Age-related changes in swallowing muscle intramuscular adipose tissue deposition and related factors

2021 ◽  
pp. 111505
Author(s):  
Kohei Yamaguchi ◽  
Kazuharu Nakagawa ◽  
Kanako Yoshimi ◽  
Chantaramanee Ariya ◽  
Ayako Nakane ◽  
...  
2011 ◽  
pp. P2-351-P2-351
Author(s):  
Lucila Sackmann Sala ◽  
Clare B Vesel ◽  
Ellen R Lubbers ◽  
Rachel D Munn ◽  
Katie M Troike ◽  
...  

2020 ◽  
Author(s):  
Emily L. Goldberg ◽  
Irina Shchukina ◽  
Yun-Hee Youm ◽  
Christina D. Camell ◽  
Tamara Dlugos ◽  
...  

AbstractAging impairs the integrated immunometabolic responses which have evolved to maintain core body temperature in homeotherms to survive cold-stress, infections, and dietary restriction. Adipose tissue inflammation regulates the thermogenic stress response but how adipose tissue-resident cells instigate thermogenic failure in aged are unknown. Here, we define alterations in the adipose-resident immune system and identify that type 2 innate lymphoid cells (ILC2) are lost in aging. Restoration of ILC2 numbers in aged mice to levels seen in adults through IL-33 supplementation failed to rescue old mice from metabolic impairment and cold-induced lethality. Transcriptomic analyses revealed intrinsic defects in aged ILC2, and adoptive transfer of adult ILC2 are sufficient to protect old mice against cold. Thus, the functional defects in adipose ILC2 during aging drive thermogenic failure.One Sentence SummaryAge-related changes in adipose tissue drive reprogramming of ILC2 that leads to impaired cold tolerance


2002 ◽  
Vol 34 (11/12) ◽  
pp. 716-720 ◽  
Author(s):  
F. Adams ◽  
P. Wiedmer ◽  
K. Gorzelniak ◽  
S. Engeli ◽  
S. Klaus ◽  
...  

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