Influence of the estrous cycle on hypoxic failure in the female rat heart

2009 ◽  
Vol 6 (4) ◽  
pp. 596-603 ◽  
Author(s):  
Tom L. Broderick ◽  
Peter Wong
Keyword(s):  
Estrous Cycle ◽  
Rat Heart ◽  
Female Rat

scholarly journals In female rat heart mitochondria, oophorectomy results in loss of oxidative phosphorylation

2017 ◽  
Vol 232 (2) ◽  
pp. 221-235 ◽  
Author(s):  
Natalia Pavón ◽  
Alfredo Cabrera-Orefice ◽  
Juan Carlos Gallardo-Pérez ◽  
Cristina Uribe-Alvarez ◽  
Nadia A Rivero-Segura ◽  
...  
Keyword(s):  
Rat Heart ◽  
Complex I ◽  
Adenine Nucleotide ◽  
Mitochondrial Respiratory Chain ◽  
Mitochondrial Enzymes ◽  
Female Rat ◽  
Adult Rats ◽  
Mitochondrial Alterations ◽  
Rat Heart Mitochondria ◽  
Estrogen Depletion

Oophorectomy in adult rats affected cardiac mitochondrial function. Progression of mitochondrial alterations was assessed at one, two and three months after surgery: at one month, very slight changes were observed, which increased at two and three months. Gradual effects included decrease in the rates of oxygen consumption and in respiratory uncoupling in the presence of complex I substrates, as well as compromised Ca2+ buffering ability. Malondialdehyde concentration increased, whereas the ROS-detoxifying enzyme Mn2+ superoxide dismutase (MnSOD) and aconitase lost activity. In the mitochondrial respiratory chain, the concentration and activity of complex I and complex IV decreased. Among other mitochondrial enzymes and transporters, adenine nucleotide carrier and glutaminase decreased. 2-Oxoglutarate dehydrogenase and pyruvate dehydrogenase also decreased. Data strongly suggest that in the female rat heart, estrogen depletion leads to progressive, severe mitochondrial dysfunction.

Estrous cycle variation of afferent fibers supplying reproductive organs in the female rat

1992 ◽  
Vol 596 (1-2) ◽  
pp. 353-356 ◽  
Author(s):  
Ann Robins ◽  
Karen J. Berkley ◽  
Yuko Sato
Keyword(s):  
Estrous Cycle ◽  
Reproductive Organs ◽  
Female Rat ◽  
Cycle Variation ◽  
Afferent Fibers

scholarly journals Evidence of Altered Mitochondrial Protein Expression After Chronic Ethanol Consumption in the Aged Estrogen-Deficient Female Rat Heart

2017 ◽  
Vol 41 (7) ◽  
pp. 1288-1297 ◽  
Author(s):  
Alexandra M. Garvin ◽  
Jennifer L. Miller-Lee ◽  
Daniel R. Sharda ◽  
Gregory M. Kanski ◽  
J. Craig Hunter ◽  
...  
Keyword(s):  
Protein Expression ◽  
Rat Heart ◽  
Mitochondrial Protein ◽  
Ethanol Consumption ◽  
Chronic Ethanol ◽  
Female Rat ◽  
Chronic Ethanol Consumption

scholarly journals Estrogen Receptor Beta Does Not Influence Ischemic Tolerance in the Aged Female Rat Heart

2011 ◽  
Vol 31 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Nanette J. Tomicek ◽  
Jennifer L. Miller-Lee ◽  
J. Craig Hunter ◽  
Donna H. Korzick
Keyword(s):  
Estrogen Receptor ◽  
Rat Heart ◽  
Estrogen Receptor Beta ◽  
Ischemic Tolerance ◽  
Female Rat ◽  
Receptor Beta

scholarly journals Local Cerebral Glucose Utilization in Normal Female Rats: Variations during the Estrous Cycle and Comparison with Males

1985 ◽  
Vol 5 (3) ◽  
pp. 393-400 ◽  
Author(s):  
Astrid Nehlig ◽  
Linda J. Porrino ◽  
Alison M. Crane ◽  
Louis Sokoloff
Keyword(s):  
Estrous Cycle ◽  
Glucose Utilization ◽  
Brain Regions ◽  
Female Rats ◽  
Male Rats ◽  
Normal Male ◽  
Normal Female ◽  
Female Rat ◽  
Males And Females ◽  
The Brain

The quantitative 2-[14C]deoxyglucose autoradiographic method was used to study the fluctuations of energy metabolism in discrete brain regions of female rats during the estrous cycle. A consistent though statistically nonsignificant cyclic variation in average glucose utilization of the brain as a whole was observed. Highest levels of glucose utilization occurred during proestrus and metestrus, whereas lower rates were found during estrus and diestrus. Statistically significant fluctuations were found specifically in the hypothalamus and in some limbic structures. Rates of glucose utilization in the female rat brain were compared with rates in normal male rats. Statistically significant differences between males and females at any stage of the estrous cycle were confined mainly to hypothalamic areas known to be involved in the control of sexual behavior. Glucose utilization in males and females was not significantly different in most other cerebral structures.

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