Decrease in prolactine levels after treatment with aripiprazole during a maniac episode: A case report

IntroductionHyperprolactinemia can produce clinical symptoms affecting the patient's quality of life and therefore limiting therapeutic approaches to bipolar disorder.Case reportWe report a case of a 46-year-old woman, with a 10 year history of type I bipolar disorder and a microprolactinoma, who was admitted to a psychiatry inpatient unit due to a maniac episode. Current symptoms at the moment of admission included hyperthymia, verbiage, flight of ideas and insomnia. Menstrual changes and galactorrea had been present previously. Aripiprazole was introduced, reaching a dose of 30 mg/day, in addition to her usual treatment with lithium and gabapentin. Response to treatment was good and euthymia was reached within 10 days. Moreover, gabapentin was substituted by Valproic acid, and the patient was discharged once therapeutic levels were attained. Prolactin levels were measured at the moment of admission (128.75 ng/mL) and after 11 days of treatment (92.93 ng/mL).DiscussionChoosing an adequate antipsychotic agent can reduce the risk of iatrogenesis and thus enhance adherence to treatment and quality of life. Aripiprazole had previously shown a high potential at decreasing levels of prolactine. In this case, clinical practice supports scientific evidence.ConclusionsAripiprazole is an effective treatment for type I bipolar disorder. Especially, it can be a treatment of choice in patients suffering from symptoms related to high levels of prolactine, even using a high dosage.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Subthreshold Manifestations of Bipolar Disorders as Health Care’s tool

European Psychiatry ◽

10.1016/s0924-9338(09)70820-x ◽

2009 ◽

Vol 24 (S1) ◽

pp. 1-1

Author(s):

M. Mazza ◽

D. Harnic ◽

G. Marano ◽

V. Catalano ◽

L. Janiri ◽

...

Keyword(s):

Quality Of Life ◽

Bipolar Disorder ◽

Bipolar Disorders ◽

Unipolar Depression ◽

Response To Treatment ◽

Type I ◽

Male Patients ◽

Bipolar Patients ◽

Disorder Type

Introdution:Our study represents a pilot evaluation about how the MOOD-SR recognizes subthreshold manifestations that may be associated with clinical symptomatology in a group of bipolar patients.Methods:At Day Hospital of Psychiatry, Policlinico “A. Gemelli”, Bipolar Disorders Unit, it has been conducted an experimental study on a heterogeneous sample of 24 patients with a diagnosis of Bipolar Disorder type I. Patients have been assessed with the MOOD-SR, a clinical self-reported interview, that is specific for the spectrum of subthreshold pathology, and with the Quality of Life (QoL), that investigates the patient's quality of life.Results:We have found that 16 patients on 24 report a score higher than 60 (68,4%). Among these, 10 female patients on 15 have a total score higer than 61 (68.75%) while 6 male patients on 9 obtain a total score higher than 60 (62,5%). However, these results have only preliminary value, further studies are needed in order to obtain a deeper evaluation.Conclusion:Spectrum manifestations are both indicator of course and response to treatment and predictive for relapse. This finding may represent an important preventive instrument for maniacal relapse in patients with Bipolar Disorder, that is often underdiagnosed or confused for Unipolar Depression. By adequately recognizing the problem we will be able to refine diagnosis and individualize therapy.

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Quality of Life and Global Functioning Among Chronic Type I Bipolar Disorder Patients in Comparison With a General Population in Iran

Asian Journal of Biological Sciences ◽

10.3923/ajbs.2009.29.34 ◽

2008 ◽

Vol 2 (1) ◽

pp. 29-34 ◽

Cited By ~ 2

Author(s):

S.H. Hosseini ◽

M. Karkhaneh Yousefi

Keyword(s):

Quality Of Life ◽

Bipolar Disorder ◽

General Population ◽

Type I ◽

Chronic Type ◽

Global Functioning

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Suicide attempts are associated with worse quality of life in patients with bipolar disorder type I

Comprehensive Psychiatry ◽

10.1016/j.comppsych.2011.03.003 ◽

2012 ◽

Vol 53 (2) ◽

pp. 125-129 ◽

Cited By ~ 29

Author(s):

Lena Nabuco de Abreu ◽

Fabiano G. Nery ◽

Jill M. Harkavy-Friedman ◽

Karla Matias de Almeida ◽

Bernardo Carramao Gomes ◽

...

Keyword(s):

Quality Of Life ◽

Bipolar Disorder ◽

Suicide Attempts ◽

Type I ◽

Disorder Type

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History of suicide attempts in patients with bipolar disorder type I: socio-demographic and clinical factors, quality of life and functioning

Nordic Journal of Psychiatry ◽

10.1080/08039488.2020.1853230 ◽

2020 ◽

pp. 1-8

Author(s):

Vitor Fernandes de Almeida ◽

Severino Bezerra-Filho ◽

Paula Studart-Bottó ◽

Gabriela Léda-Rego ◽

Ivã Taiuan Fialho Silva ◽

...

Keyword(s):

Quality Of Life ◽

Bipolar Disorder ◽

Suicide Attempts ◽

Type I ◽

Clinical Factors ◽

History Of ◽

Disorder Type

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Neuropsychological performance in euthymic Indian patients with bipolar disorder type I: Correlation between quality of life and global functioning

Psychiatry and Clinical Neurosciences ◽

10.1111/j.1440-1819.2012.02400.x ◽

2012 ◽

Vol 66 (7) ◽

pp. 553-563 ◽

Cited By ~ 17

Author(s):

Raman Deep Pattanayak ◽

Rajesh Sagar ◽

Manju Mehta

Keyword(s):

Quality Of Life ◽

Bipolar Disorder ◽

Neuropsychological Performance ◽

Type I ◽

Global Functioning ◽

Indian Patients ◽

Disorder Type

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Perceived Quality of Life in Patients with Bipolar Disorder. Does Group Psychoeducation Have an Impact?

The Canadian Journal of Psychiatry ◽

10.1177/070674370505000204 ◽

2005 ◽

Vol 50 (2) ◽

pp. 95-100 ◽

Cited By ~ 49

Author(s):

Erin E Michalak ◽

Lakshmi N Yatham ◽

Dante DC Wan ◽

Raymond W Lam

Keyword(s):

Quality Of Life ◽

Bipolar Disorder ◽

Physical Functioning ◽

Large Body ◽

Well Being ◽

Type I ◽

Treatment Intervention ◽

General Satisfaction ◽

The Impact

Objective: A large body of research has now accumulated concerning quality of life (QoL) for patients with major depressive disorder, both in terms of describing levels of well-being and in terms of assessing the impact of treatment interventions. However, there is little information concerning QoL for patients with bipolar disorder (BD), and there is relatively little published evidence concerning the effectiveness of psychological interventions for BD. We aimed to assess the impact of a time-limited psychoeducation (PE) group therapy upon perceived QoL among patients with BD. Method: Participants were patients ( n = 57) with BD type I or II who were clinically described as euthymic or mildly symptomatic. Treatment intervention was a standardized, 8-week group PE course delivered in a mood disorders program in British Columbia, Canada. Using retrospective chart review and the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), we assessed QoL at baseline and at 8 weeks. Results: Mean baseline Q-LES-Q scores were 56%, representing moderate impairment in QoL. Group PE was associated with a 5-point increase in Q-LES-Q scores (where higher scores indicate better QoL). Examination of the questionnaire's subscales revealed that 2 domains (that is, physical functioning and general satisfaction) increased significantly following PE, with the remaining domains showing nonsignificant trends toward improved functioning. Multivariate analysis indicated that only one factor (having had a recent episode of depression) significantly predicted pre- and posttreatment Q-LES-Q scores. Conclusion: Patients with BD continue to show impaired QoL even when clinically euthymic. Although preliminary, our results show that group PE is associated with improved QoL in this population, both in terms of general satisfaction and in relation to levels of physical functioning. The use of PE as an adjunct to pharmacotherapy in BD should be further studied with particular emphasis on characterizing the effects of treatment intervention on perceived QoL.

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Misophonia: An Evidence-Based Case Report

American Journal of Audiology ◽

10.1044/2020_aja-19-00111 ◽

2020 ◽

Vol 29 (4) ◽

pp. 685-690

Author(s):

C. S. Vanaja ◽

Miriam Soni Abigail

Keyword(s):

Quality Of Life ◽

Case Report ◽

Case History ◽

Pure Tone ◽

Physiological Responses ◽

Evidence Based ◽

Management Option ◽

Pure Tone Audiogram

Purpose Misophonia is a sound tolerance disorder condition in certain sounds that trigger intense emotional or physiological responses. While some persons may experience misophonia, a few patients suffer from misophonia. However, there is a dearth of literature on audiological assessment and management of persons with misophonia. The purpose of this report is to discuss the assessment of misophonia and highlight the management option that helped a patient with misophonia. Method A case study of a 26-year-old woman with the complaint of decreased tolerance to specific sounds affecting quality of life is reported. Audiological assessment differentiated misophonia from hyperacusis. Management included retraining counseling as well as desensitization and habituation therapy based on the principles described by P. J. Jastreboff and Jastreboff (2014). A misophonia questionnaire was administered at regular intervals to monitor the effectiveness of therapy. Results A detailed case history and audiological evaluations including pure-tone audiogram and Johnson Hyperacusis Index revealed the presence of misophonia. The patient benefitted from intervention, and the scores of the misophonia questionnaire indicated a decrease in the severity of the problem. Conclusions It is important to differentially diagnose misophonia and hyperacusis in persons with sound tolerance disorders. Retraining counseling as well as desensitization and habituation therapy can help patients who suffer from misophonia.

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