Effect of management (organic vs conventional) on volatile profiles of six plum cultivars (Prunus salicina Lindl.). A chemometric approach for varietal classification and determination of potential markers

2016 ◽  
Vol 199 ◽  
pp. 479-484 ◽  
Author(s):  
F.J. Cuevas ◽  
J.M. Moreno-Rojas ◽  
F. Arroyo ◽  
A. Daza ◽  
M.J. Ruiz-Moreno
Keyword(s):  
Prunus Salicina ◽  
Varietal Classification ◽  
Volatile Profiles ◽  
Chemometric Approach

scholarly journals Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism

2018 ◽  
Vol 48 ◽  
pp. 134-140 ◽  
Author(s):  
Aleksandar Stojsavljević ◽  
Jelena Trifković ◽  
Zorica Rasić-Milutinović ◽  
Dragana Jovanović ◽  
Gradimir Bogdanović ◽  
...  
Keyword(s):  
Trace Elements ◽  
Icp Ms ◽  
Essential Trace Elements ◽  
Chemometric Approach

scholarly journals STABILITY-INDICATING METHOD FOR DETERMINATION OF TIZANIDINE HYDROCHLORIDE IN PHARMACEUTICAL LC-CAD METHOD USING CHEMOMETRIC APPROACH

2017 ◽  
Vol 1 (1) ◽  
pp. 61-66
Author(s):  
Mariana Brandalise ◽  
Pamela Cristina Lukasewicz Ferreira ◽  
Andrea Garcia Pereira ◽  
Leonardo Meneghini ◽  
Pedro Eduardo Fröehlich ◽  
...  
Keyword(s):  
Ammonium Acetate ◽  
Forced Degradation ◽  
Simple Method ◽  
Stability Indicating Method ◽  
Charged Aerosol ◽  
Charged Aerosol Detector ◽  
Chemometric Approach ◽  
Tablet Dosage ◽  
Drug Reference

A new LC method for tizanidine hydrochloride in tablet dosage form using a charged aerosol detector (CAD) is described. The influence of various parameters on chromatographic system was investigated by factorial designs and Derringer's desirability. Chromatographic conditions were: mobile phase constituted of acetonitrile and ammonium acetate buffer 17 mM (60:40; v/v), column oven at 39 °C and flow rate 0.8 mL.min-1 performed in on Acclaim Trinity P1 column UV at 230 nm. Thus, it was possible to validate a simple method to assay the tizanidine and its counter-ion in three formulations (drug reference, generic and manipulated). Method showed specificity when challenged by forced degradation and excipients. Finally, the method was compared with USP monograph method demonstrating equivalence in assay evaluation.

scholarly journals Determination of Carbamazepine and Its Impurities Iminostilbene and Iminodibenzyl in Solid Dosage Form by Column High-Performance Liquid Chromatography

2010 ◽  
Vol 93 (4) ◽  
pp. 1059-1068 ◽  
Author(s):  
Predrag Lj Džodić ◽  
Ljiljana J ivanovi ◽  
Ana D Proti ◽  
Mira L Zeevi ◽  
Biljana M Joci
Keyword(s):  
Mobile Phase ◽  
High Performance ◽  
Dosage Form ◽  
Internal Standard ◽  
Hplc Method ◽  
Solid Dosage ◽  
Rp Hplc ◽  
Good Repeatability ◽  
Chemometric Approach

Abstract An accurate and precise RP-HPLC method was developed and validated for the determination of carbamazepine and its impurities iminostilbene and iminodibenzyl in a tablet formulation with fluphenazine as an internal standard. Buffermethanol (50 + 50, v/v) was used as the mobile phase. During validation, specificity, linearity, precision, accuracy, LOD, LOQ, and robustness of the method were tested. The method was proven to be specific against placebo interference. Linearity was evaluated over the concentration range of 100500, 0.050.25, and 0.10.5 g/mL, and the r values were 0.9994, 0.9997, and 0.9979 for carbamazepine, iminostilbene, and iminodibenzyl, respectively. Intraday precision of the method was good, and RSD was below 2 for all analytes. The accuracy of the method ranged from 100.69 to 102.10, 99.76 to 102.66, and 99.26 to 100.08 for carbamazepine, iminostilbene, and iminodibenzyl, respectively. LOD was 0.0125, 0.025, and 0.05 g/mL and LOQ was 0.05, 0.05, and 0.1 g/mL for carbamazepine, iminostilbene, and iminodibenzyl, respectively. Robustness of the method was proven by using a chemometric approach. The method was successfully applied to the analysis of commercially available carbamazepine tablets and showed good repeatability, with RSD below 2.

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