Assessment of genotoxicity and oxidative stress in pregnant women contaminated to organochlorine pesticides and its correlation with pregnancy outcome

2022 ◽  
Vol 204 ◽  
pp. 112010
Author(s):  
Naina Dwivedi ◽  
Abbas Ali Mahdi ◽  
Sujata Deo ◽  
Mohammad Kaleem Ahmad ◽  
Durgesh Kumar
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Organochlorine Pesticides ◽  
And Oxidative Stress

Comparison of Salivary Antioxidants and Oxidative Stress Status in Gestational Diabetes Mellitus and Healthy Pregnant Women

2020 ◽  
Vol 20 ◽  
Author(s):  
Fatemeh Ahmadi-Motamayel ◽  
Shima Fathi ◽  
Mohammad Taghi Goodarzi ◽  
Shiva Borzouei ◽  
Jalal Poorolajal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Oxidative Stress Markers ◽  
Blood Samples ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Total Oxidative Stress ◽  
And Oxidative Stress

Background: One of the most common complications of pregnant women is gestational diabetes mellitus (GDM). Oxidative stress can play an important role in GDM. Objective: The aim of this study was to evaluate salivary antioxidants and oxidative stress markers in GDM. Method: Twenty pregnant women with GDM and 20 healthy pregnant women with normal blood glucose test participated in this study. Five mL of unstimulated saliva samples were collected. Spectrophotometric assay was carried out for sialochemical analysis. Stata software was used for data analysis. Results: The GDM group exhibited no significant difference in salivary total antioxidant capacity and malondialdehyde compared to the healthy control group. All of antioxidants markers, the uric acid, total antioxidant, peroxidase and catalase, decreased in GDM group that the difference of peroxidase and catalase was statistically significant. All of oxidative stress markers, the salivary malondyaldehid, total oxidative stress and total thiol, increased in GDM group. GDM group exhibited significantly higher salivary total oxidative stress levels. Conclusion: Catalase level was significantly lower and total oxidative stress was significantly higher. These two markers might have significant importance and might exhibit early changes compared to other factors in GDM. . Some of salivary antioxidants might have diagnostic, prognostic or therapeutic implications in GDM. Other studies with large sample size on salivary and blood samples need to be done to confirm this properties and salivary samples using instead of blood samples in GDM biomarkers changes.

scholarly journals Moderate NaFeEDTA supplementation improves both hematologic status and oxidative stress in anemic pregnant women

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Xiu xia Han ◽  
Yong Y Sun ◽  
Ai G Ma ◽  
Dian C Jiang ◽  
Yong Li
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
And Oxidative Stress

scholarly journals An exploratory analysis of urinary organophosphate ester metabolites and oxidative stress among pregnant women in Puerto Rico

2020 ◽  
Vol 703 ◽  
pp. 134798 ◽  
Author(s):  
Mary E. Ingle ◽  
Deborah Watkins ◽  
Zaira Rosario ◽  
Carmen M. VélezVega ◽  
Antonia M. Calafat ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Puerto Rico ◽  
Pregnant Women ◽  
Exploratory Analysis ◽  
And Oxidative Stress

scholarly journals Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine, and Oxidative Stress Parameters in Pregnant Women—The Pilot Study

2019 ◽  
Vol 16 (9) ◽  
pp. 1656 ◽  
Author(s):  
Lubica Argalasova ◽  
Ingrid Zitnanova ◽  
Diana Vondrova ◽  
Monika Dvorakova ◽  
Lucia Laubertova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Antioxidant Capacity ◽  
Pregnant Women ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Passive Smoking ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

Background: Exposure to ETS (environmental tobacco smoke) is one of the most toxic environmental exposures. Objective: To investigate the association of ETS with physiological, biochemical, and psychological indicators, as well as with urine antioxidant capacity (AC) and oxidative damage to lipids in a pilot sample of healthy pregnant women. Methods: Exposure to ETS was investigated via a validated questionnaire, and urine cotinine and the marker of oxidative damage to lipids via 8-isoprostane concentrations using an ELISA kit. Urine AC was determined by the spectrophotometric Trolox-equivalent antioxidant capacity (TEAC) method. From a sample of pregnant women (n = 319, average age 30.84 ± 5.09 years) in 80, the levels of cotinine and oxidative stress markers were analyzed. Results: Among the 80 pregnant women, 5% (7.4% confirmed by cotinine) reported being current smokers and 25% reported passive smoking in the household (18.8% confirmed by cotinine). The Kappa was 0.78 for smokers and 0.22 for ETS-exposed nonsmokers. Pregnant women in the ETS-exposed group had significantly reduced AC compared to both the nonsmoker (ETS−) and the smoker groups (p < 0.05). Nonsmokers had significantly lower levels of 8-isoprostane than smokers (p < 0.01) and ETS-exposed nonsmokers (p < 0.05). Correlations between urine levels of cotinine and AC were positive in ETS-exposed nonsmokers. Conclusion: A harmful association of active and passive smoking and oxidative stress parameters among pregnant women has been indicated.

Antioxidants and oxidative stress in normal and preeclamptic Portuguese pregnant women

2000 ◽  
Vol 151 (1) ◽  
pp. 308
Author(s):  
L. Belo ◽  
I. Rebelo ◽  
A. Santos-Silva ◽  
E.M.B. Castro ◽  
L. Pereira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
And Oxidative Stress

scholarly journals EXPRESSION OF SERUM CYTOKINE( IL-17) AND OXIDATIVE STRESS MARKER (GSH) IN IRAQI PREGNANT WOMEN WITH PRE-ECLAMPSIA.

2016 ◽  
Vol 4 (10) ◽  
pp. 2132-2140
Author(s):  
IsraaA.AbdulKareem MBChB,MS.c,FICMS ◽  
◽  
EnasAdnanAAl-Kazaaly MBChB,CABOG,FIBMS ◽  
MohammedI.Hamzah Ph.D ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
Oxidative Stress Marker ◽  
Serum Cytokine ◽  
Stress Marker ◽  
And Oxidative Stress

scholarly journals Gestational Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy

Obesity Facts ◽  
2021 ◽  
pp. 1-9
Author(s):  
Juan Mario Solis Paredes ◽  
Otilia Perichart Perera ◽  
Araceli Montoya Estrada ◽  
Enrique Reyes Muñoz ◽  
Salvador Espino y Sosa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Weight Gain ◽  
Pregnant Women ◽  
Gestational Weight Gain ◽  
Antioxidant Systems ◽  
Linear Regression Models ◽  
Future Health ◽  
Gestational Weight ◽  
Metabolic Marker ◽  
And Oxidative Stress

<b><i>Introduction and Objective:</i></b> The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. This study was aimed to investigate the association between adipokines and oxidative stress markers in pregnant women and the influence of the GWG on this association. <b><i>Methods:</i></b> Maternal blood samples were obtained in the third trimester of pregnancy (<i>n</i> = 74) and serum adipokines (adiponectin, leptin, and resistin), oxidative damage markers: 8-oxo-2′-deoxyguanosine (8-oxodG), lipohydroperoxides (LOOH), malondialdehyde (MDA), and carbonylated proteins (CP), and glucose a metabolic marker were measured. <b><i>Results:</i></b> Women with EGWG had low adiponectin levels than women with adequate weight gain (AWG) or insufficient weight gain (IWG). Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (<i>B</i> = 1.09, 95% CI: 164–222, <i>p</i> = 0.027) and IWG (<i>B</i> = 0.860, 95% CI: 0.199–1.52, <i>p</i> = 0.013) but not in women with EGWG. In women with EGWG, leptin was positively associated with LOOH (<i>p</i> = 0.018), MDA (<i>p</i> = 0.005), and CP (<i>p</i> = 0.010) oxidative markers. <b><i>Conclusion:</i></b> Our findings suggest that concurrent mechanisms regulate adipokine production and oxidative stress in pregnant women and that this regulation is influenced by GWG, probably due to an excessive AT accumulation.

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