Cerebrovascular lesion aggravates instrumental activity of daily life in Alzheimer's disease patients

2013 ◽  
Vol 4 ◽  
pp. S212
Author(s):  
Y. Takeya ◽  
Y. Maekawa ◽  
R. Oguro ◽  
N. Sato ◽  
H. Rakugi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Daily Life ◽  
Instrumental Activity ◽  
Activity Of Daily Life ◽  
Cerebrovascular Lesion

scholarly journals Awareness for People With Alzheimer’s Disease: Profiles and Weekly Trajectories

2022 ◽  
Vol 13 ◽  
Author(s):  
Amandine Mayelle ◽  
Capucine Hazebrouck ◽  
Mohamad El Haj ◽  
Daniel C. Mograbi ◽  
Pascal Antoine
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Interindividual Variability ◽  
Daily Life ◽  
Self Awareness ◽  
Time Intervals ◽  
Disease Awareness ◽  
Semistructured Interviews ◽  
Short Time ◽  
Underlying Processes

Objective: To understand awareness and fluctuations of awareness in Alzheimer’s disease (AD), it is fruitful to consider the objects of awareness, e.g., cognitive functioning or recognition of the disease, as well as the mechanisms and modes of expression underlying awareness. With a holistic and discourse-centered approach, we aimed to identify different awareness profiles and test whether these profiles were stable or whether transitions from one profile to another occurred over short time intervals.Methods: Twenty-eight residents of nursing homes with a diagnosis of AD participated in four semistructured interviews at biweekly intervals. These interviews were cluster analyzed to determine profiles of awareness. A Markov chain was applied to model their fluctuation.Results: Five awareness profiles were observed that differed in terms of objects and underlying processes. Awareness proved to be quite stable for four of the five profiles. Interindividual variability in awareness was also observed through numerous different trajectories that were identified.Discussion: Self-awareness and disease awareness are characterized by profiles that vary subtly between individuals. Fluctuations in awareness underscore the need to employ assessment intervals that closely reflect daily life in institutions.

Neuromotor Changes in Alzheimer's Disease: Implications for Patient Care

1997 ◽  
Vol 10 (3) ◽  
pp. 93-98 ◽  
Author(s):  
Liduïn E.M. Souren ◽  
Emile H. Franssen ◽  
Barry Reisberg
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Patient Care ◽  
Care Management ◽  
Daily Life ◽  
Management Strategies ◽  
Behavioral Disturbances ◽  
Severe Stage ◽  
Neuromotor Function

As a result of the neuropathologic process of Alzheimer's disease (AD), significant changes occur in neuromotor function (e.g., paratonia and compulsive grasping). These changes become manifest in the moderately severe stage of AD, when patients begin to require ongoing assistance with activities of daily life (ADL), and they are prominent in the severe stage of AD, when patients are continuously dependent on a caregiver. Patients in these stages often display behavioral disturbances during care activities. These disturbing behaviors result not only from cognitive impairment, but also from a patient's physical inability to cooperate with the caregiver. When care management strategies take into account the characteristic physical restrictions resulting from the neuromotor changes that accompany advanced AD, the caregiving process may be significantly facilitated.

scholarly journals Emotional Memory in Patients with Alzheimer’s Disease: A Report of Two Cases

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Akira Okada ◽  
Junko Matsuo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family Member ◽  
Long Memory ◽  
Daily Life ◽  
Emotional Memory ◽  
Memory Retention ◽  
Long Period ◽  
Emotional Events

Highly emotional events in daily life can be preserved in memory and such memory is generally referred to as emotional memory. Some reports have demonstrated that emotional memory is also found in patients with Alzheimer’s disease (AD). However, to our knowledge, there have been no reports about how long memory retention for emotional events can continue in patients with AD. In this paper, we present two patients with AD who lost an immediate family member during followup and retained the memory over a long period despite progression of the AD.

scholarly journals Antemortem Visit-To-Visit Blood Pressure Variability Predicts Cerebrovascular Lesion Burden in Autopsy-Confirmed Alzheimer’s Disease

2021 ◽  
pp. 1-11
Author(s):  
Isabel J. Sible ◽  
Katherine J. Bangen ◽  
Anna E. Blanken ◽  
Jean K. Ho ◽  
Daniel A. Nation
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Pressure ◽  
Alzheimer's Disease ◽  
Cerebrovascular Disease ◽  
Blood Pressure Variability ◽  
Cognitive Change ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Cerebrovascular Lesion

Background: Blood pressure variability is linked to Alzheimer’s disease (AD) risk and MRI-based markers of cerebrovascular disease. Less is known about the role of blood pressure variability in postmortem evaluation of cerebrovascular disease and AD. Objective: To determine whether antemortem blood pressure variability predicts cerebrovascular and AD pathology and follow-up cognitive change in autopsy-confirmed AD. Methods: National Alzheimer’s Coordinating Center participants (n = 513) underwent 3-4 approximately annual blood pressure measurements and were confirmed to have AD at postmortem evaluation. A subset (n = 493) underwent neuropsychological evaluation at follow-up. Regression models examined relationships between blood pressure variability and cerebrovascular and AD pathological features and follow-up cognitive change. Results: Elevated blood pressure variability predicted increased postmortem cerebrovascular lesion burden (ß = 0.26 [0.10, 0.42]; p = 0.001; R 2 = 0.12). Increased blood pressure variability predicted specific cerebrovascular lesion severity, including atherosclerosis in the Circle of Willis (OR = 1.22 [1.03, 1.44]; p = 0.02) and cerebral arteriolosclerosis (OR = 1.32 [1.04, 1.69]; p = 0.03). No significant relationships were observed between blood pressure variability and AD pathological findings, including Braak & Braak stage, neuritic plaques or diffuse plaques, or cerebral amyloid angiopathy, or follow-up cognitive decline. Conclusion: Findings suggest that elevated blood pressure variability is related to postmortem cerebrovascular lesion burden in autopsy-confirmed AD, independent of average blood pressure and AD neuropathology. Blood pressure fluctuation may selectively promote atherosclerotic and arteriolosclerotic brain lesions with potential implications for cognitive impairment and dementia.

scholarly journals The Effect of Light on Daily Life Activities and Sleep in Patients with Alzheimer’s Disease

2019 ◽  
Vol 6 (3) ◽  
pp. 59-64 ◽  
Author(s):  
Güler Balcı Alparslan ◽  
Ayşe Özkaraman ◽  
Demet Özbabalık ◽  
Ertuğrul Çolak
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Daily Life ◽  
Daily Life Activities ◽  
Effect Of Light

scholarly journals Daily social interactions related to daily performance on mobile cognitive tests among older adults

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256583
Author(s):  
Ruixue Zhaoyang ◽  
Stacey B. Scott ◽  
Lynn M. Martire ◽  
Martin J. Sliwinski
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Social Interactions ◽  
Cognitive Performance ◽  
Behavioral Interventions ◽  
Daily Life ◽  
Cognitive Tests

The lack of social contact or good social relationships has been linked with cognitive decline and higher risk for Alzheimer’s disease and related dementias. One important but unexamined question is how daily social interactions relate to older adults’ cognitive function in daily life. The present study examined how changes in daily social interactions related to fluctuations in older adults’ performance on mobile cognitive tests from day to day. Using an ecological momentary assessments approach, 312 older adults (aged 70 to 90 years) completed surveys on social interactions and mobile cognitive tests five times a day for 16 consecutive days using smartphones. Multilevel modeling was used for analyses. Results demonstrated that having more daily social interactions, especially more pleasant social interactions, related to better cognitive performance the same day and over the subsequent two days. Cognitive performance, however, did not predict subsequent changes in social interactions across days. At the between-person level, older adults who had more (vs. less) frequent interactions with close partners on average, especially with their friends, had better cognitive performance. Finally, the average levels of social interactions also moderated the within-person associations between daily social interactions and the same-day cognitive performance. In sum, results from this study highlight the importance of having pleasant social interactions and frequent interactions with friends for older adults’ cognitive function in daily life, and have important implications for future behavioral interventions targeting certain features of daily social interactions to reduce risk of cognitive decline and Alzheimer’s disease and related dementias.

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