Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis

2008 ◽  
Vol 44 (12) ◽  
pp. 2043-2050 ◽  
Author(s):  
Meei Ling Sheu ◽  
Chih Kang Chiang ◽  
Keh Sung Tsai ◽  
Feng Ming Ho ◽  
Te I Weng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cell ◽  
Nadph Oxidase ◽  
High Glucose ◽  
Cell Apoptosis ◽  
Human Endothelial Cell ◽  
Endothelial Cell Apoptosis

scholarly journals Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion

2018 ◽  
Vol 38 (3) ◽  
Author(s):  
Chengfu Song ◽  
Xiangdong Zhao
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Artery Occlusion ◽  
Vascular Endothelial ◽  
Endothelial Cell Apoptosis ◽  
Related Factors ◽  
Cerebral Artery Occlusion

In patients with cerebral infarction (CI), elevated serum uric acid (UA) level may exacerbate the occurrence and development of carotid atherosclerosis (AS). Our study intended to explore the underlying mechanism. We enrolled 86 patients with CI, and divided them into four groups: Non-AS, AS-mild, AS-moderate, and AS-severe groups; the levels of UA and oxidative stress-related factors in serum were detected. The middle cerebral artery occlusion (MCAO) model was used to stimulate CI in rats, and different doses of UA were administrated. The levels of oxidative stress-related factors in serum were detected. Hematoxylin & eosin (H&E) staining was used to observe the morphological alterations, and the apoptotic cell death detection kit was used to detect apoptotic cells. Increased UA concentration and enhanced oxidative stress were found in AS patients. H&E staining results showed that UA treatment exacerbated morphological damage in rats with MCAO, promoted oxidative stress, and enhanced vascular endothelial cell apoptosis in rats with MCAO.

scholarly journals TAURINE PROTECTS AGAINST STRESS GENE INDUCED HUMAN ENDOTHELIAL CELL APOPTOSIS.

Shock ◽  
1995 ◽  
Vol 3 ◽  
pp. 57
Author(s):  
P. Stapleton ◽  
H. P. Redmond ◽  
J. H. Wang ◽  
R. W.G. Watson ◽  
C. Condron ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Human Endothelial Cell ◽  
Endothelial Cell Apoptosis ◽  
Stress Gene

Exogenous BH4/Bcl-2 Peptide Reverts Coronary Endothelial Cell Apoptosis Induced by Oxidative Stress

2004 ◽  
Vol 41 (2) ◽  
pp. 202-207 ◽  
Author(s):  
S. Cantara ◽  
S. Donnini ◽  
A. Giachetti ◽  
P.E. Thorpe ◽  
M. Ziche
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Endothelial Cell Apoptosis

scholarly journals Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction

2006 ◽  
Vol 22 (3) ◽  
pp. 198-203 ◽  
Author(s):  
Ludovica Piconi ◽  
Lisa Quagliaro ◽  
Roberta Assaloni ◽  
Roberto Da Ros ◽  
Amabile Maier ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
High Glucose ◽  
Cell Apoptosis ◽  
Endothelial Cell Apoptosis ◽  
Mitochondrial Superoxide ◽  
Intermittent High Glucose
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