Effect of sub-chronic exposure to selenium and Allium mongolicum Regel flavonoids on Channa argus: Bioaccumulation, oxidative stress, immune responses and immune-related signaling molecules

Abstract Hexavalent chromium (Cr (VI)) is a very common and harmful heavy metal pollutant in the world. However, the responses of Cr (VI) to aquatic environmental toxicants have not been well described. In this study, we evaluated the waterborne Cr (VI) [ 0 mg/L (C1), 0.5 mg/L (C2), 1 mg/L (C3), 2 mg/L (C4)] exposed chronically to Channa argus. After 14 and 28 days, we measured biochemical parameters, Cr (VI) accumulation, antioxidant activity and immune response in the serum, liver and gill, respectively. Our results shown that Cr (VI) accumulation will occur in certain tissues as the time of exposure in water prolongs, and the biochemical parameters in the serum will increase. Antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) gradually decreased with the increasing time of Cr (VI) concentration, while the malondialdehyde concentration increases. In addition, in the immune response, cortisol, aminotransferase (ALT), aspartate aminotransferases (AST), alkaline phosphatase (AKP), immunoglobulin M increase, but lysozyme decrease. These results indicated that exposure to waterborne Cr (VI) can exert adverse effects in C. argus by inducing Cr (VI) accumulation, immune responses and oxidative stress.

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Effects of dietary curcumin on growth performance, lipopolysaccharide-induced immune responses, oxidative stress and cell apoptosis in snakehead fish (Channa argus)

Aquaculture Reports ◽

10.1016/j.aqrep.2021.100981 ◽

2022 ◽

Vol 22 ◽

pp. 100981

Author(s):

Min Li ◽

Yidi Kong ◽

Xueqin Wu ◽

Guiliang Guo ◽

Li Sun ◽

...

Keyword(s):

Oxidative Stress ◽

Immune Responses ◽

Growth Performance ◽

Cell Apoptosis ◽

Channa Argus

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Effects of Chronic Exposure to Electromagnetic Waves at 930 MHz Frequency on Oxidative Stress in Plasma and Some Organs of Wistar Rats

PARIPEX-INDIAN JOURNAL OF RESEARCH ◽

10.15373/22501991/july2014/55 ◽

2012 ◽

Vol 3 (7) ◽

pp. 1-7

Author(s):

L. TAZROUT L. TAZROUT ◽

◽

K. TALEA K. TALEA ◽

S. EL AMRANI S. EL AMRANI ◽

I. M’TOUGUY I. M’TOUGUY ◽

...

Keyword(s):

Oxidative Stress ◽

Chronic Exposure ◽

Electromagnetic Waves ◽

Wistar Rats

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Oxidative Stress Compromises Lymphocyte Function in Neonatal Dairy Calves

Antioxidants ◽

10.3390/antiox10020255 ◽

2021 ◽

Vol 10 (2) ◽

pp. 255

Author(s):

Wilmer Cuervo ◽

Lorraine M. Sordillo ◽

Angel Abuelo

Keyword(s):

Oxidative Stress ◽

Immune Responses ◽

Immune Cell ◽

Lymphocyte Activation ◽

Dairy Calves ◽

Lymphocyte Function ◽

Newborn Calves ◽

Ifn Γ ◽

The Impact

Dairy calves are unable to mount an effective immune response during their first weeks of life, which contributes to increased disease susceptibility during this period. Oxidative stress (OS) diminishes the immune cell capabilities of humans and adult cows, and dairy calves also experience OS during their first month of life. However, the impact that OS may have on neonatal calf immunity remains unexplored. Thus, we aimed to evaluate the impact of OS on newborn calf lymphocyte functions. For this, we conducted two experiments. First, we assessed the association of OS status throughout the first month of age and the circulating concentrations of the cytokines interferon-gamma (IFN-γ) and interleukin (IL) 4, as well as the expression of cytokine-encoding genes IFNG, IL2, IL4, and IL10 in peripheral mononuclear blood cells (PBMCs) of 12 calves. Subsequently, we isolated PBMCs from another 6 neonatal calves to investigate in vitro the effect of OS on immune responses in terms of activation of lymphocytes, cytokine expression, and antibody production following stimulation with phorbol 12-myristate 13-acetate or bovine herpesvirus-1. The results were compared statistically through mixed models. Calves exposed to high OS status in their first month of age showed higher concentrations of IL-4 and expression of IL4 and IL10 and lower concentrations of IFN-γ and expression of IFNG and IL2 than calves exposed to lower OS. In vitro, OS reduced lymphocyte activation, production of antibodies, and protein and gene expression of key cytokines. Collectively, our results demonstrate that OS can compromise some immune responses of newborn calves. Hence, further studies are needed to explore the mechanisms of how OS affects the different lymphocyte subsets and the potential of ameliorating OS in newborn calves as a strategy to augment the functional capacity of calf immune cells, as well as enhance calves’ resistance to infections.

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