Rno_circRNA_016194 might be involved in the testicular injury induced by long-term formaldehyde exposure via rno-miR-449a-5p mediated Atg4b activation

2021 ◽  
pp. 112409
Author(s):  
Pan Ge ◽  
Xiang Zhang ◽  
Yan-qi Yang ◽  
Mo-qi Lv ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Formaldehyde Exposure ◽  
Testicular Injury

scholarly journals Effect of formaldehyde exposure on bacterial communities in simulating indoor environments

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jianguo Guo ◽  
Yi Xiong ◽  
Taisheng Kang ◽  
Hua Zhu ◽  
Qiwen Yang ◽  
...  
Keyword(s):  
Bacterial Community ◽  
Human Health ◽  
Bacterial Communities ◽  
Shannon Index ◽  
Chemical Degradation ◽  
Indoor Environments ◽  
Operational Taxonomic Units ◽  
Formaldehyde Exposure ◽  
Recommended Level

AbstractIndoor formaldehyde (CH2O) exceeding the recommended level is a severe threat to human health. Few studies have investigated its effect on indoor surface bacterial communities, affecting habitants' health. This study used 20-L glass containers to mimic the indoor environment with bacterial inputs from human oral respiration. The behavior of bacterial communities responding to CH2O varied among the different CH2O levels. The bacterial community structure significantly changed over time in the 0.054 mg·m−3 CH2O group, which varied from the 0.1 mg·m−3 and 0.25 mg·m−3 CH2O groups. The Chao1 and Shannon index significantly increased in the 0.054 mg·m−3 CH2O group at 6 week, while they remained unchanged in the 0.25 mg·m−3 CH2O group. At 12 week, the Chao1 significantly increased in the 0.25 mg·m−3 CH2O group, while it remained unchanged in the 0.054 mg·m−3 CH2O group. Only a few Operational Taxonomic Units (OTUs) significantly correlated with the CH2O concentration. CH2O-induced OTUs mainly belong to the Proteobacteria and Firmicutes. Furthermore, bacterial communities formed at 6 or 12 weeks differed significantly among different CH2O levels. Functional analysis of bacterial communities showed that inferred genes related to chemical degradation and diseases were the highest in the 0.25 mg·m−3 CH2O group at 12 weeks. The development of nematodes fed with bacteria collected at 12 weeks was applied to evaluate the bacterial community's hazards. This showed significantly impaired growth in the 0.1 mg·m−3 and 0.25 mg·m−3 CH2O groups. These findings confirmed that CH2O concentration and exposure time could affect the indoor bacterial community and formed bacterial communities with a possibly more significant hazard to human health after long-term exposure to high CH2O levels.

Effects of low-dose, long-term formaldehyde exposure on the structure and functions of the ovary in rats

2012 ◽  
Vol 29 (7) ◽  
pp. 609-615 ◽  
Author(s):  
Hai-xu Wang ◽  
Xiao-yan Wang ◽  
Dang-xia Zhou ◽  
Lie-rui Zheng ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Low Dose ◽  
Formaldehyde Exposure ◽  
Structure And Functions

scholarly journals GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Rongrong Xie ◽  
Linqi Chen ◽  
Haiying Wu ◽  
Ting Chen ◽  
Fengyun Wang ◽  
...  
Keyword(s):  
Gnrh Antagonist ◽  
Survival Rates ◽  
Adult Survivors ◽  
Male Rats ◽  
Adult Rats ◽  
Histological Changes ◽  
Before And After ◽  
Testicular Injury ◽  
To Receive

Background. Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods. The present study was aimed at longitudinally exploring whether the GnRHant could alleviate testicular damage induced by cyclophosphamide (CPA) in a rat model. Pubertal male rats were assigned to receive CPA with and without GnRHant. CPA was administrated at a single dose (100 mg/kg). GnRHant was started one hour prior to CPA injection and continued for four weeks (0.1 mg/kg, 3 times a week). Body and testes weights, testicular hormones, histological changes, and expression of androgen receptor (AR) in the testis were analyzed when rats matured into adulthood and completed a round of spermatogenesis. Results. Our results showed that body weight, histological injury, and AR expression in the testis were improved in the GnRHant + CPA group. However, testes weight and testicular hormones (anti-Müllerian hormone, inhibin B, and testosterone) did not markedly change. Conclusion. Our results indicate that the GnRHant administration before and after CPA in pubertal rats can protect long-term testicular injury induced by CPA via increased AR expression in the testes.

scholarly journals N6-Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N6-Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats

2017 ◽  
Vol 30 (8) ◽  
pp. 1572-1576 ◽  
Author(s):  
Bahar Edrissi ◽  
Koli Taghizadeh ◽  
Benjamin C. Moeller ◽  
Rui Yu ◽  
Dean Kracko ◽  
...  
Keyword(s):  
Low Dose ◽  
Nasal Epithelium ◽  
Formaldehyde Exposure ◽  
Dose Inhalation

Reduced allergic lung inflammation in rats following formaldehyde exposure: Long-term effects on multiple effector systems

Toxicology ◽  
2009 ◽  
Vol 256 (3) ◽  
pp. 157-163 ◽  
Author(s):  
Adriana Lino dos Santos Franco ◽  
Helori Vanni Domingos ◽  
Amilcar Sabino Damazo ◽  
Ana Cristina Breithaupt-Faloppa ◽  
Ana Paula Ligeiro de Oliveira ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Long Term Effects ◽  
Allergic Lung Inflammation ◽  
Formaldehyde Exposure

Effects of long-term low-dose formaldehyde exposure on global genomic hypomethylation in 16HBE cells

2011 ◽  
Vol 205 (3) ◽  
pp. 235-240 ◽  
Author(s):  
Qingcheng Liu ◽  
Linqing Yang ◽  
Chunmei Gong ◽  
Gonghua Tao ◽  
Haiyan Huang ◽  
...  
Keyword(s):  
Low Dose ◽  
Formaldehyde Exposure

scholarly journals Do not Dispose of Historic Fluid Collections: Evaluating Research Potential and Range of Use

2020 ◽  
Vol 34 (1) ◽  
pp. 157-169
Author(s):  
M. Herbin ◽  
M.D. Santin ◽  
R. Toro ◽  
K. Heuer ◽  
J. Cuisin ◽  
...  
Keyword(s):  
Analytical Methods ◽  
Future Research ◽  
Museum Professionals ◽  
Determining Factors ◽  
Formaldehyde Exposure ◽  
Fluid Collections ◽  
And Storage ◽  
Long Term Preservation ◽  
Over Time

Abstract The use of specific preservative solutions by museum professionals to maintain fluid-preserved specimens has fluctuated over the years with advances in chemistry. The determining factors for the original choice of solution closely correlate with the historical parameters and original usage of the collections. Consequently, for any given collection, changes and substitutions over time in the types of preservative fluids used have likely occurred. The present comparative analysis of the state of brain preservation, carried out at macroscopic, microscopic, and molecular levels, allowed us to evaluate the effect of the different treatments applied over time to fluid-preserved collections. Our results confirm that the duration of formaldehyde exposure of the tissues clearly has an effect on their long-term preservation. Despite the controversies associated with the quality or use of some historic fixatives, modern analytical methods such as medical imagery reveal the preservation quality in historic specimens and their potential for future research use. However, the choice of fixatives and storage fluids to preserve the specimens is of critical importance because today's choices will influence the use of the specimen for advanced analytical methods in the future.

scholarly journals Pelvic Fracture Associated with Intrapelvic Dislocation of Testis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Varun Chouhan ◽  
Manish ladhania ◽  
Kiran Chouhan
Keyword(s):  
Delayed Diagnosis ◽  
Pelvic Injury ◽  
Rare Injury ◽  
Excellent Outcome ◽  
Pelvic Injuries ◽  
Definitive Surgery ◽  
Testicular Injury ◽  
Testicular Dislocation ◽  
Adequate Communication

Introduction: Intrapelvic testicular dislocation is rare injury with the possibility of missed or delayed diagnosis. Timely diagnosis of intrapelvic testicular dislocation can prevent iatrogenic testicular injury during surgery and its long-term sequel. Case Report: A 30-year-old male after motorbike accident presented with a pelvic injury with intrapelvic dislocation of testis. Timely and appropriate diagnosis of injuries, specially intrapelvic dislocation of testis, required early orchidopexy and open reduction and internal fixation of the anterior column, leading to excellent outcome. Conclusion: In cases of polytrauma and pelvic injuries specially motorbike accidents, testicular dislocation should be ruled out before definitive surgery. Adequate communication and co-ordination between orthopedic surgeon, radiologist, and urologist can lead to excellent outcomes. Keywords: Testicular dislocation, ectopic testicular dislocation, intrapelvic dislocation of testis.

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis
Keyword(s):  
Mental Health ◽  
Mental Disease ◽  
Brain Disorders ◽  
Social Stressors ◽  
Labor Education ◽  
Mental Diseases ◽  
Long Term Follow Up ◽  
Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

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