Walking endurance in multiple sclerosis: Meta-analysis of six-minute walk test performance

AbstractGait impairments in persons with multiple sclerosis (pwMS) underlying reduced walking endurance are still poorly understood. Thus, our objective was to assessed gait asymmetry (GA) and bilateral coordination of gait (BCG), among pwMS during the six-minute walk test (6MWT) and their association with disease severity. For this aim, we recruited ninety-two pwMS (age: 46.6 ± 7.9; 83% females) with a broad range of clinical disability who completed the 6MWT wearing gait analysis system. GA was assessed by comparing left and right swing times, and BCG by using the phase coordination index (PCI). Several functional and subjective gait assessments were performed. Results show that gait is more asymmetric and less coordinated as the disease progresses (p<.0001). Participants with mild MS showed significant better BCG as reflected by lower PCI values in comparison to the other two MS severity groups (severe: p =.001, moderate: p=.02). GA and PCI also deteriorated significantly with time during the 6MWT (p<.0001). GA and PCI (i.e., BCG) show somewhat weaker associations with clinical MS status than associations observed between functional and subjective gait assessments and MS status. Similar to other neurological cohorts, GA and PCI are important parameters to assess and to target in interventions among pwMS.

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Protocol Variations and Six-Minute Walk Test Performance in Stroke Survivors: A Systematic Review with Meta-Analysis

Stroke Research and Treatment ◽

10.1155/2015/484813 ◽

2015 ◽

Vol 2015 ◽

pp. 1-28 ◽

Cited By ~ 26

Author(s):

A. Dunn ◽

D. L. Marsden ◽

E. Nugent ◽

P. Van Vliet ◽

N. J. Spratt ◽

...

Keyword(s):

Test Performance ◽

Observational Studies ◽

Intervention Studies ◽

Meta Analysis ◽

Stroke Survivors ◽

Walking Ability ◽

Walk Test ◽

Inclusion Criteria ◽

Six Minute Walk Test ◽

Minute Walk

Objective. To investigate the use of the six-minute walk test (6MWT) for stroke survivors, including adherence to 6MWT protocol guidelines and distances achieved.Methods. A systematic search was conducted from inception to March 2014. Included studies reported a baseline (intervention studies) or first instance (observational studies) measure for the 6MWT performed by stroke survivors regardless of time after stroke. Results. Of 127 studies (participantsn= 6,012) that met the inclusion criteria, 64 were also suitable for meta-analysis. Only 25 studies made reference to the American Thoracic Society (ATS) standards for the 6MWT, and 28 reported using the protocol standard 30 m walkway. Thirty-nine studies modified the protocol walkway, while 60 studies did not specify the walkway used. On average, stroke survivors walked 284 ± 107 m during the 6MWT, which is substantially less than healthy age-matched individuals. The meta-analysis identified that changes to the ATS protocol walkway are associated with reductions in walking distances achieved.Conclusion. The 6MWT is now widely used in stroke studies. The distances achieved by stroke patients indicate substantially compromised walking ability. Variations to the standard 30 m walkway for the 6MWT are common and caution should be used when comparing the values achieved from studies using different walkway lengths.

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THE IMPACT OF SIX–MINUTE WALK TEST PERFORMANCE ON OUTCOMES AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT: INSIGHTS FROM THE PARTNER TRIAL

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(13)61971-3 ◽

2013 ◽

Vol 61 (10) ◽

pp. E1971 ◽

Cited By ~ 2

Author(s):

Philip Green ◽

Ajay Kirtane ◽

Philippe Genereux ◽

Tom McAndrew ◽

Irene Hueter ◽

...

Keyword(s):

Aortic Valve ◽

Aortic Valve Replacement ◽

Valve Replacement ◽

Test Performance ◽

Transcatheter Aortic Valve Replacement ◽

Walk Test ◽

Six Minute Walk Test ◽

Transcatheter Aortic Valve ◽

The Impact ◽

Minute Walk

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Abstract 17469: Comparing the Effect of CRT Implantation on Quality of Life in Older Patients Compared With Younger Patients: Systematic Review and Meta-Analysis

Circulation ◽

10.1161/circ.142.suppl_3.17469 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Praveen Ponnamreddy ◽

Saeed Juggan ◽

Lauren Gilstrap

Keyword(s):

Quality Of Life ◽

Older Patients ◽

Meta Analysis ◽

Nyha Class ◽

Age Group ◽

Walk Test ◽

Younger Patients ◽

Six Minute Walk Test ◽

Minute Walk

Background: CRT had been accepted as standard of care for patients with HFrEF who qualify for the therapy. The pivotal CRT trials enrolled patients significantly younger than the typical HFrEF patients seen in the community. Benefits of CRT in older HFrEF patients is largely unknown. We sought to evaluate the change in quality of life in older patients undergoing CRT in comparison to younger patients. Hypothesis: CRT implantation is associated with comparable improvements in quality of life in younger patients (age <70) and older patients (age 70 and above). Methods: PubMed, The Cochrane Library, Scopus, and Web of Science were queried for comparative effectiveness studies of CRT in older HFrEF patients. We gathered data for Quality of life measurements including improvement in NYHA class, MLHFQ, Six minute walk test. MLHFQ, Six minute walk test data was analyzed qualitatively as data was insufficient to impute Standard deviation for mean change. Changes in NYHA class was analyzed quantitatively. Random effects meta-analysis of improvement in NYHA class and relative risk (RR) is reported along with estimates of heterogeneity Results: Seven studies [n=2494 for younger group and n=1035 for older group] were included in changes in NYHA class meta-analysis. Older age group patients had similar improvement in NYHA class compared to younger age group patients. Relative risk 0.99 with 95%CI 0.93-1.06 (figure). Five studies reported Baseline and follow up MLHFQ scores for both the groups. All the five studies reported improvements in MLHFQ in both the groups. Three studies reported change in six minute walk test in meters before and after CRT implantation. All the studies reported improvement in six minute walk test both in younger and older group. Conclusions: People older than 70 years of age with heart failure with reduced ejection fraction who qualify for CRT derive similar benefits with improvement in quality of life compared to patients aged less than 70 years of age.

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