Iron-loaded transferrin potentiates erythropoietin effects on erythroblast proliferation and survival: A novel role through transferrin receptors

2021 ◽  
Author(s):  
Guillemette Fouquet ◽  
Umnuaychoke Thongsa-ad ◽  
Carine Lefevre ◽  
Alice Rousseau ◽  
Nopmullee Tanhuad ◽  
...  
Keyword(s):  
Transferrin Receptors

scholarly journals Increase in surface expression of transferrin receptors on cultured hepatocytes of adult rats in response to iron deficiency.

1988 ◽  
Vol 263 (29) ◽  
pp. 14753-14756
Author(s):  
U Muller-Eberhard ◽  
H H Liem ◽  
J A Grasso ◽  
S Giffhorn-Katz ◽  
M G DeFalco ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Surface Expression ◽  
Transferrin Receptors ◽  
Cultured Hepatocytes ◽  
Adult Rats

scholarly journals Transcriptional regulation by iron of the gene for the transferrin receptor.

1986 ◽  
Vol 6 (1) ◽  
pp. 236-240 ◽  
Author(s):  
K Rao ◽  
J B Harford ◽  
T Rouault ◽  
A McClelland ◽  
F H Ruddle ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
K562 Cells ◽  
Iron Chelator ◽  
Transcriptional Level ◽  
Transferrin Receptors ◽  
Intracellular Iron ◽  
Human Transferrin Receptor ◽  
Diferric Transferrin ◽  
Permeable Iron

Treatment of K562 cells with desferrioxamine, a permeable iron chelator, led to an increase in the number of transferrin receptors. Increasing intracellular iron levels by treatment of cells with either human diferric transferrin or hemin lowered the level of the transferrin receptors. By using a cDNA clone of the human transferrin receptor, we showed that the changes in the levels of the receptor by iron were accompanied by alterations in the levels of the mRNA for the receptor. The rapidity of these changes indicated that the mRNA had a very short half-life. By using an in vitro transcriptional assay with isolated nuclei, we obtained evidence that this regulation occurred at the transcriptional level.

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