Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: Possible role of oxidative stress

2010 ◽  
Vol 48 (7) ◽  
pp. 924-934 ◽  
Author(s):  
Ken-ichiro Inoue ◽  
Rie Yanagisawa ◽  
Eiko Koike ◽  
Masataka Nishikawa ◽  
Hirohisa Takano
Keyword(s):  
Oxidative Stress ◽  
Carbon Nanotubes ◽  
Allergic Inflammation ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Pulmonary Exposure ◽  
Walled Carbon Nanotubes

A role of HNO3on transparent conducting film with single-walled carbon nanotubes

2009 ◽  
Vol 20 (47) ◽  
pp. 475703 ◽  
Author(s):  
Dong-Wook Shin ◽  
Jong Hak Lee ◽  
Yu-Hee Kim ◽  
Seong Man Yu ◽  
Seong-Yong Park ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Single Walled Carbon Nanotubes ◽  
Conducting Film ◽  
Single Walled Carbon ◽  
Transparent Conducting Film ◽  
Transparent Conducting ◽  
Walled Carbon Nanotubes

Wrapping of Single-Walled Carbon Nanotubes by a π-Conjugated Polymer: The Role of Polymer Conformation-Controlled Size Selectivity

2008 ◽  
Vol 112 (39) ◽  
pp. 12263-12269 ◽  
Author(s):  
Wenhui Yi ◽  
Andrey Malkovskiy ◽  
Qinghui Chu ◽  
Alexei P. Sokolov ◽  
Marisabel Lebron Colon ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Conjugated Polymer ◽  
Single Walled Carbon Nanotubes ◽  
Polymer Conformation ◽  
Size Selectivity ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

scholarly journals Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis

2008 ◽  
Vol 295 (4) ◽  
pp. L552-L565 ◽  
Author(s):  
A. A. Shvedova ◽  
E. Kisin ◽  
A. R. Murray ◽  
V. J. Johnson ◽  
O. Gorelik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Nanotubes ◽  
Inflammatory Response ◽  
Single Walled Carbon Nanotubes ◽  
Mechanical And Thermal Properties ◽  
Single Walled Carbon ◽  
Pharmaceutical Industries ◽  
Walled Carbon Nanotubes ◽  
Pharyngeal Aspiration ◽  
Granulomatous Pneumonia

Nanomaterials are frontier technological products used in different manufactured goods. Because of their unique physicochemical, electrical, mechanical, and thermal properties, single-walled carbon nanotubes (SWCNT) are finding numerous applications in electronics, aerospace devices, computers, and chemical, polymer, and pharmaceutical industries. SWCNT are relatively recently discovered members of the carbon allotropes that are similar in structure to fullerenes and graphite. Previously, we ( 47 ) have reported that pharyngeal aspiration of purified SWCNT by C57BL/6 mice caused dose-dependent granulomatous pneumonia, oxidative stress, acute inflammatory/cytokine responses, fibrosis, and decrease in pulmonary function. To avoid potential artifactual effects due to instillation/agglomeration associated with SWCNT, we conducted inhalation exposures using stable and uniform SWCNT dispersions obtained by a newly developed aerosolization technique ( 2 ). The inhalation of nonpurified SWCNT (iron content of 17.7% by weight) at 5 mg/m3, 5 h/day for 4 days was compared with pharyngeal aspiration of varying doses (5–20 μg per mouse) of the same SWCNT. The chain of pathological events in both exposure routes was realized through synergized interactions of early inflammatory response and oxidative stress culminating in the development of multifocal granulomatous pneumonia and interstitial fibrosis. SWCNT inhalation was more effective than aspiration in causing inflammatory response, oxidative stress, collagen deposition, and fibrosis as well as mutations of K- ras gene locus in the lung of C57BL/6 mice.

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