Association between some endocrine-disrupting chemicals and childhood obesity in biological samples of young girls: A cross-sectional study

AbstractBackground:The cause of precocious puberty may be associated with genetics and other conditions such as central nervous system (CNS) insults, or the exposure to endocrine disrupting chemicals (EDCs). Phthalates is known to be one of the EDCs and have estrogenic and antiandrogenic activities, and may be associated with advanced puberty. The objective of the study was to determine the association between urinary phthalate metabolites and advanced puberty.Methods:A cross-sectional study was conducted in patients with precocious puberty (breast onset <8 years, n=42) and early puberty (breast onset 8–9 years, n=17), compared to age-matched controls (n=77). Anthropometric measurements, estradiol, basal and gonadotropin releasing hormone (GnRH)-stimulated follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels, uterine sizes, ovarian diameters and bone ages (BA) were obtained. Urine samples were collected and mono-methyl phthalate (MMP) and mono-ethyl phthalate (MEP) were analyzed by high performance liquid chromatography (HPLC) and adjusted with urine creatinine.Results:The median adjusted-MEP concentration in girls with precocious puberty, was greater than in normal girls (6105.09 vs. 4633.98 μg/g Cr: p<0.05), and had the same trend among early puberty and normal puberty (5141.41 vs. 4633.98 μg/g Cr: p=0.4), but was not statistically significant.Conclusions:Precocious puberty girls had an association with increased MEP concentration. This is the first report of the association between urinary phthalate levels and precocious puberty in Thai girls.

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Maternal occupational exposure to endocrine-disrupting chemicals during pregnancy and semen parameters in adulthood: results of a nationwide cross-sectional study among Swiss conscripts

Yearbook of Paediatric Endocrinology ◽

10.1530/ey.18.15.10 ◽

2021 ◽

Author(s):

M Istvan ◽

R Rahban ◽

B Dananche ◽

A Senn ◽

E Stettler ◽

...

Keyword(s):

Occupational Exposure ◽

Endocrine Disrupting Chemicals ◽

Cross Sectional Study ◽

Semen Parameters ◽

Sectional Study ◽

Cross Sectional ◽

Endocrine Disrupting

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Prevalence of childhood obesity in a northeastern Ontario city--a cross-sectional study

PsycEXTRA Dataset ◽

10.1037/e508992013-194 ◽

2005 ◽

Author(s):

Foyez Haque ◽

Alberto de la Rocha ◽

Betty Ann Horbul ◽

Patricia Desroches ◽

Craig Orrell

Keyword(s):

Childhood Obesity ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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A cross sectional study of lifestyle factors associated with childhood obesity among school children

MedPulse International Journal of Medicine ◽

10.26611/10111231 ◽

2019 ◽

Vol 12 (3) ◽

pp. 31-36

Author(s):

Sachin Prakashrao Rathod ◽

◽

Rujuta S Hadaye ◽

Keyword(s):

Childhood Obesity ◽

School Children ◽

Cross Sectional Study ◽

Lifestyle Factors ◽

Sectional Study ◽

Cross Sectional ◽

Factors Associated

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Urinary Paraben Concentration and Its Association with Serum Triglyceride Concentration in 2013-2014 NHANES Participants: A Cross-Sectional Study

Journal of Environmental and Public Health ◽

10.1155/2020/8196014 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Rebecca Pazos ◽

Cristina Palacios ◽

Adriana Campa

Keyword(s):

Geometric Mean ◽

Serum Triglyceride ◽

Health Impact ◽

Cross Sectional Study ◽

Urinary Concentration ◽

Sectional Study ◽

Cross Sectional ◽

Endocrine Disrupting ◽

Serum Triglyceride Concentration ◽

Hispanic White

Background. Alkyl esters of para-hydroxybenzoic acid, colloquially known as parabens, are types of preservatives found in multiple foodstuffs, pharmaceuticals, and personal care products to which Americans are exposed daily. It is unclear if parabens exhibit endocrine-disrupting properties. Parabens may interact with triglycerides in adipose tissue and impact lipid metabolism. Objective. To evaluate the association between urinary paraben concentrations and serum triglyceride concentrations. Design. A cross-sectional study. Setting. The Mobile Examination Centers affiliated with 2013-2014 NHANES. Participant(s). 827 adults (20 years or older) affiliated with the 2013-2014 NHANES. Intervention(s). None. Main Outcome Measure(s). Triglyceride levels were associated with urinary paraben concentrations (methyl, ethyl, and propyl) using a hierarchical multiple regression, adjusting for ethnicity/race, gender, BMI, and age. Unadjusted results are also reported. Results. The geometric mean of the urinary concentration of methylparaben, ethylparaben, and propylparaben was 57.100, 2.537, and 6.537 ng/ml, respectively. Triglyceride concentrations were inversely associated with methylparaben (β = −0.092, P=0.07), ethylparaben (β = −0.066, P=0.045), and propylparaben (β = −0.076, P=0.025). Being female, non-Hispanic White, and non-Hispanic Black were associated with decreasing triglyceride levels in the presence of methylparaben, ethylparaben, and propylparaben, and age, BMI, and being male were associated with increasing circulating triglycerides. Conclusion. Despite the potential detrimental effects of parabens on triglycerides, our results suggest that urinary excretions of methylparaben, ethylparaben, and propylparaben are associated with lower concentrations of circulating triglycerides in certain populations. Further research is needed to confirm the mechanisms and health impact of this relationship.

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