Reliability and minimum detectable change of measures of gait in children during walking and running on an instrumented treadmill

2020 ◽  
Vol 75 ◽  
pp. 105-108 ◽  
Author(s):  
Simon C. McSweeney ◽  
Lloyd F. Reed ◽  
Scott C. Wearing
Keyword(s):  
Detectable Change ◽  
Minimum Detectable Change ◽  
Change Of Measures

scholarly journals Minimum Detectable Change of Visual Acuity Measurements Using ETDRS Charts (Early Treatment Diabetic Retinopathy Study)

2021 ◽  
Vol 18 (15) ◽  
pp. 7876
Author(s):  
María Carmen Sánchez-González ◽  
Raquel García-Oliver ◽  
José-María Sánchez-González ◽  
María-José Bautista-Llamas ◽  
José-Jesús Jiménez-Rejano ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Early Treatment ◽  
High Reliability ◽  
Minimal Detectable Change ◽  
High Contrast ◽  
Detectable Change ◽  
Low Contrast ◽  
Minimum Detectable Change ◽  
The Mean

In our work, we determined the value of visual acuity (VA) with ETDRS charts (Early Treatment Diabetic Retinopathy Study). The purpose of the study was to determine the measurement reliabilities, calculating the correlation coefficient interclass (ICC), the value of the error associated with the measure (SEM), and the minimal detectable change (MDC). Forty healthy subjects took part. The mean age was 23.5 ± 3.1 (19 to 26) years. Visual acuities were measured with ETDRS charts (96% ETDRS chart nº 2140) and (10% SLOAN Contrast Eye Test chart nº 2153). The measurements were made (at 4 m) under four conditions: Firstly, photopic conditions with high contrast (HC) and low contrast (LC) and after 15 min of visual rest, mesopic conditions with high and low contrast. Under photopic conditions and high contrast, the ICC = 0.866 and decreased to 0.580 when the luminosity and contrast decreased. The % MDC in the four conditions was always less than 10%. It was minor under photopic conditions and HC (5.83) and maximum in mesopic conditions and LC (9.70). Our results conclude a high reliability of the ETDRS test, which is higher in photopic and high contrast conditions and lower when the luminosity and contrast decreases.

Minimum clinically important difference in pain, disability, and quality of life after neural decompression and fusion for same-level recurrent lumbar stenosis: understanding clinical versus statistical significance

2012 ◽  
Vol 16 (5) ◽  
pp. 471-478 ◽  
Author(s):  
Scott L. Parker ◽  
Stephen K. Mendenhall ◽  
David N. Shau ◽  
Owoicho Adogwa ◽  
William N. Anderson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Minimum Clinically Important Difference ◽  
Leg Pain ◽  
Lumbar Stenosis ◽  
Detectable Change ◽  
Calculation Methods ◽  
Recurrent Stenosis ◽  
Minimum Detectable Change ◽  
Clinically Important Difference

Object Spine surgery outcome studies rely on patient-reported outcome (PRO) measurements to assess treatment effect, but the extent of improvement in the numerical scores of these questionnaires lacks a direct clinical meaning. Because of this, the concept of a minimum clinically important difference (MCID) has been used to measure the critical threshold needed to achieve clinically relevant treatment effectiveness. As utilization of spinal fusion has increased over the past decade, so has the incidence of same-level recurrent stenosis following index lumbar fusion, which commonly requires revision decompression and fusion. The MCID remains uninvestigated for any PROs in the setting of revision lumbar surgery for this pathology. Methods In 53 consecutive patients undergoing revision surgery for same-level recurrent lumbar stenosis–associated back and leg pain, PRO measures of back and leg pain were assessed preoperatively and 2 years postoperatively, using the visual analog scale for back pain (VAS-BP) and leg pain (VAS-LP), Oswestry Disability Index (ODI), Physical and Mental Component Summary categories of the 12-Item Short Form Health Survey (SF-12 PCS and MCS) for quality of life, Zung Depression Scale (ZDS), and EuroQol-5D health survey (EQ-5D). Four established anchor-based MCID calculation methods were used to calculate MCID (average change; minimum detectable change; change difference; and receiver operating characteristic curve analysis) for 2 separate anchors (health transition index of the SF-36 and the satisfaction index). Results All patients were available for 2-year PRO assessment. Two years after surgery, a significant improvement was observed for all PROs assessed. The 4 MCID calculation methods generated a range of MCID values for each of the PROs (VAS-BP 2.2–6.0, VAS-LP 3.9–7.5, ODI 8.2–19.9, SF-12 PCS 2.5–12.1, SF-12 MCS 7.0–15.9, ZDS 3.0–18.6, and EQ-5D 0.29–0.52). Each patient answered synchronously for the 2 anchors, suggesting both of these anchors are equally appropriate and valid for this patient population. Conclusions The same-level recurrent stenosis surgery-specific MCID is highly variable based on calculation technique. The “minimum detectable change” approach is the most appropriate method for calculation of MCIDs in this population because it was the only method to reliably provide a threshold above the 95% confidence interval of the unimproved cohort (greater than the measurement error). Based on this method, the MCID thresholds following neural decompression and fusion for symptomatic same-level recurrent stenosis are 2.2 points for VAS-BP, 5.0 points for VAS-LP, 8.2 points for ODI, 2.5 points for SF-12 PCS, 10.1 points for SF-12 MCS, 4.9 points for ZDS, and 0.39 QALYs for EQ-5D.

Detecting change in community participation with the Enfranchisement scale of the community participation indicators

2021 ◽  
pp. 026921552110521
Author(s):  
Jessica Kersey ◽  
Lauren Terhorst ◽  
Joy Hammel ◽  
Carolyn Baum ◽  
Joan Toglia ◽  
...  
Keyword(s):  
Community Participation ◽  
Functional Independence Measure ◽  
Minimum Clinically Important Difference ◽  
Functional Independence ◽  
Baseline Score ◽  
Sensitivity To Change ◽  
Detectable Change ◽  
Change Scores ◽  
Minimum Detectable Change ◽  
Clinically Important Difference

Objective This study determined the sensitivity to change of the Enfranchisement scale of the Community Participation Indicators in people with stroke. Data sources We analyzed data from two studies of participants with stroke: an intervention study and an observational study. Main measures The Enfranchisement Scale contains two subscales: the Importance subscale (feeling valued by and contributing to the community; range: 14–70) and the Control subscale (choice and control: range: 13–64). Data analysis Assessments were administered 6 months apart. We calculated minimum detectable change and minimal clinically important difference. Results The Control subscale analysis included 121 participants with a mean age of 61.2 and mild-moderate disability (Functional Independence Measure, mean = 97.9, SD = 24.7). On the Control subscale, participants had a mean baseline score of 51.4 (SD = 10.4), and little mean change (1.3) but with large variation in change scores (SD = 11.5). We found a minimum detectable change of 9 and a minimum clinically important difference of 6. The Importance subscale analysis included 116 participants with a mean age of 60.7 and mild-moderate disability (Functional Independence Measure, mean = 98.9, SD = 24.5). On the Importance subscale, participants had a mean baseline score of 44.1 (SD = 12.7), and again demonstrated little mean change (1.08) but with large variation in change scores (SD = 12.6). We found a minimum detectable change of 11 and a minimum clinically important difference 7. Conclusions The Control subscale required 9 points of change, and the Importance subscale required 11 points of change, to achieve statistically and clinically meaningful changes, suggesting adequate sensitivity to change.

Reliability and minimum detectable change of the gait profile score for post-stroke patients

2016 ◽  
Vol 49 ◽  
pp. 382-387 ◽  
Author(s):  
Gisele Francini Devetak ◽  
Suzane Ketlyn Martello ◽  
Juliana Carla de Almeida ◽  
Katren Pedroso Correa ◽  
Dielise Debona Iucksch ◽  
...  
Keyword(s):  
Detectable Change ◽  
Stroke Patients ◽  
Post Stroke ◽  
Minimum Detectable Change ◽  
Profile Score

scholarly journals Determination of the Minimum Detectable Change in the Total and Segmental Volumes of the Upper Limb, Evaluated by Perimeter Measurements

Healthcare ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 285
Author(s):  
José Manuel Tánori-Tapia ◽  
Ena Monserrat Romero-Pérez ◽  
Néstor Antonio Camberos ◽  
Mario A. Horta-Gim ◽  
Gabriel Núñez-Othón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Upper Limb ◽  
Breast Cancer Survivors ◽  
Female Breast Cancer ◽  
Minimal Detectable Change ◽  
Axillary Lymph ◽  
Detectable Change ◽  
Minimum Detectable Change

Among female breast cancer survivors, there is a high prevalence of lymphedema subsequent to axillary lymph node dissection and axillary radiation therapy. There are many methodologies available for the screening, diagnosis and follow-up of breast cancer survivors with or without lymphedema, the most common of which is the measurement of patients’ arm circumference. The purpose of this study was to determine the intra-rater minimal detectable change (MDC) in the volume of the upper limb, both segmentally and globally, using circumference measurements for the evaluation of upper limb volume. In this study, 25 women who had received a unilateral mastectomy for breast cancer stage II or III participated. On two occasions separated by 15 min, the same researcher determined 11 perimeters for each arm at 4 cm intervals from the distal crease of the wrist in the direction of the armpit. The MDC at the segmental level ranged from 3.37% to 7.57% (2.7 to 14.6 mL, respectively) and was 2.39% (42.9 mL) at the global level of the arm; thus, minor changes in this value result in a high level of uncertainty in the interpretation of the results associated with the diagnosis of lymphedema and follow-up for presenting patients.

Cross-cultural adaptation and measurement properties of the Patient-Rated Tennis Elbow Evaluation for the Persian language

Hand Therapy ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 56-62 ◽  
Author(s):  
Erfan Shafiee ◽  
Maryam Farzad ◽  
Joy Macdermid ◽  
Amirreza Smaeel Beygi ◽  
Atefeh Vafaei ◽  
...  
Keyword(s):  
Standard Error ◽  
Cultural Adaptation ◽  
Convergent Validity ◽  
Tennis Elbow ◽  
Cross Cultural ◽  
Detectable Change ◽  
Cross Cultural Adaptation ◽  
Minimum Detectable Change ◽  
Standard Error Of Measurement ◽  
Error Of Measurement

Introduction The Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire is a tool designed for self-assessment of forearm pain and disability in patients with tennis elbow. The aims of this study were to translate and cross-culturally adapt the PRTEE questionnaire into Persian and evaluate its reliability and construct validity. Methods The PRTEE questionnaire was translated into and cross-culturally adapted to Persian in 90 consecutive patients with tennis elbow, according to well-established guidelines. Reliability was tested by means of test–retest and internal consistency. The measurement error was measured by calculating the standard error of measurement. Based on the standard error of measurement, the minimum detectable change was calculated. To evaluate construct and convergent validity, correlation with the PRTEE with the Disabilities of the Arm, Shoulder and Hand questionnaire and Visual analogue scale was used. Results In the process of cross-cultural adaptation, two items (6 and 8) were modified. In item 6, the term “door knob” was changed to “turn a key”, and in the item 8, “cup of coffee” was changed to “cup of milk”. Item-total correlations were greater than 0.55 (ranged from 0.55 to 0.76), internal consistency was high (Cronbach’s alpha, 0.94) and a high intraclass correlation coefficient (0.98) indicated excellent reliability of the P-PRTEE. The standard error of measurement and minimum detectable change were 5.40 and 14.24, respectively. The Persian version of the PRTEE questionnaire (P-PRTEE) shows strong construct and convergent validity ( r values = 0.85, p < 0.05). Conclusions The P-PRTEE is valid and reliable in assessing disability and pain in Persian patients with tennis elbow. The excellent psychometric properties of the P-PRTEE endorse the use of this questionnaire in clinical settings.

The Measurement of Potassium Efflux in Superfused Frog Sartorius Muscles

1972 ◽  
Vol 50 (2) ◽  
pp. 123-131 ◽  
Author(s):  
G. E. Lucier ◽  
G. W. Mainwood
Keyword(s):  
Gas Phase ◽  
Water Movement ◽  
Potassium Content ◽  
Sartorius Muscle ◽  
Detectable Change ◽  
Electrochemical Gradient ◽  
Potassium Efflux ◽  
Minimum Detectable Change ◽  
Potassium Flux ◽  
Frog Sartorius

A method of measuring net potassium flux in isolated frog sartorius muscles is described. The method depends on superfusing muscles at a slow rate in a gas phase so that a thin film of fluid is maintained on the surface. The effluent is analyzed and efflux determined by the product of flow rate and concentration change. Compartment volumes are measured and water movement is monitored by 14C-inulin. A mean resting net efflux of 25 nequiv/g/min or 0.9 pequiv/cm2/s is given in Ringers containing 2.5 mequiv/l potassium. Diffusion limits the response time of the system so that it is only possible to estimate mean flux rates over intervals of the order of 10–20 min. The minimum detectable change in potassium content of the muscle with this system is about 3.5 nequiv or approximately 0.04% of the average potassium content of the sartorius muscle. The increase in net efflux measured during activity (3.7 pequiv/cm2 per impulse) represents only about half the expected value. This is probably due to reentry of potassium with the electrochemical gradient resulting from the increased extracellular concentration. The addition of ouabain to the superfusion fluid results in an increase of potassium efflux to about four times the resting level (85 nequiv/g/min).

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