A novel ferritin L (FerL) in hybrid crucian carp could participate in host defense against Aeromonas hydrophila infection and diminish inflammatory signals

2021 ◽  
Author(s):  
Ning-Xia Xiong ◽  
Jie Ou ◽  
Shi-Yun Li ◽  
Jia-Hui Zhao ◽  
Jin-Fang Huang ◽  
...  
Keyword(s):  
Host Defense ◽  
Aeromonas Hydrophila ◽  
Crucian Carp ◽  
Inflammatory Signals

scholarly journals Recombinant N-acyl homoserine lactone-Lactonase AiiAQSI-1 Attenuates Aeromonas hydrophila Virulence Factors, Biofilm Formation and Reduces Mortality in Crucian Carp

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 499 ◽  
Author(s):  
Bao Zhang ◽  
Xiyi Zhuang ◽  
Liyun Guo ◽  
Robert J. C. McLean ◽  
Weihua Chu
Keyword(s):  
Virulence Factors ◽  
Aeromonas Hydrophila ◽  
Biofilm Formation ◽  
Crucian Carp ◽  
Homoserine Lactone ◽  
In Vivo Studies ◽  
Acyl Homoserine Lactone ◽  
Signal Molecule ◽  
Promising Alternative ◽  
Feed Supplementation

Quorum quenching (QQ) is a promising alternative infection-control strategy to antibiotics that controls quorum-regulated virulence without killing the pathogens. Aeromonas hydrophila is an opportunistic gram-negative pathogen living in freshwater and marine environments. A. hydrophila possesses an N-acyl homoserine lactone (AHL)-based quorum-sensing (QS) system that regulates virulence, so quorum signal-inactivation (i.e., QQ) may represent a new way to combat A. hydrophila infection. In this study, an AHL lactonase gene, aiiA was cloned from Bacillus sp. strain QSI-1 and expressed in Escherichia coli strain BL21(DE3). The A. hydrophila hexanoyl homoserine lactone (C6-HSL) QS signal molecule was degraded by AiiAQSI-1, which resulted in a decrease of bacterial swimming motility, reduction of extracellular protease and hemolysin virulence factors, and inhibited the biofilm formation of A. hydrophila YJ-1 in a microtiter assay. In cell culture studies, AiiAQSI-1 decreased the ability of A. hydrophila adherence to and internalization by Epithelioma papulosum cyprini (EPC) cells. During in vivo studies, oral administration of AiiAQSI-1 via feed supplementation attenuated A. hydrophila infection in Crucian Carp. Results from this work indicate that feed supplementation with AiiAQSI-1 protein has potential to control A. hydrophila aquaculture disease via QQ.

ASC-deficiency impairs host defense against Aeromonas hydrophila infection in Japanese medaka, Oryzias latipes

2020 ◽  
Vol 105 ◽  
pp. 427-437
Author(s):  
Natsuki Morimoto ◽  
Yo Okamura ◽  
Shun Maekawa ◽  
Han-Ching Wang ◽  
Takashi Aoki ◽  
...  
Keyword(s):  
Host Defense ◽  
Aeromonas Hydrophila ◽  
Oryzias Latipes ◽  
Japanese Medaka

scholarly journals Draft Genome Sequence of Aeromonas hydrophila Strain BSK-10 (Serotype O97), Isolated from Carassius carassius with Motile Aeromonad Septicemia in China

2017 ◽  
Vol 5 (24) ◽  
Author(s):  
Xiaoyi Pan ◽  
Lingyun Lin ◽  
Yang Xu ◽  
Xuemei Yuan ◽  
Jiayun Yao ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Aeromonas Hydrophila ◽  
Crucian Carp ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Carassius Carassius ◽  
Content Type

ABSTRACT We report here a draft genome sequence of Aeromonas hydrophila strain BSK-10, belonging to serotype O97, isolated from crucian carp (Carassius carassius) with motile aeromonad septicemia in Zhejiang, China. The assembly resulted in 34 scaffolds totaling approximately 4.97 Mb, with an average G+C content of 60.97% and 4,594 predicted coding genes.

Systemic Iron Homeostasis

2013 ◽  
Vol 93 (4) ◽  
pp. 1721-1741 ◽  
Author(s):  
Tomas Ganz
Keyword(s):  
Host Defense ◽  
Recent Progress ◽  
Iron Homeostasis ◽  
Iron Absorption ◽  
Iron Concentration ◽  
Cellular Iron ◽  
Inflammatory Signals ◽  
Iron Losses ◽  
Total Body

The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes. Because iron losses are comparatively very small, iron absorption and its regulation by hepcidin and ferroportin determine total body iron content. Hepcidin is in turn feedback-regulated by plasma iron concentration and iron stores, and negatively regulated by the activity of erythrocyte precursors, the dominant consumers of iron. Hepcidin and ferroportin also play a role in host defense and inflammation, and hepcidin synthesis is induced by inflammatory signals including interleukin-6 and activin B. This review summarizes and discusses recent progress in molecular characterization of systemic iron homeostasis and its disorders, and identifies areas for further investigation.

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