ◽

Diabetes Mellitus ◽

Systematic Review ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Dose Response ◽

Meta Analysis ◽

Epidemiological Studies

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The level of bilirubin and the risk of ischemic stroke: a systematic review and dose-response meta-analysis of real-world studies

10.21203/rs.2.15743/v2 ◽

2020 ◽

Author(s):

Xiao Wang ◽

Yang Zhou ◽

Xiaofei Ye ◽

Fangchen Liu ◽

Xi Zhu ◽

...

Keyword(s):

Ischemic Stroke ◽

Dose Response ◽

Meta Analysis ◽

Epidemiological Studies ◽

Secondary Outcome ◽

Serum Total Bilirubin ◽

Response Relationship ◽

Dose Response Relationship ◽

Meta Analyses ◽

The Relationship

Abstract Background: Bilirubin, a marker of hepatic and hematological diseases in clinical practice, is not only a waste end-product but also an antioxidant that may protect against diseases associated with oxidative stress. Numerous epidemiological studies have shown an inverse relationship between the serum total bilirubin (TBIL) level and the risk of ischemic stroke (IS). However, markedly elevated TBIL levels may exert neurotoxic effects. Based on this, we conducted a dose-response meta-analysis to quantify the relationship between blood TBIL and IS as well as between TBIL and all types of stroke (AS) in the physiological range of bilirubin.Methods: PubMed, Embase, Web of Science, and Cochrane Central databases were searched up to March 2019. Additional studies were identified by reviewing references and contacting authors. Categorical and dose-response meta-analyses were performed to quantify the relationship between TBIL and IS. The primary outcome was ischemic stroke, and the secondary outcome was all types of stroke.Results: Nine observational studies (seven publications) involving 110,032 participants and 3710 stroke cases were included for analysis. The average OR of IS for every 1 µmol/L increment in TBIL level was 0.978 (95% CI: 0.957–0.999). The summary OR of AS for every 1 µmol/L increment in TBIL level was 0.974 (95% CI: 0.956–0.992). Subgroup analysis based on gender showed a negative dose-response relationship between the circulating TBIL level and IS or AS in males, but not in females.Conclusions: The present study found a negative dose-response relationship between the circulating TBIL level and the risk of IS or AS within physiologic range of serum TBIL in males. Moderately elevated blood TBIL levels might be associated with a diminished prevalence of IS. Every 1 µmol/L increment in serum TBIL level was associated with a 2.2% decrease in the risk of IS and a 2.6% decrease in the risk of AS. However, due to the limitations in the number of included studies and their quality, large-scaled prospective cohort studies are needed to confirm the conclusion of the current analysis.Trial registration: This study was registered at PROSPERO (https://www.crd. york.ac.uk/PROSPERO/[CRD42017075988]).

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Nut Intake and Risk of Cancer and its Mortality: a Study Protocol for a Systematic Review and Dose-Response Meta-analysis of Observational Studies

Critical Comments in Biomedicine ◽

10.18502/ccb.v1i2.4282 ◽

2020 ◽

Author(s):

Sina Naghshi ◽

Omid Sadeghi ◽

Mohammad Naemi ◽

Mehrasa Moezrad

Keyword(s):

Systematic Review ◽

Cancer Risk ◽

Study Protocol ◽

Dose Response ◽

Observational Studies ◽

Meta Analysis ◽

Target Population ◽

Random Effects Models ◽

Risk Of Cancer ◽

Nut Intake

Background: This study protocol outlines the planned, systematic review and dose-response meta-analysis of nuts intake with cancer risk and its mortality. Methods: This meta-analysis will be done based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P). A systematic literature search will be conducted using online databases, including PubMed/Medline, ISI Web of Science, and Scopus with no limitation in language or time of publication to identify observational studies investigating the association of nuts intake with cancer risk and its mortality. The target population will be adults (≥18 years of age). Random-effects models will be used to calculate pooled effect sizes (ESs) for the risk of cancer and its mortality based on the comparison between the highest and lowest categories of nut intake and to incorporate variation between studies. Linear and non-linear dose-response analyses will be done to evaluate the dose-response associations between nut intake and risk of cancer and its mortality. The Newcastle-Ottawa Scale (NOS) will be used to assess the risk of bias or quality of included studies. Conclusion: The findings of this systematic review and dose-response meta-analysis will summarize all available evidence on the association between nut intake and risk of cancer and its mortality.

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Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies

Nutrients ◽

10.3390/nu9050500 ◽

2017 ◽

Vol 9 (5) ◽

pp. 500 ◽

Cited By ~ 14

Author(s):

Lirong Zeng ◽

Sheng Hu ◽

Pengfei Chen ◽

Wenbin Wei ◽

Yuanzhong Tan

Keyword(s):

Systematic Review ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Dose Response ◽

Meta Analysis ◽

Epidemiological Studies ◽

Macronutrient Intake

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Breastfeeding and thyroid cancer risk in women: A dose-response meta-analysis of epidemiological studies

Clinical Nutrition ◽

10.1016/j.clnu.2015.12.005 ◽

2016 ◽

Vol 35 (5) ◽

pp. 1039-1046 ◽

Cited By ~ 5

Author(s):

Xingyang Yi ◽

Jingjing Zhu ◽

Xiao Zhu ◽

Guang Jian Liu ◽

Lang Wu

Keyword(s):

Thyroid Cancer ◽

Cancer Risk ◽

Dose Response ◽

Meta Analysis ◽

Epidemiological Studies ◽

Thyroid Cancer Risk

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Association between maternal vitamin D levels and risk of adverse pregnancy outcomes: a systematic review and dose–response meta-analysis

Food & Function ◽

10.1039/d1fo03033g ◽

2021 ◽

Author(s):

Rui Zhao ◽

Leilei Zhou ◽

Shanshan Wang ◽

Guoping Xiong ◽

Liping Hao

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Dose Response ◽

Pregnancy Outcomes ◽

Meta Analysis ◽

Epidemiological Studies ◽

Adverse Pregnancy Outcomes ◽

Maternal Vitamin ◽

Vitamin D Levels ◽

Adverse Pregnancy

Epidemiological studies have investigated the associations between vitamin D and the risk of adverse pregnancy outcomes; however, the results are conflicting and dose–response relationships remain to be confirmed.

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