scholarly journals Perivitelline space abnormalities in the oocyte cohort reduces implantation and pregnancy rates in intracytoplasmic sperm injection cycles

2018 ◽  
Vol 110 (4) ◽  
pp. e309
Author(s):  
E. Borges ◽  
B.F. Zanetti ◽  
D.P. Braga ◽  
A.S. Setti ◽  
R.C. Figueira ◽  
...  
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Pregnancy Rates ◽  
Perivitelline Space ◽  
Implantation And Pregnancy Rates

The impact of obesity on oocytes: evidence for lipotoxicity mechanisms

2012 ◽  
Vol 24 (1) ◽  
pp. 29 ◽  
Author(s):  
Linda L.-Y. Wu ◽  
Robert J. Norman ◽  
Rebecca L. Robker
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mitochondrial Dysfunction ◽  
Intracytoplasmic Sperm Injection ◽  
Oocyte Quality ◽  
Early Embryo ◽  
Pregnancy Rates ◽  
Clinical Literature ◽  
The Impact

Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality.

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