Skeletal muscle RBM3 expression is associated with extended lifespan in Ames Dwarf and calorie restricted mice

2021 ◽  
Vol 146 ◽  
pp. 111214
Author(s):  
Zachary R. Hettinger ◽  
Amy L. Confides ◽  
Peter W. Vanderklish ◽  
Silvana Sidhom ◽  
Michal M. Masternak ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Ames Dwarf ◽  
Extended Lifespan ◽  
Rbm3 Expression

The effect of calorie restriction on adiponectin and mir-146 in skeletal muscle and adipose tissue of Ames dwarf mice

2017 ◽  
Vol 94 ◽  
pp. 114 ◽  
Author(s):  
Denise S. Wiesenborn ◽  
Augusto Schneider ◽  
Berta Victoria ◽  
Lina Spinel ◽  
Kari Martyniak ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Calorie Restriction ◽  
Ames Dwarf Mice ◽  
Ames Dwarf ◽  
Dwarf Mice

Effects of long-term caloric restriction on glucose homeostasis and on the first steps of the insulin signaling system in skeletal muscle of normal and Ames dwarf (Prop1df/Prop1df) mice

2005 ◽  
Vol 40 (1-2) ◽  
pp. 27-35 ◽  
Author(s):  
Danila Paula Argentino ◽  
Fernando Pablo Dominici ◽  
Marina Cecilia Muñoz ◽  
Khalid Al-Regaiey ◽  
Andrzej Bartke ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Caloric Restriction ◽  
Glucose Homeostasis ◽  
Insulin Signaling ◽  
Signaling System ◽  
Ames Dwarf

Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice

2014 ◽  
Vol 58 ◽  
pp. 146-153 ◽  
Author(s):  
Kazuhide Takahashi ◽  
Yoshihiro Noda ◽  
Ikuroh Ohsawa ◽  
Takuji Shirasawa ◽  
Mayumi Takahashi
Keyword(s):  
Skeletal Muscle ◽  
Body Size ◽  
Transgenic Mice ◽  
Muscle Mass ◽  
Mitochondrial Function ◽  
Skeletal Muscle Mass ◽  
Reduced Body ◽  
Extended Lifespan

Ames dwarf (Prop1df/Prop1df) mice display increased sensitivity of the major GH-signaling pathways in liver and skeletal muscle

2010 ◽  
Vol 20 (2) ◽  
pp. 118-126 ◽  
Author(s):  
Johanna G. Miquet ◽  
Marina C. Muñoz ◽  
Jorge F. Giani ◽  
Lorena González ◽  
Fernando P. Dominici ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Signaling Pathways ◽  
Ames Dwarf ◽  
Increased Sensitivity

scholarly journals Enhanced survival of skeletal muscle myoblasts in response to overexpression of cold shock protein RBM3

2011 ◽  
Vol 301 (2) ◽  
pp. C392-C402 ◽  
Author(s):  
Amy L. Ferry ◽  
Peter W. Vanderklish ◽  
Esther E. Dupont-Versteegden
Keyword(s):  
Skeletal Muscle ◽  
Cell Death ◽  
Cell Viability ◽  
Muscle Mass ◽  
Muscle Cell ◽  
Cold Shock ◽  
Rna Binding ◽  
Cell Permeability ◽  
Cold Shock Protein ◽  
Rbm3 Expression

Cold-inducible RNA-binding protein (RBM3) is suggested to be involved in the regulation of skeletal muscle mass. Cell death pathways are implicated in the loss of muscle mass and therefore the role of RBM3 in muscle apoptosis in C2C12 myoblasts was investigated in this study. RBM3 overexpression was induced by either cold shock (32°C exposure for 6 h) or transient transfection with a myc-tagged RBM3 expression vector. Cell death was induced by H2O2 (1,000 μM) or staurosporine (StSp, 5 μM), and it was shown that cold shock and RBM3 transfection were associated with attenuation of morphological changes and an increase in cell viability compared with normal temperature or empty vector, respectively. No changes in proliferation were observed with either cold shock or RBM3 transfection. DNA fragmentation was not increased in response to H2O2, and a cell permeability assay indicated that cell death in response to H2O2 is more similar to necrosis than apoptosis. RBM3 overexpression reduced apoptosis and the collapse of the membrane potential in response to StSp. Moreover, the increase in caspase-3, -8, and -9 activities in response to StSp was returned to control levels with RBM3 overexpression. These results indicate that increased RBM3 expression decreases muscle cell necrosis as well as apoptosis and therefore RBM3 could potentially serve as an intervention for the loss of muscle cell viability during muscle atrophy and muscle diseases.

scholarly journals The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice

Aging ◽  
2014 ◽  
Vol 6 (10) ◽  
pp. 900-912 ◽  
Author(s):  
Denise S. Wiesenborn ◽  
Vinal Menon ◽  
Xu Zhi ◽  
Andrew Do ◽  
Adam Gesing ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Calorie Restriction ◽  
Insulin Signaling ◽  
Ames Dwarf Mice ◽  
Ames Dwarf ◽  
Dwarf Mice

Endotoxin Alteration of the Mucopolysaccharide Blood Vessel Coating in Rats

1974 ◽  
Vol 32 ◽  
pp. 148-149
Author(s):  
D. E. Philpott ◽  
A. Takahashi
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Salivary Gland ◽  
Carotid Artery ◽  
Basement Membrane ◽  
Coronary Vessels ◽  
Ruthenium Red ◽  
E Coli ◽  
Old Rats ◽  
The Brain

Two month, eight month and two year old rats were treated with 10 or 20 mg/kg of E. Coli endotoxin I. P. The eight month old rats proved most resistant to the endotoxin. During fixation the aorta, carotid artery, basil arartery of the brain, coronary vessels of the heart, inner surfaces of the heart chambers, heart and skeletal muscle, lung, liver, kidney, spleen, brain, retina, trachae, intestine, salivary gland, adrenal gland and gingiva were treated with ruthenium red or alcian blue to preserve the mucopolysaccharide (MPS) coating. Five, 8 and 24 hrs of endotoxin treatment produced increasingly marked capillary damage, disappearance of the MPS coating, edema, destruction of endothelial cells and damage to the basement membrane in the liver, kidney and lung.

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