Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q10

2011 ◽  
Vol 50 (9) ◽  
pp. 1053-1064 ◽  
Author(s):  
Julio J. Ochoa ◽  
Reinald Pamplona ◽  
M. Carmen Ramirez-Tortosa ◽  
Sergio Granados-Principal ◽  
Patricia Perez-Lopez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dna ◽  
Coenzyme Q10 ◽  
Dietary Fat ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
Age Related ◽  
And Oxidative Stress ◽  
Age Related Changes

Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart

2010 ◽  
Vol 131 (1) ◽  
pp. 38-47 ◽  
Author(s):  
José L. Quiles ◽  
Reinald Pamplona ◽  
M. Carmen Ramirez-Tortosa ◽  
Alba Naudí ◽  
Manuel Portero-Otin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dna ◽  
Rat Heart ◽  
Coenzyme Q ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
Age Related ◽  
And Oxidative Stress

scholarly journals Age-Related Mitochondrial DNA Deletion in Rat Liver Depends on Dietary Fat Unsaturation

2006 ◽  
Vol 61 (2) ◽  
pp. 107-114 ◽  
Author(s):  
José L. Quiles ◽  
Julio J. Ochoa ◽  
M. Carmen Ramirez-Tortosa ◽  
Jesús R. Huertas ◽  
José Mataix
Keyword(s):  
Mitochondrial Dna ◽  
Rat Liver ◽  
Dietary Fat ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
Age Related

scholarly journals Coenzyme Q10, Ageing and the Nervous System: An Overview

Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 2
Author(s):  
David Mantle ◽  
Robert A. Heaton ◽  
Iain P. Hargreaves
Keyword(s):  
Oxidative Stress ◽  
Coenzyme Q10 ◽  
Neurological Disorders ◽  
Neurological Disease ◽  
Age Related ◽  
Increased Risk ◽  
Potential Therapeutic Role ◽  
Ageing Brain ◽  
And Oxidative Stress

The ageing brain is characterised by changes at the physical, histological, biochemical and physiological levels. This ageing process is associated with an increased risk of developing a number of neurological disorders, notably Alzheimer’s disease and Parkinson’s disease. There is evidence that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of such disorders. In this article, we review the potential therapeutic role in these age-related neurological disorders of supplementary coenzyme Q10, a vitamin-like substance of vital importance for normal mitochondrial function and as an antioxidant. This review is concerned primarily with studies in humans rather than in vitro studies or studies in animal models of neurological disease. In particular, the reasons why the outcomes of clinical trials supplementing coenzyme Q10 in these neurological disorders is discussed.

Mitochondrial DNA Deletion Associated Oxidative Stress and Severe Male Osteoporosis

1999 ◽  
Vol 10 (2) ◽  
pp. 143-149 ◽  
Author(s):  
S. S. Varanasi ◽  
R. M. Francis ◽  
C. E. M. Berger ◽  
S. S. Papiha ◽  
H. K. Datta
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dna ◽  
Male Osteoporosis ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion

Increased mitochondrial DNA deletion in the brain of SAMP8, a mouse model for spontaneous oxidative stress brain

1998 ◽  
Vol 254 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Yasuhisa Fujibayashi ◽  
Shoko Yamamoto ◽  
Atsuo Waki ◽  
Junji Konishi ◽  
Yoshiharu Yonekura
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dna ◽  
Mouse Model ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
The Brain
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