TU11. THE GENETIC RELATIONSHIP BETWEEN THE FTO RS9939609 POLYMORPHISM, BODY MASS INDEX AND ANXIETY DISORDERS IN A SPANISH POPULATION-BASED COHORT

Background: Few large studies have examined correlations between anxiety and body mass index (BMI) by gender or racial groups using clinical data. Objective: This study aimed to determine associations between diagnosed anxiety disorders and BMI, and evaluate whether observed associations varied by demographic characteristics. Method: Data from the Rochester Epidemiology Project (REP) data linkage system were analyzed to examine associations between anxiety disorders and BMI among adults ages 18-85 residing in Olmsted County, MN in 2009 (n=103,557). Height and weight data were available for 75,958 people (73%). The international classification of underweight, overweight, and obesity by BMI was used. Results: Population consisted of 56% females, 92.8% White individuals, with median age of 46 years. When adjusted for age, sex, and race, we observed a U-shaped association between anxiety and BMI group. Underweight and obese individuals were more likely to have an anxiety diagnosis compared to normal weight individuals. Stratification by sex yielded a U-shaped association between anxiety and BMI only in women. Stratification by race showed a U-shaped association between anxiety and BMI only in the White population. Anxiety was significantly associated only with obesity in the Black population. Anxiety was not associated with a BMI category in Asian or Hispanic groups. Among elderly group, there is inverse correlation between anxiety and obesity. Conclusion: Our results suggest that anxiety may have heterogeneous associations with BMI in the population. Further research on potential mechanisms contributing to these findings will help direct efforts in anxiety and obesity management across diverse population groups.

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1480: The Association of Body Mass Index and Serum Prostate Specific Antigen Levels in a Population-Based Study

The Journal of Urology ◽

10.1016/s0022-5347(18)35614-3 ◽

2005 ◽

Vol 173 (4S) ◽

pp. 401-401

Author(s):

Javier Hernandez ◽

Jacques Baillargeon ◽

Brad Pollock ◽

Alan R. Kristal ◽

Patrick Bradshaw ◽

...

Keyword(s):

Body Mass Index ◽

Prostate Specific Antigen ◽

Body Mass ◽

Specific Antigen ◽

Population Based ◽

Population Based Study ◽

Serum Prostate Specific Antigen

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Faculty Opinions recommendation of Diabetes and body mass index in relation to risk of active tuberculosis: a prospective population-based cohort.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737293826.793570593 ◽

2020 ◽

Author(s):

Anthony Harries ◽

Kudakwashe C Takarinda

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Population Based ◽

Active Tuberculosis

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Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study

BMJ ◽

10.1136/bmj.n365 ◽

2021 ◽

pp. n365

Author(s):

Buyun Liu ◽

Yang Du ◽

Yuxiao Wu ◽

Linda G Snetselaar ◽

Robert B Wallace ◽

...

Keyword(s):

Body Mass Index ◽

Waist Circumference ◽

Ethnic Groups ◽

Body Mass ◽

Body Fat ◽

Lean Mass ◽

The United States ◽

Population Based ◽

Body Fat Percentage ◽

Fat Percentage

AbstractObjectiveTo examine the trends in obesity and adiposity measures, including body mass index, waist circumference, body fat percentage, and lean mass, by race or ethnicity among adults in the United States from 2011 to 2018.DesignPopulation based study.SettingNational Health and Nutrition Examination Survey (NHANES), 2011-18.ParticipantsA nationally representative sample of US adults aged 20 years or older.Main outcome measuresWeight, height, and waist circumference among adults aged 20 years or older were measured by trained technicians using standardized protocols. Obesity was defined as body mass index of 30 or higher for non-Asians and 27.5 or higher for Asians. Abdominal obesity was defined as a waist circumference of 102 cm or larger for men and 88 cm or larger for women. Body fat percentage and lean mass were measured among adults aged 20-59 years by using dual energy x ray absorptiometry.ResultsThis study included 21 399 adults from NHANES 2011-18. Body mass index was measured for 21 093 adults, waist circumference for 20 080 adults, and body fat percentage for 10 864 adults. For the overall population, age adjusted prevalence of general obesity increased from 35.4% (95% confidence interval 32.5% to 38.3%) in 2011-12 to 43.4% (39.8% to 47.0%) in 2017-18 (P for trend<0.001), and age adjusted prevalence of abdominal obesity increased from 54.5% (51.2% to 57.8%) in 2011-12 to 59.1% (55.6% to 62.7%) in 2017-18 (P for trend=0.02). Age adjusted mean body mass index increased from 28.7 (28.2 to 29.1) in 2011-12 to 29.8 (29.2 to 30.4) in 2017-18 (P for trend=0.001), and age adjusted mean waist circumference increased from 98.4 cm (97.4 to 99.5 cm) in 2011-12 to 100.5 cm (98.9 to 102.1 cm) in 2017-18 (P for trend=0.01). Significant increases were observed in body mass index and waist circumference among the Hispanic, non-Hispanic white, and non-Hispanic Asian groups (all P for trend<0.05), but not for the non-Hispanic black group. For body fat percentage, a significant increase was observed among non-Hispanic Asians (30.6%, 29.8% to 31.4% in 2011-12; 32.7%, 32.0% to 33.4% in 2017-18; P for trend=0.001), but not among other racial or ethnic groups. The age adjusted mean lean mass decreased in the non-Hispanic black group and increased in the non-Hispanic Asian group, but no statistically significant changes were found in other racial or ethnic groups.ConclusionsAmong US adults, an increasing trend was found in obesity and adiposity measures from 2011 to 2018, although disparities exist among racial or ethnic groups.

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Body mass index and breast cancer risk in Japan: a pooled analysis of eight population-based cohort studies

Annals of Oncology ◽

10.1093/annonc/mdt542 ◽

2014 ◽

Vol 25 (2) ◽

pp. 519-524 ◽

Cited By ~ 31

Author(s):

K. Wada ◽

C. Nagata ◽

A. Tamakoshi ◽

K. Matsuo ◽

I. Oze ◽

...

Keyword(s):

Breast Cancer ◽

Body Mass Index ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Cohort Studies ◽

Body Mass ◽

Population Based ◽

Pooled Analysis

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Prevalence of varicocoele and its association with body mass index among 39,559 rural men in eastern China: a population-based cross-sectional study

Andrology ◽

10.1111/andr.12345 ◽

2017 ◽

Vol 5 (3) ◽

pp. 562-567 ◽

Cited By ~ 5

Author(s):

J. Liu ◽

S. Zhang ◽

M. Liu ◽

Q. Wang ◽

H. Shen ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Eastern China ◽

Population Based ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Well-Being and the Lifestyle Habits of the Spanish Population: The Association between Subjective Well-Being and Eating Habits

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18041553 ◽

2021 ◽

Vol 18 (4) ◽

pp. 1553

Author(s):

Laura Cabiedes-Miragaya ◽

Cecilia Diaz-Mendez ◽

Isabel García-Espejo

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Eating Habits ◽

Perceived Health ◽

Well Being ◽

Spanish Population ◽

Sociological Research ◽

Subjective Well Being ◽

Lifestyle Habits ◽

Independent Variables

The so-called Mediterranean diet is not simply a collection of foodstuffs but an expression of the culture of the countries of the south of Europe, declared Intangible Cultural Heritage by UNESCO. Despite the link between food and culture, little has been studied about how diet contributes to the well-being of the population. This article aims to analyze the association between subjective well-being and the eating habits of the Spanish population in order to gain a better understanding of the subjective well-being that food culture produces. For this study, we used a representative sample of the Spanish adult population from a survey by the Sociological Research Center (CIS 2017). Three indicators of subjective well-being were used: perceived health, life satisfaction, and feeling of happiness. The independent variables relating to eating habits considered in the analysis were, among others, how often meat, fish, vegetables, fruit, and sweets were consumed; how the food was prepared; how often meals were eaten out at restaurants or cafés and how often they were eaten with family or friends. Other independent variables related to lifestyle habits were also included in the analysis, in particular, physical exercise and body mass index. We used ordinal logistic regressions and multiple linear regression models. Our findings coincide in large measure with those obtained in earlier studies where perceived health and income play a key role in evaluating subjective well-being. In turn, several variables related to lifestyle habits, such as consuming sweets and fruits, social interaction around meals, exercising, and body mass index, were also associated with subjective well-being.

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The association of body mass index, weight gain and central obesity with activity-related breathlessness: the Swedish Cardiopulmonary Bioimage Study

Thorax ◽

10.1136/thoraxjnl-2019-213349 ◽

2019 ◽

Vol 74 (10) ◽

pp. 958-964 ◽

Cited By ~ 4

Author(s):

Magnus Pär Ekström ◽

Anders Blomberg ◽

Göran Bergström ◽

John Brandberg ◽

Kenneth Caidahl ◽

...

Keyword(s):

Body Mass Index ◽

Weight Gain ◽

Body Mass ◽

Lung Volume ◽

Airflow Obstruction ◽

Adult Life ◽

Population Based ◽

Obese Women ◽

Adverse Health Outcomes ◽

Lower Lung

IntroductionBreathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m2) is rapidly increasing globally and its impact on breathlessness is unclear.MethodsThis population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessness (modified Research Council score ≥1) in the middle-aged population. Secondary aims were to evaluate factors that contribute to breathlessness in obesity, including the interaction with spirometric lung volume and sex.ResultsWe included 13 437 individuals; mean age 57.5 years; 52.5% women; mean BMI 26.8 (SD 4.3); mean BMI increase since age 20 was 5.0 kg/m2; and 1283 (9.6%) reported breathlessness. Obesity was strongly associated with increased breathlessness, OR 3.54 (95% CI, 3.03 to 4.13) independent of age, sex, smoking, airflow obstruction, exercise level and the presence of comorbidities. The association between BMI and breathlessness was modified by lung volume; the increase in breathlessness prevalence with higher BMI was steeper for individuals with lower forced vital capacity (FVC). The higher breathlessness prevalence in obese women than men (27.4% vs 12.5%; p<0.001) was related to their lower FVC. Irrespective of current BMI and confounders, individuals who had increased in BMI since age 20 had more breathlessness.ConclusionBreathlessness is independently associated with obesity and with weight gain in adult life, and the association is stronger for individuals with lower lung volumes.

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Body Mass Index and Depressive Symptoms: Testing for Adverse and Protective Associations in Two Twin Cohort Studies

Twin Research and Human Genetics ◽

10.1017/thg.2016.14 ◽

2016 ◽

Vol 19 (4) ◽

pp. 306-311 ◽

Cited By ~ 7

Author(s):

Markus Jokela ◽

Venla Berg ◽

Karri Silventoinen ◽

G. David Batty ◽

Archana Singh-Manoux ◽

...

Keyword(s):

Body Mass Index ◽

Depressive Symptoms ◽

Cohort Studies ◽

Body Mass ◽

Genetic Model ◽

The United States ◽

Population Based ◽

The Us ◽

Mz Twins ◽

Pair Analysis

Studies have suggested both adverse and protective associations of obesity with depressive symptoms. We examined the contribution of environmental and heritable factors in this association. Participants were same-sex twin pairs from two population-based twin cohort studies, the Older Finnish Twin Cohort (n = 8,215; mean age = 44.1) and the US Midlife Development in the United States (MIDUS; n = 1,105; mean age = 45.1). Body mass index (BMI) was calculated from self-reported height and weight. Depressive symptoms were assessed using Beck's Depression Inventory (BDI; Finnish Twin Cohort), and by negative and positive affect scales (MIDUS). In the Finnish Twin Cohort, higher BMI was associated with higher depressive symptoms in monozygotic (MZ) twins (B = 2.01, 95% CI = 1.0, 3.0) and dizygotic (DZ) twins (B = 1.17, 0.5, 1.9) with BMI >22. This association was observed in within-pair analysis in DZ twins (B = 1.47, CI = 0.4, 2.6) but not in within-pair analysis of MZ twins (B = 0.03, CI = -1.9, 2.0). Consistent with the latter result, a bivariate genetic model indicated that the association between higher BMI and higher depressive symptoms was largely mediated by genetic factors. The results of twin-pair analysis and bivariate genetic model were replicated in the MIDUS sample. These findings suggest an association between obesity and higher depressive symptoms, which is largely explained by shared heritable biological mechanisms.

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