Suicide attempts are associated with worse quality of life in patients with bipolar disorder type I

Introdution:Our study represents a pilot evaluation about how the MOOD-SR recognizes subthreshold manifestations that may be associated with clinical symptomatology in a group of bipolar patients.Methods:At Day Hospital of Psychiatry, Policlinico “A. Gemelli”, Bipolar Disorders Unit, it has been conducted an experimental study on a heterogeneous sample of 24 patients with a diagnosis of Bipolar Disorder type I. Patients have been assessed with the MOOD-SR, a clinical self-reported interview, that is specific for the spectrum of subthreshold pathology, and with the Quality of Life (QoL), that investigates the patient's quality of life.Results:We have found that 16 patients on 24 report a score higher than 60 (68,4%). Among these, 10 female patients on 15 have a total score higer than 61 (68.75%) while 6 male patients on 9 obtain a total score higher than 60 (62,5%). However, these results have only preliminary value, further studies are needed in order to obtain a deeper evaluation.Conclusion:Spectrum manifestations are both indicator of course and response to treatment and predictive for relapse. This finding may represent an important preventive instrument for maniacal relapse in patients with Bipolar Disorder, that is often underdiagnosed or confused for Unipolar Depression. By adequately recognizing the problem we will be able to refine diagnosis and individualize therapy.

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Neuropsychological performance in euthymic Indian patients with bipolar disorder type I: Correlation between quality of life and global functioning

Psychiatry and Clinical Neurosciences ◽

10.1111/j.1440-1819.2012.02400.x ◽

2012 ◽

Vol 66 (7) ◽

pp. 553-563 ◽

Cited By ~ 17

Author(s):

Raman Deep Pattanayak ◽

Rajesh Sagar ◽

Manju Mehta

Keyword(s):

Quality Of Life ◽

Bipolar Disorder ◽

Neuropsychological Performance ◽

Type I ◽

Global Functioning ◽

Indian Patients ◽

Disorder Type

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Quality of Life and Global Functioning Among Chronic Type I Bipolar Disorder Patients in Comparison With a General Population in Iran

Asian Journal of Biological Sciences ◽

10.3923/ajbs.2009.29.34 ◽

2008 ◽

Vol 2 (1) ◽

pp. 29-34 ◽

Cited By ~ 2

Author(s):

S.H. Hosseini ◽

M. Karkhaneh Yousefi

Keyword(s):

Quality Of Life ◽

Bipolar Disorder ◽

General Population ◽

Type I ◽

Chronic Type ◽

Global Functioning

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Lifetime history of suicide attempts is associated with poorer social skills in patients with bipolar disorder type I

Brazilian Journal of Psychiatry ◽

10.1590/s1516-44462010000200021 ◽

2010 ◽

Vol 32 (2) ◽

pp. 200-201 ◽

Cited By ~ 2

Author(s):

Cristiana Castanho de Almeida Rocca ◽

Luciana Gerchmann ◽

Lena Nabuco de Abreu ◽

Beny Lafer

Keyword(s):

Bipolar Disorder ◽

Social Skills ◽

Suicide Attempts ◽

Type I ◽

Lifetime History ◽

History Of ◽

Disorder Type

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Decrease in prolactine levels after treatment with aripiprazole during a maniac episode: A case report

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.1166 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S333-S334

Author(s):

J.M. Coll ◽

G. Martínez-Alés ◽

N. Salgado

Keyword(s):

Quality Of Life ◽

Bipolar Disorder ◽

Case Report ◽

Clinical Symptoms ◽

Scientific Evidence ◽

Antipsychotic Agent ◽

Response To Treatment ◽

Type I ◽

The Moment

IntroductionHyperprolactinemia can produce clinical symptoms affecting the patient's quality of life and therefore limiting therapeutic approaches to bipolar disorder.Case reportWe report a case of a 46-year-old woman, with a 10 year history of type I bipolar disorder and a microprolactinoma, who was admitted to a psychiatry inpatient unit due to a maniac episode. Current symptoms at the moment of admission included hyperthymia, verbiage, flight of ideas and insomnia. Menstrual changes and galactorrea had been present previously. Aripiprazole was introduced, reaching a dose of 30 mg/day, in addition to her usual treatment with lithium and gabapentin. Response to treatment was good and euthymia was reached within 10 days. Moreover, gabapentin was substituted by Valproic acid, and the patient was discharged once therapeutic levels were attained. Prolactin levels were measured at the moment of admission (128.75 ng/mL) and after 11 days of treatment (92.93 ng/mL).DiscussionChoosing an adequate antipsychotic agent can reduce the risk of iatrogenesis and thus enhance adherence to treatment and quality of life. Aripiprazole had previously shown a high potential at decreasing levels of prolactine. In this case, clinical practice supports scientific evidence.ConclusionsAripiprazole is an effective treatment for type I bipolar disorder. Especially, it can be a treatment of choice in patients suffering from symptoms related to high levels of prolactine, even using a high dosage.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Perceived Quality of Life in Patients with Bipolar Disorder. Does Group Psychoeducation Have an Impact?

The Canadian Journal of Psychiatry ◽

10.1177/070674370505000204 ◽

2005 ◽

Vol 50 (2) ◽

pp. 95-100 ◽

Cited By ~ 49

Author(s):

Erin E Michalak ◽

Lakshmi N Yatham ◽

Dante DC Wan ◽

Raymond W Lam

Keyword(s):

Quality Of Life ◽

Bipolar Disorder ◽

Physical Functioning ◽

Large Body ◽

Well Being ◽

Type I ◽

Treatment Intervention ◽

General Satisfaction ◽

The Impact

Objective: A large body of research has now accumulated concerning quality of life (QoL) for patients with major depressive disorder, both in terms of describing levels of well-being and in terms of assessing the impact of treatment interventions. However, there is little information concerning QoL for patients with bipolar disorder (BD), and there is relatively little published evidence concerning the effectiveness of psychological interventions for BD. We aimed to assess the impact of a time-limited psychoeducation (PE) group therapy upon perceived QoL among patients with BD. Method: Participants were patients ( n = 57) with BD type I or II who were clinically described as euthymic or mildly symptomatic. Treatment intervention was a standardized, 8-week group PE course delivered in a mood disorders program in British Columbia, Canada. Using retrospective chart review and the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), we assessed QoL at baseline and at 8 weeks. Results: Mean baseline Q-LES-Q scores were 56%, representing moderate impairment in QoL. Group PE was associated with a 5-point increase in Q-LES-Q scores (where higher scores indicate better QoL). Examination of the questionnaire's subscales revealed that 2 domains (that is, physical functioning and general satisfaction) increased significantly following PE, with the remaining domains showing nonsignificant trends toward improved functioning. Multivariate analysis indicated that only one factor (having had a recent episode of depression) significantly predicted pre- and posttreatment Q-LES-Q scores. Conclusion: Patients with BD continue to show impaired QoL even when clinically euthymic. Although preliminary, our results show that group PE is associated with improved QoL in this population, both in terms of general satisfaction and in relation to levels of physical functioning. The use of PE as an adjunct to pharmacotherapy in BD should be further studied with particular emphasis on characterizing the effects of treatment intervention on perceived QoL.

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Cathartic Effect of Suicide Attempts Not Limited to Depression

Crisis ◽

10.1027//0227-5910.24.2.73 ◽

2003 ◽

Vol 24 (2) ◽

pp. 73-78 ◽

Cited By ~ 21

Author(s):

Yves Sarfati ◽

Blandine Bouchaud ◽

Marie-Christine Hardy-Baylé

Keyword(s):

Quality Of Life ◽

Depressive Symptoms ◽

Personality Traits ◽

Rating Scales ◽

Suicide Attempts ◽

World Health ◽

Life Questionnaire ◽

Short Term

Summary: The cathartic effect of suicide is traditionally defined as the existence of a rapid, significant, and spontaneous decrease in the depressive symptoms of suicide attempters after the act. This study was designed to investigate short-term variations, following a suicide attempt by self-poisoning, of a number of other variables identified as suicidal risk factors: hopelessness, impulsivity, personality traits, and quality of life. Patients hospitalized less than 24 hours after a deliberate (moderate) overdose were presented with the Montgomery-Asberg Depression and Impulsivity Rating Scales, Hopelessness scale, MMPI and World Health Organization's Quality of Life questionnaire (abbreviated versions). They were also asked to complete the same scales and questionnaires 8 days after discharge. The study involved 39 patients, the average interval between initial and follow-up assessment being 13.5 days. All the scores improved significantly, with the exception of quality of life and three out of the eight personality traits. This finding emphasizes the fact that improvement is not limited to depressive symptoms and enables us to identify the relative importance of each studied variable as a risk factor for attempted suicide. The limitations of the study are discussed as well as in particular the nongeneralizability of the sample and setting.

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