Serum Ferritin and Soluble Transferrin Receptors in Type II Diabetic Patients: Correlation with TNF-αas a Marker of Inflammation

Background: Diabetes is one of the most common disease which is observed in every household of Indian population. The longevity of the diabetic patients is dependent upon the frequency of complication and comorbidity that they encounter. Serum iron and ferritin, both being the aggravators to the oxidative stress accelerating the development of complications, gives us the reason to venture into the territory exploring the possibility of monitoring the body iron stores and taking prevent measures to control such complication. The current study was designed with an aim to knot the relationship between body iron stores and glycemic control in patients of type-II diabetes mellitus. Aims and Objectives: To measure the levels of serum ferritin, serum Iron, transferrin saturation and HbA1C and finding out the relationship between body iron stores and glycemic control in patients of Type-II Diabetes Mellitus. Materials and Methods: A total of 50 diagnosed cases of type II DM and 50 healthy controls between the age group of 35-65 years were taken following inclusion and exclusion criteria. Body iron stores were assessed by measuring serum ferritin, Serum iron and Transferrin saturation and Glycemic control was assessed by measuring levels of HbA1C. Results: A significant increase in serum ferritin, serum iron and Transferrin saturation (P<0.001) was noted in diabetic patients as compared to controls. There was a positive correlation between serum iron and transferring saturation in the diabetic patients. Conclusion: The co-morbidities and complications in the Diabetic population can be prevented by monitoring Body iron stores as they can significantly contribute to the oxidative stress leading to the complication and decreased life expectancy. Early detection in the abnormality in the body iron store can help us in employing proper measures for a better management of Type-II diabetic patients and thereby improving their survival.

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ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i8.456 ◽

2019 ◽

Vol 3 (8) ◽

Author(s):

Shah Namrata Vinubhai ◽

Pardeep Agarwal ◽

Bushra Fiza ◽

Ramkishan Jat

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Sugar ◽

Serum Ferritin ◽

Inflammatory Marker ◽

Control Group ◽

Diabetic Patients ◽

Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

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Thyroid hormones and TRH-evoked TSH-secretion in longstanding type-II diabetic patients before and after insulin treatment

Acta Endocrinologica ◽

10.1530/acta.0.109s047-a ◽

1985 ◽

Vol 110 (1_Suppla) ◽

pp. S47-S48

Author(s):

CH. SCHNACK ◽

G. SCHERNTHANER ◽

H. WEGHAUPT

Keyword(s):

Thyroid Hormones ◽

Insulin Treatment ◽

Diabetic Patients ◽

Type Ii ◽

Before And After ◽

Tsh Secretion

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Elevated plasma concentrations of beta-cell tropin (ACTH22-39) in diet-treated type II diabetic patients

Diabetes ◽

10.2337/diabetes.41.9.1160 ◽

1992 ◽

Vol 41 (9) ◽

pp. 1160-1164 ◽

Cited By ~ 1

Author(s):

J. C. Levy ◽

J. L. Morton ◽

M. Davenport ◽

A. Beloff-Chain ◽

R. C. Turner

Keyword(s):

Beta Cell ◽

Plasma Concentrations ◽

Diabetic Patients ◽

Type Ii ◽

Elevated Plasma

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Postreceptor effects of sulfonylurea on skeletal muscle glycogen synthase activity in type II diabetic patients

Diabetes ◽

10.2337/diabetes.38.11.1343 ◽

1989 ◽

Vol 38 (11) ◽

pp. 1343-1350 ◽

Cited By ~ 28

Author(s):

J. F. Bak ◽

O. Schmitz ◽

N. S. Sorensen ◽

O. Pedersen

Keyword(s):

Skeletal Muscle ◽

Muscle Glycogen ◽

Glycogen Synthase ◽

Diabetic Patients ◽

Type Ii ◽

Skeletal Muscle Glycogen ◽

Glycogen Synthase Activity

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Renal effects of nicardipine, a calcium entry blocker, in hypertensive type II diabetic patients with nephropathy

Diabetes ◽

10.2337/diabetes.35.11.1206 ◽

1986 ◽

Vol 35 (11) ◽

pp. 1206-1214 ◽

Cited By ~ 8

Author(s):

T. Baba ◽

T. Ishizaki ◽

Y. Ido ◽

K. Aoyagi ◽

S. Murabayashi ◽

...

Keyword(s):

Calcium Entry ◽

Diabetic Patients ◽

Calcium Entry Blocker ◽

Type Ii ◽

Renal Effects ◽

Entry Blocker

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Relationship between uric acid and creatinine in pre-diabetic and diabetic patients: Vidarbha region of Maharashtra

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i3.2479 ◽

2020 ◽

Vol 11 (3) ◽

pp. 3412-3417

Author(s):

Ranjit S. Ambad ◽

Rakesh Kumar Jha ◽

Lata Kanyal Butola ◽

Nandkishor Bankar ◽

Brij Raj Singh ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Type Ii Diabetes ◽

Fasting Blood Glucose ◽

General Medicine ◽

Control Group ◽

Diabetic Patients ◽

Type Ii ◽

Develop Type ◽

Low Levels

Prediabetes is a glucose homeostasis condition characterized by decreased absorption to glucose or reduced fasting glucose. Both of these are reversible stages of intermediate hyperglycaemia providing an increased type II DM risk. Pre-diabetes can therefore be viewed as a significant reversible stage which could lead to type II DM, and early detection of prediabetes may contribute to type II DM prevention. Prediabetes patients are at high risk for potential type II diabetes, and 70 percent of them appear to develop Type II diabetes within 10 years. The present study includes total 200 subjects that include 100 Prediabetic patients, 50 T2DM patients and 50 healthy individual. Blood samples were collected from the subjects were obtained for FBS, PPBS, Uric acid and Creatinine estimation, from OPD and General Medicine Wards. Present study showed low levels of Serum Uric Acid in prediabetic and T2DM patients were decreased as compared to control group, while the level of creatinine in prediabetic and diabetic were elevated as compared to control group, were not statically significant. Serum Uric Acid was high in control group and low in prediabetic and diabetic patients. Serum creatinine was declined in control group and increased in prediabetic and diabetic patients with increasing Fasting blood glucose level.

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