scholarly journals Urinary Paraben Concentration and Its Association with Serum Triglyceride Concentration in 2013-2014 NHANES Participants: A Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Rebecca Pazos ◽  
Cristina Palacios ◽  
Adriana Campa
Keyword(s):  
Geometric Mean ◽  
Serum Triglyceride ◽  
Health Impact ◽  
Cross Sectional Study ◽  
Urinary Concentration ◽  
Sectional Study ◽  
Cross Sectional ◽  
Endocrine Disrupting ◽  
Serum Triglyceride Concentration ◽  
Hispanic White

Background. Alkyl esters of para-hydroxybenzoic acid, colloquially known as parabens, are types of preservatives found in multiple foodstuffs, pharmaceuticals, and personal care products to which Americans are exposed daily. It is unclear if parabens exhibit endocrine-disrupting properties. Parabens may interact with triglycerides in adipose tissue and impact lipid metabolism. Objective. To evaluate the association between urinary paraben concentrations and serum triglyceride concentrations. Design. A cross-sectional study. Setting. The Mobile Examination Centers affiliated with 2013-2014 NHANES. Participant(s). 827 adults (20 years or older) affiliated with the 2013-2014 NHANES. Intervention(s). None. Main Outcome Measure(s). Triglyceride levels were associated with urinary paraben concentrations (methyl, ethyl, and propyl) using a hierarchical multiple regression, adjusting for ethnicity/race, gender, BMI, and age. Unadjusted results are also reported. Results. The geometric mean of the urinary concentration of methylparaben, ethylparaben, and propylparaben was 57.100, 2.537, and 6.537 ng/ml, respectively. Triglyceride concentrations were inversely associated with methylparaben (β = −0.092, P=0.07), ethylparaben (β = −0.066, P=0.045), and propylparaben (β = −0.076, P=0.025). Being female, non-Hispanic White, and non-Hispanic Black were associated with decreasing triglyceride levels in the presence of methylparaben, ethylparaben, and propylparaben, and age, BMI, and being male were associated with increasing circulating triglycerides. Conclusion. Despite the potential detrimental effects of parabens on triglycerides, our results suggest that urinary excretions of methylparaben, ethylparaben, and propylparaben are associated with lower concentrations of circulating triglycerides in certain populations. Further research is needed to confirm the mechanisms and health impact of this relationship.

scholarly journals Urinary Paraben Concentrations and Its Association with Serum Triglyceride Concentrations in 2013–2014 NHANES Participants (P08-120-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Rebecca Pazos ◽  
Cristina Palacios ◽  
Adriana Campa
Keyword(s):  
Waist Circumference ◽  
Serum Triglyceride ◽  
Health Impact ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Funding Sources ◽  
Endocrine Disrupting ◽  
Race Ethnicity ◽  
Florida International University ◽  
Internal Funding

Abstract Objectives Alkyl esters of para-hydroxybenzoic acid, colloquially known as parabens, are types of preservatives found in multiple foodstuffs, pharmaceuticals and personal care products to which Americans are exposed daily. It is unclear if parabens exhibit carcinogenic or endocrine-disrupting properties. Methylparaben and propylparaben, two of the parabens most commonly found in foods, may interact with triglycerides in adipose tissue and impact lipid metabolism. Due to the potential for adverse impact, it is imperative to study how parabens interact with lipids in humans. Our objective was to evaluate the association between urinary parabens and serum triglyceride concentrations. Methods This cross-sectional study used data from adults 20 years and older from the 2013–2014 NHANES. Triglyceride levels were associated with urinary paraben concentrations (methyl and propyl) using a Hierarchical Multiple Regression, adjusting for ethnicity/race, gender, waist circumference, BMI and age. Results A total of 794 participants were included in the analyses; their mean age was 49.7 years, 52.4% were female, 43.07% were white, and 20.2% were black. Triglycerides were inversely associated with methylparaben (CI 95% −.054, −.004, β = -0.82, P = 0.022) and propylparaben (CI 95% −.04, −.003, β = -0.81, P = 0.026). When adjusting for age, gender, race/ethnicity, BMI and waist circumference, the model remained significant for methylparaben (P < 0.05, adjusted R2 = .140), and propylparaben (P < 0.05, adjusted R2 = .140). Conclusions Despite the potential detrimental effects of parabens on triglycerides, our results suggest that urinary excretion of methylparaben and propylparaben are associated with lower circulating triglycerides. Further research is needed to confirm the mechanisms and health impact of this relationship. Funding Sources Florida International University Internal Funding.

Associated Factors and Health Impact of Sarcopenia in Older Chinese Men and Women: A Cross-Sectional Study

Gerontology ◽  
2007 ◽  
Vol 53 (6) ◽  
pp. 404-410 ◽  
Author(s):  
Jenny S.W. Lee ◽  
Tung-Wai Auyeung ◽  
Timothy Kwok ◽  
Edith M.C. Lau ◽  
Ping-Chung Leung ◽  
...  
Keyword(s):  
Associated Factors ◽  
Health Impact ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Men And Women ◽  
Chinese Men ◽  
Older Chinese

Preheparin serum lipoprotein lipase mass interacts with gender, gene polymorphism and, positively, with smoking

2009 ◽  
Vol 47 (2) ◽  
Author(s):  
Altan Onat ◽  
Gülay Hergenç ◽  
Mehmet Agırbaşlı ◽  
Zekeriya Kaya ◽  
Günay Can ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
Geometric Mean ◽  
Population Sample ◽  
Cross Sectional Study ◽  
Serum Lipoprotein ◽  
Adult Treatment Panel ◽  
Sectional Study ◽  
Positive Interaction ◽  
Cross Sectional ◽  
Lpl Mass

Abstract: Correlates of preheparin serum lipoprotein lipase (LPL) mass and its associations with the likelihood of metabolic syndrome (MS) and coronary heart disease (CHD) were investigated.: A cross-sectional study was carried out in a population sample (n=352, median age 55). MS was defined according to modified Adult Treatment Panel III criteria.: Age-adjusted geometric mean preheparin LPL concentrations were 58.6±1.04 ng/mL in men and 66.9±1.03 ng/mL in women (p<0.004). A positive interaction with both the:Clin Chem Lab Med 2009;47:208–15.

scholarly journals Risk factors associated with oral manifestations and oral health impact of gastro-oesophageal reflux disease: a multicentre, cross-sectional study in Pakistan

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e021458 ◽  
Author(s):  
Ibrahim Warsi ◽  
Javeria Ahmed ◽  
Anjum Younus ◽  
Abdur Rasheed ◽  
Tayyab Saeed Akhtar ◽  
...  
Keyword(s):  
Oral Health ◽  
Reflux Disease ◽  
Health Impact ◽  
Cross Sectional Study ◽  
Oral Manifestations ◽  
Sectional Study ◽  
Hard Tissue ◽  
Cross Sectional ◽  
Tissue Changes ◽  
Group A

ObjectiveGastro-oesophageal reflux disease (GORD) is a relatively common disorder and manifests with extraoesophageal symptoms, such as dental erosions (DE), cough, laryngitis, asthma, and oral soft- and hard-tissue pathologies. This study aimed (1) to identify oral soft and hard-tissue changes in patients with GORD and (2) to evaluate these oral changes as indices for assessing GORD and its severity.SettingThis cross-sectional study was conducted at four major tertiary care government hospitals, in two metropolitan cities of Pakistan.ParticipantsIn total, 187 of 700 patients who underwent oesophago–gastro–duodenoscopy and having GORD were included in the study. Patients with GORD were divided according to the presence of DE into group A (with DE, chronic/severe GORD) and group B (without DE, mild GORD). Patients who were unconscious and had extremely limited mouth opening were excluded.Primary and secondary outcome measuresAbnormal conditions and lesions of the oral mucosa were recorded. The impact of oral hard and soft-tissue changes on the oral health-related quality of life was assessed using the Pakistani (Urdu) version of the validated Oral Health Impact Profile-14 (OHIP-14) instrument.ResultsOral submucous fibrosis (66.3%), ulceration (59.4%) and xerostomia (47.6%) were significantly more common in group A (p<0.05). The prevalence of GORD was 26.7%, within which the prevalence of DE was 35.3%. Unhealthy dietary pattern, nausea/vomiting, oesophagitis, xerostomia, ulceration, gingivitis and angular cheilitis showed a statistically significant association with chronic GORD and DE. All subscales of OHIP-14 were positively correlated (p<0.05) in patients with GORD and DE, with notable impact on psychological discomfort (rs=0.30), physical disability (rs=0.29), psychological disability (rs=0.27) and functional limitation (rs=0.20).ConclusionPatients with GORD and DE presented with more severe oral manifestations than did those with GORD and no DE. We recommend timely dental check-ups to assess the severity of both systemic and oral disease.

scholarly journals Factors associated with elevated alanine aminotransferase in employees of a German chemical company: results of a large cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Matthias Claus ◽  
Christoph Antoni ◽  
Bernd Hofmann
Keyword(s):  
Logistic Regression ◽  
Quantile Regression ◽  
Alanine Aminotransferase ◽  
Geometric Mean ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Multivariable Logistic Regression Model ◽  
Related Factors ◽  
Cross Sectional ◽  
Chemical Company

Abstract Background We aimed to determine the prevalence of elevated alanine aminotransferase (eALT) in employees of a German chemical company, and analyze its association with sociodemographic, work- and lifestyle-related factors. Methods The cross-sectional study is based on data surveyed from occupational health check-ups between 2013 and 2018 at the site clinic of a chemical company based in Ludwigshafen, Germany. We used logistic regression analyses to assess the association between sociodemographic, work- and lifestyle-related characteristics and eALT. Quantile regression technique was applied to investigate if associations vary across different quantiles of the ALT distribution. Results Participants (n = 15,348) were predominantly male (78.3%) with a mean age of 42.2 years (SD 10.7). The prevalence of eALT was 18.5% (21.6% in men/7.2% in women) with a geometric mean of 28.9 U/L (32.8 U/L in men/18.5 U/L in women). In the multivariable logistic regression model, odds of eALT were significantly higher for males (OR 2.61; 95%-CI 2.24–3.05), manual workers (OR 1.23; 95%-CI 1.06–1.43), overweight (OR 2.66; 95%-CI 2.36–3.00) or obese respondents (e.g. OR 7.88; 95%-CI 5.75–10.80 for obesity class III), employees who consume any number of alcoholic drinks/week (e.g. OR 1.32; 95%-CI 1.16–1.49 for ≥ 3 drinks per week) and diabetics (OR 1.47; 95%-CI 1.22–1.78). Additionally, season of participation was significantly associated with eALT, with odds being higher for participation in spring, fall or winter, as compared to summer. A significant interaction between age and gender (pInteraction < 0.001) was found, showing approximately a u-shaped age/ALT relationship in women and an inversely u-shaped relationship in men. Quantile regression showed an increasing positive effect of male gender, overweight/obesity, and for diabetics on ALT level when moving from the lowest (q0.1) to the highest (q0.9) considered quantile. Additionally, from the lowest to the highest quantile an increasing negative effect on ALT for older age was observed. Conclusions Prevalence of eALT in our sample of employees can be considered as high, with almost one in five participants affected. Identification of risk groups allows the implementation of targeted preventive measures in order to avoid transition to severe morbidity.

scholarly journals Cross-sectional study of changes in physical activity behavior during the COVID-19 pandemic among US adults

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Kathleen B. Watson ◽  
Geoffrey P. Whitfield ◽  
George Huntzicker ◽  
John D. Omura ◽  
Emily Ussery ◽  
...  
Keyword(s):  
Physical Activity ◽  
Health Disparities ◽  
Physical Activity Behavior ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Black Adults ◽  
Cross Sectional ◽  
Activity Behavior ◽  
White Adults ◽  
Hispanic White

Abstract Background Physical activity (PA) provides numerous health benefits relevant to the COVID-19 pandemic. However, concerns exist that PA levels may have decreased during the pandemic thus exacerbating health disparities. This study aims to determine changes in and locations for PA and reasons for decreased PA during the pandemic. Methods Reported percentage of changes in and locations for PA and reasons for decreased PA were examined in 3829 US adults who completed the 2020 SummerStyles survey. Results Overall, 30% reported less PA, and 50% reported no change or no activity during the pandemic; percentages varied across subgroups. Adults who were non-Hispanic Black (Black) or Hispanic (vs. non-Hispanic White, (White)) reported less PA. Fewer Black adults (vs. White) reported doing most PA in their neighborhood. Concern about exposure to the virus (39%) was the most common reason adults were less active. Conclusions In June 2020, nearly one-third of US adults reported decreased PA; 20% reported increased PA. Decreased activity was higher among Black and Hispanic compared to White adults; these two groups have experienced disproportionate COVID-19 impacts. Continued efforts are needed to ensure everyone has access to supports that allow them to participate in PA while still following guidance to prevent COVID-19 transmission.

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