Comparative study of psychiatric comorbidity differences in patients with ADHD and cocaine substance use disorders and patients ADHD and cannabis use disorders

2017 ◽  
Vol 41 (S1) ◽  
pp. S477-S477
Author(s):  
N. Martínez-Luna ◽  
L. Rodriguez-Cintas ◽  
C. Daigre ◽  
L. Grau-Lopez ◽  
R.F. Palma-Alvarez ◽  
...  
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Drug Users ◽  
Psychiatric Comorbidity ◽  
Psychotic Disorders ◽  
Neuronal Damage ◽  
Total Sample ◽  
Cocaine Users ◽  
The Difference ◽  
Competing Interest

Substance Use Disorders (SUD) and Attention Deficit Hyperactive Disorder (ADHD) are frequent conditions in out drug treatment centers. There are evidences about the high prevalence of ADHD in SUD patients (20%) compared with just ADHD in general population (1–7.3%). Both disorders and psychiatric comorbidity are important in the diagnosis proceeding. The objective of this study is search the difference in psychiatric comorbidity conditions between patients with ADHD and Cocaine SUD and ADHD and Cannabis SUD. ADHD was present in 158 patients of a total sample in which 46,8% used cocaine, 17.1% cannabis and 36.1% used both. Mood disorders were 26.8% in cocaine users, 21.7% in cannabis and 18.9% in both. Anxiety disorders were 20.3% in cocaine users, 37.5 in cannabis and 13% in both users. Primary psychotic disorders were 2.9% in cocaine users, none in cannabis and 11,1% in both drug users. Personality disorders by cluster were, Cluster A: 11.3% in cocaine group, 36% in cannabis group and 24.5 in cannabis and cocaine group. Cluster B: 33.8% in cocaine group, 44% in cannabis group and 51.9% in cannabis and cocaine group. Cluster C: 9.9% in cocaine group, 28% in cannabis group and 19.2% in cannabis and cocaine group. There could be common pathways of neuronal damage related to psychiatric comorbidity depending of used drug, the differences in comorbidity found in this study could explain a little part of it. It is important to manage SUD-ADHD and other psychiatric comorbidity in order to improve the outcomes of these patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Elevated neutrophil lymphocyte ratio in patients with substance use disorders

2017 ◽  
Vol 41 (S1) ◽  
pp. S872-S873 ◽  
Author(s):  
N. Ozkan ◽  
M.B. Sonmez ◽  
P. Tas Durmus ◽  
Y. Gorgulu ◽  
R. Kose Cınar ◽  
...  
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Synthetic Cannabinoid ◽  
Healthy Controls ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Addiction Severity ◽  
Reactive Protein ◽  
The Difference ◽  
Competing Interest

IntroductionDisturbances in inflammatory processes may play a role in the pathophysiology of psychiatric disorders. The neutrophil lymphocyte ratio (NLR) and C-reactive protein (CRP) are indicators of the systemic inflammatory response.ObjectivesThe current study was prepared based on the assumption that dysregulated immune function and elevated inflammation markers may be seen in substance use disorders.AimsOur aim was to investigate whether NLR and CRP are higher in patients diagnosed with substance use disorders than in healthy subjects.MethodsThe participants in the study included 115 male inpatients diagnosed with alcohol (n = 41), heroin (n = 46), or synthetic cannabinoid (n = 28) dependence according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV-TR), and 32 healthy male volunteers. We used NLR and CRP as measures of systemic inflammation. Blood samples were taken on the next morning of admission for detoxification. Addiction severity was assessed using the Addiction Profile Index (API).ResultsThe difference between the groups with respect to NLR was statistically significant (P = 0.014). Patients diagnosed with alcohol, heroin or synthetic cannabinoid dependence had similar NLR. Patients with alcohol or synthetic cannabinoid dependence had significantly higher NLR than healthy controls (P = 0.001 and P = 0.029, respectively). Patients with heroin dependence trended towards statistically significantly higher NLR compared to healthy controls (P = 0.067). CRP levels did not differ significantly between the patient and control groups. NLR and CRP were not significantly correlated with API scores.ConclusionsOur findings suggest that NLR is elevated in patients with substance use disorders in comparison to healthy controls.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Plasma Concentrations of BDNF and IGF-1 in Abstinent Cocaine Users with High Prevalence of Substance Use Disorders: Relationship to Psychiatric Comorbidity

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0118610 ◽  
Author(s):  
María Pedraz ◽  
Ana Isabel Martín-Velasco ◽  
Nuria García-Marchena ◽  
Pedro Araos ◽  
Antonia Serrano ◽  
...  
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Psychiatric Comorbidity ◽  
Plasma Concentrations ◽  
High Prevalence ◽  
Cocaine Users

Psychotic Disorders and Substance Use Disorders

2020 ◽  
pp. 1341-1355
Author(s):  
Daniele Carretta ◽  
Francesco Bartoli ◽  
Giuseppe Carrà
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Psychotic Disorders

Effectiveness of long-acting injectables and clozapine in a real-world setting during the early-stages of psychotic illness

2016 ◽  
Vol 33 (S1) ◽  
pp. S105-S105
Author(s):  
E.G. Ostinelli ◽  
E. Guanella ◽  
S. Cavallotti ◽  
C. Casetta ◽  
A. D’Agostino
Keyword(s):  
Psychotic Disorders ◽  
Pharmacological Intervention ◽  
Psychotic Illness ◽  
Treatment As Usual ◽  
Early Stages ◽  
Hospitalization Rates ◽  
Real World Setting ◽  
The Difference ◽  
Competing Interest ◽  
Long Acting

IntroductionIntervention in the early-stages of psychosis may be able to shape the clinical course; critical period (CP) is best represented by the first 5 years from first admission (FA).ObjectivesTo investigate the effectiveness of pharmacological intervention within and beyond the CP.Aims(1) To compare hospitalization rates of patients stabilized on treatment with LAIs and CLZ. (2) To determine whether treatment with LAIs and CLZ within CP can influence hospitalization rates.MethodsData were retrospectively collected from patients diagnosed with non-affective psychoses with FA between 2000 and 2014; 200 patients were then divided into three groups, according to stabilized treatment regimen during the final year of observation: treatment as usual (TAU), CLZ, LAIs. hospitalization duration (HSPD) and frequency (HSP) were calculated for each group.ResultsDespite a major severity before assignment to either CLZ or LAIs treatment, HSPD and HSP in both groups shifted below those observed for the TAU arm. Patients who began treatment with LAIs within the CP showed a highly significant decrease of both HSPD and HSP (respectively 17.4 ± 18 vs. 2.6 ± 8.2; Z = −2.856; P < 0.005 and 1.1 ± 0.8 vs. 0.2 ± 0.5; Z = −3.115; P < 0.005). No significant changes in hospitalization rates were observed for subjects who began treatment with LAIs after the CP.ConclusionsOur study confirms that treatment with either CLZ or LAIs significantly impacts the course of psychotic disorders. The data seem to suggest that LAIs and CLZ should be considered more effective than conventional oral antipsychotics in the early-stages of psychotic illness. The difference among treatments tends to wane beyond the CP, especially for LAIs.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Psychotic Disorders and Substance Use Disorders

2014 ◽  
pp. 2013-2034
Author(s):  
Daniele Carretta ◽  
Massimo Clerici ◽  
Francesco Bartoli ◽  
Giuseppe Carrà
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Psychotic Disorders

scholarly journals A Comparative Study of Psychiatric Comorbidity in Male Adolescents with Substance use Disorders and Male Adolescents with Conduct Disorder

2000 ◽  
Vol 23 (1) ◽  
pp. 41-46
Author(s):  
Anrn Selvanayagam, D ◽  
Balm Ponmani Stephen ◽  
Senthil Kumar M ◽  
Suresh Kumar M ◽  
Raj Kumar R ◽  
...  
Keyword(s):  
Substance Use ◽  
Conduct Disorder ◽  
Comparative Study ◽  
Substance Use Disorders ◽  
Psychiatric Comorbidity ◽  
Male Adolescents

scholarly journals Patients with stroke and psychiatric comorbidities have lower carotid revascularization rates

Neurology ◽  
2019 ◽  
Vol 92 (22) ◽  
pp. e2514-e2521 ◽  
Author(s):  
Diana M. Bongiorno ◽  
Gail L. Daumit ◽  
Rebecca F. Gottesman ◽  
Roland Faigle
Keyword(s):  
Mental Illness ◽  
Substance Use ◽  
Carotid Stenosis ◽  
Substance Use Disorders ◽  
Psychiatric Comorbidity ◽  
Cross Sectional ◽  
Psychiatric Comorbidities ◽  
Lower Odds ◽  
Carotid Revascularization ◽  
Psychiatric Conditions

ObjectiveWe investigated whether mental illness is associated with lower rates of carotid endarterectomy (CEA)/carotid artery stenting (CAS) after stroke due to carotid stenosis.MethodsIn this retrospective cross-sectional study, ischemic stroke cases due to carotid stenosis were identified in the 2007–2014 Nationwide (National) Inpatient Sample. Psychiatric conditions were identified by secondary ICD-9-CM diagnosis codes for schizophrenia/psychoses, bipolar disorder, depression, anxiety, or substance use disorders. Using logistic regression, we tested the association between psychiatric conditions and CEA/CAS, controlling for demographic, clinical, and hospital factors.ResultsAmong 37,474 included stroke cases, 6,922 (18.5%) had a psychiatric comorbidity. The presence of any psychiatric condition was associated with lower odds of CEA/CAS (adjusted odds ratio [OR] 0.84, 95% confidence interval [CI] 0.78–0.90). Schizophrenia/psychoses (OR 0.72, 95% CI 0.55–0.93), depression (OR 0.83, 95% CI 0.75–0.91), and substance use disorders (OR 0.73, 95% CI 0.65–0.83) were each associated with lower odds of CEA/CAS. The association of mental illness and CEA/CAS was dose-dependent: compared to patients without mental illness, patients with multiple psychiatric comorbidities (OR 0.74, 95% CI 0.62–0.87) had lower odds of CEA/CAS than those with only one psychiatric comorbidity (OR 0.86, 95% CI 0.79–0.92; p value for trend <0.001).ConclusionThe odds of carotid revascularization after stroke is lower in patients with mental illness, particularly those with schizophrenia/psychoses, depression, substance use disorders, and multiple psychiatric diagnoses.

Sign in / Sign up

Export Citation Format

Share Document