Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat

2008 ◽  
Vol 59 (5) ◽  
pp. 273-279 ◽  
Author(s):  
Mami Kouchi ◽  
Kazuo Okimoto ◽  
Izumi Matsumoto ◽  
Yoshiko Michimae ◽  
Toru Yamada ◽  
...  
Keyword(s):  
Tumor Biology ◽  
2009 ◽  
Vol 30 (5-6) ◽  
pp. 249-256 ◽  
Author(s):  
Izumi Matsumoto ◽  
Mami Kouchi ◽  
Kazuo Okimoto ◽  
Kazuyasu Kijima ◽  
Tadayoshi Ueda ◽  
...  

2009 ◽  
Vol 61 (3) ◽  
pp. 283
Author(s):  
Mami Kouchi ◽  
Kazuo Okimoto ◽  
Izumi Matsumoto ◽  
Yoshiko Michimae ◽  
Toru Yamada ◽  
...  

Oncogene ◽  
2005 ◽  
Vol 25 (20) ◽  
pp. 2885-2889 ◽  
Author(s):  
Y Togashi ◽  
T Kobayashi ◽  
S Momose ◽  
M Ueda ◽  
K Okimoto ◽  
...  

1988 ◽  
Vol 211 (1) ◽  
pp. 72-77 ◽  
Author(s):  
Robert K. Hamatake ◽  
Kenneth J. Buckley ◽  
Masaki Hayashi

1997 ◽  
pp. 233-237
Author(s):  
Joanna Sypecka ◽  
Krystyna Domañska-Janik
Keyword(s):  

Development ◽  
1993 ◽  
Vol 118 (4) ◽  
pp. 1041-1048 ◽  
Author(s):  
A.J. Harwood ◽  
A. Early ◽  
J.G. Williams

The ecmA and ecmB genes of Dictyostelium encode related extracellular matrix proteins and both are induced by DIF, the stalk cell-specific morphogen. The ecmA gene is expressed throughout the prestalk region of the migrating slug but only later, at culmination, do the prestalk cells express the ecmB gene. Expression of the ecmB gene is induced at the entrance to the stalk tube and we have identified two, apparently redundant, promoter elements that control this process. They act as repressors, preventing transcription in the tip of the migrating slug and the apical papilla of the culminant. They have a semi-palindromic consensus sequence TTGnCAA, where n is in one case 2 and in the other 4 bp. Either element alone is able to repress ecmB promoter activity in prestalk cells. Introduction of a single repressor element into the promoter of the ecmA gene changes its expression pattern to resemble that of the ecmB gene. Mutant elements, where n is altered, cause repression during the slug stage but allow premature ecmB expression during culmination; suggesting that the effective strength of the inductive signal may increase during culmination. Inhibition of cAMP-dependent protein kinase (PKA) in prestalk cells blocks both stalk cell maturation and ecmB gene expression. We show that the block to gene expression correlates precisely with the presence of a functional repressor element and this is consistent with the notion that expression of the ecmB gene is controlled by a PKA-dependent release from transcriptional repression.


1987 ◽  
Vol 65 (2) ◽  
pp. 215-221 ◽  
Author(s):  
K. N. Chandra Sekhar ◽  
V. K. Sawhney

A comparative study on the ontogeny of the fusion of floral organs of the normal (cv. Pearson) and a single-gene mutant, "solanifolia" (sf/sf), of tomato (Lycopersicon esculentum Mill.) was conducted. In the normal, floral organs were laterally fused, although the degree and the region of fusion varied in each organ type. In the mutant, the various organs either did not fuse or, if they did, were individually recognizable. The sepals and petals of mutant flowers, unlike those of the normal, did not form a calyx cup and a corolla tube, respectively, and this was related to the limited lateral growth of mutant primordia and the absence of growth in the interprimordial region. Also, petal primordia of the mutant were narrower in width at inception. The stamens of normal flowers were fused by interweaving rows of lateral and adaxial hairs on the anthers. The mutant stamens produced lateral and adaxial hairs, yet they were free. The nonfusion of mutant stamens was related to the smaller primordium widths, greater distance between the primordia, and the larger apex diameter at the time of stamen initiation. The gynoecium of normal flowers consisted of a single ovary, style, and stigma formed by the fusion of carpel primordia. In the mutant, the gynoecium consisted of several carpels, laterally adhered to each other, and each had a recognizable style and stigma. The lack of fusion of mutant carpels was attributed to the larger apex diameter of the mutant during carpel initiation.


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