P.0872 The association between childhood trauma discordance and suicide ideation among monozygotic and dizygotic twins

Objectives: Suicide is a leading cause of mortality worldwide. Dysregulated hypothalamic-pituitary-adrenal axis activity, as measured by cortisol levels, has been identified as one potential risk factor. Evidence has indicated that childhood trauma is associated with dysregulated cortisol reactivity to stress in adulthood. The current study investigated for the first time whether childhood trauma and daily stressors and emotions were associated with diurnal cortisol levels over a 7-day study in individuals vulnerable to suicide. Methods: 142 participants were categorized according to their suicidal history into three groups: suicide attempt, suicidal ideation or control group. Participants completed questionnaires before commencing a 7-day study. Cortisol samples were provided immediately upon waking, at 15 mins, 30 mins, 45 mins, 3 hours, 6 hours, 9 hours and 12 hours on 7 consecutive days. Measures of daily stressors, mood, defeat and entrapment were completed at the end of each day. Results: Participants in the suicide attempt and ideation groups released significantly lower cortisol upon awakening (CAR) and had a tendency towards flatter wake-peak to 12 hour (WP-12) cortisol slopes compared to controls. Childhood trauma was found to be associated with significantly lower CAR and a tendency towards flatter WP-12 cortisol slope. Childhood trauma also had an indirect effect on suicide vulnerability group membership via lower daily CAR levels. Lower CAR was associated with increased suicide ideation at 1-month but not 6-months. Daily stress and emotion measures were not associated with cortisol levels. Conclusions: This is the first 7-day daily diary investigation of naturally fluctuating cortisol levels in individuals vulnerable to suicide. The results indicate that dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity is associated with suicidal ideation and behavior. Childhood trauma appears to be an important distal factor associated with HPA-axis dysregulation.

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The relation of childhood trauma to suicide ideation in patients suffering from obsessive-compulsive disorder with lifetime suicide attempts

Psychiatry Research ◽

10.1016/j.psychres.2017.05.032 ◽

2017 ◽

Vol 255 ◽

pp. 139-145 ◽

Cited By ~ 21

Author(s):

Vahid Khosravani ◽

Zoleikha Kamali ◽

Razieh Jamaati Ardakani ◽

Mehdi Samimi Ardestani

Keyword(s):

Obsessive Compulsive Disorder ◽

Childhood Trauma ◽

Suicide Ideation ◽

Suicide Attempts ◽

Obsessive Compulsive ◽

Compulsive Disorder

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Associations of Discrimination, Suicide Ideation Severity and Attempts, and Depressive Symptoms Among Sexual and Gender Minority Youth

Crisis ◽

10.1027/0227-5910/a000718 ◽

2020 ◽

pp. 1-8

Author(s):

Adeline Wyman Battalen ◽

Ethan Mereish ◽

Jennifer Putney ◽

Christina M. Sellers ◽

Melinda Gushwa ◽

...

Keyword(s):

Depressive Symptoms ◽

Suicidal Ideation ◽

Childhood Trauma ◽

Suicide Ideation ◽

Suicide Attempts ◽

Thwarted Belongingness ◽

Perceived Burdensomeness ◽

Sociodemographic Variables ◽

Sexual And Gender Minority ◽

And Gender

Abstract. We examined the unique associations among discrimination, suicidal thoughts, suicide attempts, and depressive symptoms in a sample of sexual and gender minority (SGM) youth as well as interpersonal mediators of these associations. Participants included 94 SGM youth ( Mage = 18; SD = 2.88) recruited from SGM-specific drop-in centers. We used mediation analyses to test the mediating effects of perceived burdensomeness and thwarted belongingness on the associations between discrimination and suicidal ideation, suicide attempts, and depressive symptoms, accounting for childhood trauma and sociodemographic variables (age, gender identity, race, and sexual orientation). Within our nonclinical community sample of SGM youth, 49% reported a lifetime suicide attempt, 84% reported current suicide ideation, and 82% reported current depressive symptoms. Experiencing discrimination was associated with greater likelihood of suicide attempts and depressive symptoms, and greater perceived burdensomeness and thwarted belongingness, over and above the effects of childhood trauma and sociodemographic variables. Discrimination was indirectly associated with greater depressive symptoms through perceived burdensomeness and thwarted belongingness, and with greater severity of suicidal ideation through perceived burdensomeness. Findings suggest clinicians should assess for discrimination and include a focus on perceived burdensomeness and thwarted belongingness as targets of intervention for suicide and depression.

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Psychache, unmet interpersonal needs, childhood trauma and suicide ideation in young adults

Death Studies ◽

10.1080/07481187.2020.1788670 ◽

2020 ◽

pp. 1-10

Author(s):

Joana Spínola ◽

Rui C. Campos ◽

Diandra Marques ◽

Ronald R. Holden

Keyword(s):

Young Adults ◽

Childhood Trauma ◽

Suicide Ideation ◽

Interpersonal Needs

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Suicide ideation versus suicide attempt: Examining overlapping and differential determinants in a large cohort of patients with depression and/or anxiety

Australian & New Zealand Journal of Psychiatry ◽

10.1177/0004867420951256 ◽

2020 ◽

pp. 000486742095125

Author(s):

Jasper XM Wiebenga ◽

Merijn Eikelenboom ◽

Henriette D Heering ◽

Patricia van Oppen ◽

Brenda WJH Penninx

Keyword(s):

Anxiety Disorder ◽

Suicide Attempt ◽

Childhood Trauma ◽

Suicide Ideation ◽

Age Of Onset ◽

Depression And Anxiety ◽

Psychosocial Characteristics ◽

Younger Age ◽

Lower Education ◽

Suicidal Patients

Objective: Individuals with a depressive and/or anxiety disorder are known to have an elevated risk of suicide. However, these diagnoses alone are insufficient at differentiating patients with suicide ideation that attempt suicide from those that do not. Few studies examined such differences in an ideation-to-action framework. Using this framework, extensive multivariate testing was performed to examine differences between suicidal patients with and without a suicide attempt. Method: Data were from 1576 respondents with a depressive and/or anxiety disorder, participating in the Netherlands Study of Depression and Anxiety. Logistic regression analyses were used to analyze associations between sociodemographic, clinical, personality, and psychosocial risk factors and suicide ideation and attempt. Results: Patients with suicide ideation could be uniquely distinguished from non-suicidal patients by more years of education, presence of a depressive disorder (vs anxiety disorder) and higher introversion. Patients with suicide ideation and a past suicide attempt could be uniquely distinguished from non-suicidal patients by a younger age of onset, a lifetime alcohol use disorder, more external locus of control and lower levels of social support. Within the group of patients with suicide ideation, patients with a suicide attempt were more likely to have childhood trauma and lower education, and be of non-Western descent than patients with suicide ideation and no past attempt. Conclusion: This study found that although various clinical, personality and psychosocial characteristics distinguish patients with suicide ideation from non-suicidal patients, many of these often-cited factors do not distinguish patients with a suicide attempt from those who only think about suicide. However, childhood trauma, lower education and non-Western descent could aid in detecting suicide attempt risk among patients with suicide ideation.

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Functions of Nonsuicidal Self-Injury Are Differentially Associated with Suicide Ideation and Past Attempts among Childhood Trauma Survivors

Suicide and Life-Threatening Behavior ◽

10.1111/sltb.12306 ◽

2016 ◽

Vol 47 (4) ◽

pp. 450-460 ◽

Cited By ~ 2

Author(s):

Michelle E. Roley-Roberts ◽

Melissa J. Zielinski ◽

Gabriela Hurtado ◽

Joseph D. Hovey ◽

Jon D. Elhai

Keyword(s):

Childhood Trauma ◽

Suicide Ideation ◽

Trauma Survivors ◽

Self Injury ◽

Nonsuicidal Self Injury

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F60. ADDICTIVE EFFECT OF CHILDHOOD TRAUMA AND RECENT STRESSFUL EVENTS AS PREDICTORS FOR CURRENT SUICIDE IDEATION IN SCHIZOPHRENIA

Schizophrenia Bulletin ◽

10.1093/schbul/sbz018.472 ◽

2019 ◽

Vol 45 (Supplement_2) ◽

pp. S277-S277

Author(s):

Vincenzo De Luca ◽

Hwang Liang-Ching

Keyword(s):

Childhood Trauma ◽

Suicide Ideation ◽

Stressful Events

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The Relationship Between Childhood Trauma and Suicide Ideation: Mediating Role of Mental Pain

Annals of Military and Health Sciences Research ◽

10.5812/amh.89266 ◽

2019 ◽

Vol In Press (In Press) ◽

Cited By ~ 1

Author(s):

Iran Zarrati ◽

Hamed Bermas ◽

Mehrdad Sabet

Keyword(s):

Childhood Trauma ◽

Suicide Ideation ◽

Mental Pain ◽

Mediating Role ◽

The Relationship

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Is There a Major Role for Undetected Autism Spectrum Disorder with Childhood Trauma in a Patient with a Diagnosis of Bipolar Disorder, Self-Injuring, and Multiple Comorbidities?

Case Reports in Psychiatry ◽

10.1155/2019/4703795 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Claudia Carmassi ◽

Carlo Antonio Bertelloni ◽

Gianluca Salarpi ◽

Elisa Diadema ◽

Maria Teresa Avella ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Bipolar Disorder ◽

Childhood Trauma ◽

Suicide Ideation ◽

Depressive Symptomatology ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Psychiatric Clinic ◽

Autism Spectrum Quotient ◽

Response Scale

This case report highlights the relevance of the consequences of trauma in a female patient with an undetected autism spectrum disorder (ASD) affected by bipolar disorder (BD) with multiple comorbidities. A 35-year-old woman with BD type II, binge eating disorder and panic disorder was admitted in the Inpatient Unit of the Psychiatric Clinic of the University of Pisa because of a recrudescence of depressive symptomatology, associated with increase of anxiety, noticeable ruminations, significant alteration in neurovegetative pattern, and serious suicide ideation. During the hospitalization, a diagnosis of ASD emerged besides a history of childhood trauma and affective dysregulation, marked impulsivity, feeling of emptiness, and self-harm behavior. The patient was assessed by the Autism-Spectrum Quotient (AQ), Ritvo Autism and Asperger Diagnostic Scale (RAADS-R), the Adult Autism Subthreshold Spectrum (AdAS Spectrum), Trauma and Loss Spectrum (TALS-SR), and Ruminative Response Scale (RRS). Total scores of 38/50 in the AQ, 146/240 in the RAADS-R, 99/160 in the AdAS Spectrum emerged, compatible with ASD, 47/116 in the TALS-SR, and 64/88 in the RRS. We discuss the implications of the trauma she underwent during her childhood, in the sense that caused a complex posttraumatic disorder, a lifelong disease favored and boosted by the rumination tendency of high functioning ASD.

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