How are personality traits and physical activity involved in colorectal carcinogenesis? A cross-sectional study on patients undergoing colonoscopy

IntroductionInflammatory state of the large bowel is a key factor for the development of colorectal cancer (CRC). It has multifactorial aetiology, including psychological determinants. Physical activity may have a protective function against CRC via anti-inflammatory properties; on the contrary, personality traits correlate with an unhealthy and dangerous lifestyle.ObjectiveTo measure the association between personality traits, lifestyle and colonoscopy outcome.MethodsCross sectional study. Patients undergoing colonoscopy aged 40 or more, with a negative history for cancer or inflammatory bowel disease, were enrolled. Data collected: colonoscopy outcome, smoke, alcohol, physical activity, presence/absence of Metabolic Syndrome, personality traits assessed by the Temperament & Character Inventory (TCI).ResultsIn a sample of 53 subjects (females = 24, 45.3%), the mean age was 60.66 ± 9.08. At least one adenoma was found to 23 patients (43.3%). Twenty patients were smokers (37.74%), 36 (67.92%) drank alcohol at least weekly; approximately 60% reported regular physical activity. At the multivariate regression, the outcome was associated to: TCI Self Transcendence domain (ST) (OR = 1.36, P = 0.04) and physical activity (OR = 0.14, P = 0.03).ConclusionPeople with ST's characteristic personality traits and sedentary life style are more likely to have precancerous colorectal lesions. This confirms the protective role of physical activity, and suggests to further explore the role of personality in cancerogenesis.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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How Are Personality Traits and Physical Activity Involved in Colorectal Carcinogenesis? a Cross-sectional Study on Patients Undergoing Colonoscopy

10.26226/morressier.588f064ed462b8028d892461 ◽

2017 ◽

Author(s):

Giulia Rioli

Keyword(s):

Physical Activity ◽

Personality Traits ◽

Cross Sectional Study ◽

Colorectal Carcinogenesis ◽

Sectional Study ◽

Cross Sectional

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Personality traits and physical activity may be involved in colorectal carcinogenesis: preliminary data from a cross-sectional study on patients undergoing colonoscopy

Minerva Psichiatrica ◽

10.23736/s0391-1772.19.02013-2 ◽

2019 ◽

Vol 60 (2) ◽

Author(s):

Mattia Marchi ◽

Giorgio Mattei ◽

Stefano Mancini ◽

Luca Roncucci ◽

Gian M. Galeazzi ◽

...

Keyword(s):

Physical Activity ◽

Personality Traits ◽

Preliminary Data ◽

Cross Sectional Study ◽

Colorectal Carcinogenesis ◽

Sectional Study ◽

Cross Sectional

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The role of physical activity and diet on bone mineral indices in young men: a cross-sectional study

Journal of the International Society of Sports Nutrition ◽

10.1186/1550-2783-10-43 ◽

2013 ◽

Vol 10 (1) ◽

Cited By ~ 3

Author(s):

Selma C Liberato ◽

Josefina Bressan ◽

Andrew P Hills

Keyword(s):

Physical Activity ◽

Bone Mineral ◽

Young Men ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study

Acta Endocrinologica ◽

10.1530/eje-20-0795 ◽

2021 ◽

Vol 184 (3) ◽

pp. 423-429

Author(s):

M Albertelli ◽

E Nazzari ◽

A Dotto ◽

L F Grasso ◽

S Sciallero ◽

...

Keyword(s):

Acetylsalicylic Acid ◽

Disease Duration ◽

Colonic Polyps ◽

Cross Sectional Study ◽

Protective Role ◽

Diabetic Patients ◽

Sectional Study ◽

Cross Sectional ◽

Acid Intake

Context Colonic polyps occur in 30–40% of acromegalic patients, increasing the risk of colon carcinoma. Although debated, there is emerging evidence that metformin may play a protective role in diabetic and non-diabetic patients with colonic polyps and its use in chemoprevention is currently explored. Objective Evaluate the prevalence of colonic polyps in acromegalic patients treated or not with metformin and explore its possible protective role. Design Exploratory cross-sectional study in two tertiary Italian referral centres. Met hods: Out of 153 acromegalic patients, we selected 58 patients (36–82 years; f: 33) who had at least one colonoscopy performed within the first 2 years of diagnosis. Presence of colonic polyps/cancer and related risk factors, current metformin and acetylsalicylic acid intake, disease duration, therapies for acromegaly, hormonal and metabolic parameters were assessed. Results An overall prevalence of 36% polyps was found. Based on the presence of polyps, we identified two groups, comparable for age, BMI, disease duration, glucose, insulin, HOMA-IR, HbA1c, GH and IGF-I levels. Of the patients with polyps (including three adenocarcinomas) only 24% were treated with metformin vs 57% of patients without polyps. Multivariate analysis confirmed a significant negative association between colonic polyps and metformin intake (OR: 0.22, 95% CI: 0.06-0.77, P = 0.01), whereas no significant association was found between polyps and age (P = 0.10), overweight/obesity (P = 0.54), smoking (P = 0.15), acetylsalicylic acid intake (P = 0.99), disease duration (P = 0.96), somatostatin analogues treatment (P = 0.70). Conclusions These findings, though deriving from an exploratory study, could suggest a protective role of metformin on the development of colonic polyps in acromegaly, and need to be confirmed in an extended study population.

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