scholarly journals FOXM1c is the predominant FOXM1 isoform expressed in cholangiocarcinoma that associated with metastatic potential and poor prognosis of patients

Heliyon ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. e06846
Author(s):  
Nathakan Klinhom-on ◽  
Wunchana Seubwai ◽  
Kanlayanee Sawanyawisuth ◽  
Worachart Lert-itthiporn ◽  
Sakda Waraasawapati ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Metastatic Potential

scholarly journals Hypoxia and the Tumor Microenvironment

2021 ◽  
Vol 20 ◽  
pp. 153303382110363
Author(s):  
Yue Li ◽  
Long Zhao ◽  
Xiao-Feng Li
Keyword(s):  
Immune Response ◽  
Cell Proliferation ◽  
Tumor Microenvironment ◽  
Tumor Progression ◽  
Poor Prognosis ◽  
Tumor Biology ◽  
Metastatic Potential ◽  
Tumor Detection ◽  
Tumor Aggressiveness

Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.

High level of TXNDC9 predicts poor prognosis and contributes to the NF-κB-regulated metastatic potential in gastric cancer

Neoplasma ◽  
2021 ◽  
Author(s):  
Qun-Cao Yang ◽  
Nan Hao ◽  
Rui-Hua Li ◽  
Yuan-Yuan Duan ◽  
Yong Zhang
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level

scholarly journals High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (29) ◽  
pp. 46042-46055 ◽  
Author(s):  
Chao Li ◽  
Jian Chen ◽  
Yupeng Wang ◽  
Guohe Song ◽  
Chao Xiao ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

scholarly journals Correction: High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (27) ◽  
pp. 45031-45031 ◽  
Author(s):  
Chao Li ◽  
Jian Chen ◽  
Yupeng Wang ◽  
Guohe Song ◽  
Chao Xiao ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

scholarly journals Loss of expression of Syndecan-1 is associated with Tumor Recurrence, Metastatic Potential, and Poor Survival in patients with Colorectal carcinoma

2020 ◽  
Vol 37 (1) ◽  
Author(s):  
Jaudah Ahmed Al-Maghrabi
Keyword(s):  
Colorectal Carcinoma ◽  
Poor Prognosis ◽  
Tumor Recurrence ◽  
Disease Free Survival ◽  
Metastatic Potential ◽  
University Hospital ◽  
Clinicopathological Parameters ◽  
Poor Survival ◽  
Primary Tumors ◽  
Potential Biomarker

Objective: The loss of expression of syndecansyndecan-1 is associated with poor prognosis in many types of human cancer. The objective of this study was to evaluate the relation between syndecan-1 immunoexpression and several clinicopathological parameters in a subset of colorectal carcinoma (CRC) patients. Methods: Pathology tissue blocks of 202 primary tumors, 41 adenomas, and 37 normal colonic mucosae were used in this study. The cases diagnosed in the period 1995–2015 was included in the study. Immunohistochemistry analysis was performed using anti-CD138/syndecan-1 (B-A38) mouse monoclonal antibody. A semiquantitative method was used to score the syndecan-1 expression based on an evaluation of the percentage and intensity of the membranous and cytoplasmic expression. The data collected from Pathology Department at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. This is a retrospective cohort study that was conducted from July 2018 until August 2019. Results: Loss of syndecan-1 immunoexpression was observed in 72 (42.6%), 5 (12.2%), and 3 (8.1%) cases of CRC, adenomas, and normal mucosae, respectively. Low expression of syndecan-1 showed an association with nodal (p=0.003) and distant (p=0.001) metastasis, lymphovascular invasion (p=0.001), and tumor recurrence (p=0.006). Low syndecan-1 expression were associated with short overall survival (OS) (log rank 4.019, p=0.045) and disease-free survival (DFS) probabilities (log rank 4.748, p=0.029). Conclusion: Loss of syndecan-1 immunoexpression is associated with metastatic potential, tumor recurrence and shorter survival in CRC and is considered a potential biomarker of poor prognosis in CRC patients. doi: https://doi.org/10.12669/pjms.37.1.2592 How to cite this:Al-Maghrabi J. Loss of expression of Syndecan-1 is associated with Tumor Recurrence, Metastatic Potential, and Poor Survival in patients with Colorectal carcinoma. Pak J Med Sci. 2021;37(1):114-120. doi: https://doi.org/10.12669/pjms.37.1.2592 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

High expression of a Lewis(x)-related epitope in gastric carcinomas indicates metastatic potential and poor prognosis

1996 ◽  
Vol 111 (6) ◽  
pp. 1433-1446 ◽  
Author(s):  
B Mayer ◽  
I Funke ◽  
JP Johnson
Keyword(s):  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Expression ◽  
Lewis X ◽  
Gastric Carcinomas

scholarly journals Activation of β-Catenin by Hypoxia in Hepatocellular Carcinoma Contributes to Enhanced Metastatic Potential and Poor Prognosis

2010 ◽  
Vol 16 (10) ◽  
pp. 2740-2750 ◽  
Author(s):  
Liang Liu ◽  
Xiao-Dong Zhu ◽  
Wen-Quan Wang ◽  
Yuan Shen ◽  
Yi Qin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential

scholarly journals High expression of periostin is dramatically associated with metastatic potential and poor prognosis of patients with osteosarcoma

2014 ◽  
Vol 12 (1) ◽  
pp. 287 ◽  
Author(s):  
Fei Hu ◽  
Wei Wang ◽  
Hang-Cheng Zhou ◽  
Xi-Fu Shang
Keyword(s):  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Expression

High-level expression of periostin is closely related to metastatic potential and poor prognosis of hepatocellular carcinoma

2012 ◽  
Vol 30 (1) ◽  
Author(s):  
Yang Lv ◽  
Wei Wang ◽  
Wei-Dong Jia ◽  
Qi-Kai Sun ◽  
Jian-Sheng Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Poor Prognosis ◽  
Metastatic Potential ◽  
High Level Expression ◽  
High Level

scholarly journals The Role of HOX Genes as Potential Biomarkers in Colorectal Cancer: A Systematic Review

2021 ◽  
Author(s):  
Eirini Martinou ◽  
Giulia Falgari ◽  
Angeliki Angelidi ◽  
Izhar Bagwan
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Systematic Reviews ◽  
Poor Prognosis ◽  
Tumour Growth ◽  
Metastatic Potential ◽  
Current Evidence ◽  
Hox Proteins ◽  
The Impact

Abstract Background: Colorectal cancer (CRC) is worldwide the third leading cause of cancer-related death, and despite therapeutic advances, survival remains low. Emerging evidence shows that Homeobox (HOX) genes are important in carcinogenesis, and their dysregulation has been linked with metastatic potential and poor prognosis. This systematic review aims to present the current evidence on the role of HOX genes as biomarkers in CRC and the impact of their modulation in tumour growth and progression. Methods: MEDLINE, EMBASE, Web of Science and Cochrane databases were searched by following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Eligible studies investigated two research questions: a) the clinicopathological and prognostic significance of HOX gene dysregulation in patients with CRC and b) the functional role of HOX genes in CRC progression. This study was registered in the international prospective register of systematic reviews (PROSPERO), CRD42020190953. Results: Twenty-five studies enrolling 3003 patients with stage I-IV CRC, showed that 26 out of 39 HOX genes were dysregulated in cancerous versus normal colon. Aberrant expression of HOX proteins was significantly related to tumour depth, nodal invasion, distant metastases, advanced stage and poor prognosis. Twenty-two preclinical studies showed that HOX proteins are crucially related to tumour growth and metastatic potential by affecting cell proliferation and altering the expression of epithelial-mesenchymal transition modulators. Conclusions: In conclusion, our findings suggest that HOX proteins play vital roles in CRC progression and significantly affect survival. Further research, though, is required to elucidate their potential role as biomarkers in CRC.

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