scholarly journals Up-regulation of FOXN3-AS1 in invasive ductal carcinoma of breast cancer patients

Heliyon ◽  
2021 ◽  
Vol 7 (10) ◽  
pp. e08179
Author(s):  
Samira Molaei Ramshe ◽  
Hamid Ghaedi ◽  
Mir Davood Omrani ◽  
Lobat Geranpayeh ◽  
Behnam Alipour ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Breast Cancer Patients

scholarly journals MMP-2 levels evaluation and their relationship with breast cancer progression.

2020 ◽  
Vol 27 (02) ◽  
pp. 424-430
Author(s):  
Ifrah Yaqoob ◽  
Muhammad Saeed ◽  
Aysha Azhar
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Invasive Ductal Carcinoma ◽  
Cancer Progression ◽  
Ductal Carcinoma ◽  
Histological Type ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
The University

Matrix metalloproteinases (MMPs) play significant part in the tumor development, metastasis and invasion by proteolytic degradation of basement membrane and extracellular matrix. Hence MMPs can serve as good biomarkers for carcinoma breast particularly MMP-2 in our population. Objectives: To measure the concentrations of MMP-2 in plasma of breast cancer patients and establishing their correlation with stage and grade of the disease. Study Design: Comparative cross sectional. Setting: Surgery department Madinah Teaching Hospital (MTH) and the Pathology department, The University of Faisalabad (TUF), Faisalabad. Period: 1st August, 2017 to 31st December, 2017. Material & Methods: Only females with diagnosed breast cancer disease along with staging and grading were included in the study. Females with incomplete reports, on chemotherapy or radiotherapy or having other diseases like oral squamous cell carcinoma, rheumatoid arthritis etc were excluded. ELISA kit was applied to measure the concentrations of MMP-2 in plasma of the participants. OD values were calculated at 450 nm by ELISA reader placed at Post Graduate Research Laboratory, The University of Faisalabad, Faisalabad. Data was gathered and results were finalized by using SPSS 22 for statistical assessment. Results: Age of 64(72%) breast cancer patients was within range of 30-76yrs and age for 25(28%) healthy females as controls range was 18-70yrs. Difference between ages of cases and controls using t-test was statistically highly significant. Ninety five percent cases showed invasive ductal carcinoma (IDC) as histological type. Range of MMP-2 levels in cases was 80-690 ng/mL with mean 451.02 while range of MMP-2 levels in controls was 65-830ng/mL with mean 329.72 showing statistically significant difference. Relationship of different groups of MMP-2 levels in cases with stages of breast cancer was established using chi-square test which was statistically significant, stage IIB (37.5%) and IIIA (34.4%) tumors showed higher values of MMP-2. Relationship between MMP-2 levels, grade, tumor size and node invasion was nonsignificant statistically. Conclusion: MMP-2 levels were raised in cases in comparison to healthy controls. Age of majority patients was > 45 yrs while the invasive ductal carcinoma was the main histological type. MMP-2 levels were associated with stage of the disease.

scholarly journals Variation of Tumour Size Measurements Between Radiology and Pathology

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Breast Cancer ◽  
Retrospective Study ◽  
Breast Carcinoma ◽  
Cancer Patients ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Tumour Size ◽  
Breast Cancer Patients ◽  
Management Planning ◽  
Radiology And Pathology

The aim of this study is to determine the accuracy of the preoperative measurement of tumour size, by imaging modalities and whether they deviate from the postoperative pathological measurement in breast cancer. Material and methods: retrospective study done at King Fahad Hospital of University. For two years 2014-2015 all breast cancer patients included studied by reviewing US which was reported by two radiologists and gross size reports by five pathologists. The correlation of ultrasound, with pathology was studied. Results: 118 cases were collected from January 2014 to December 2015 with diagnosis of breast carcinoma. 36 patients were excluded from the study. Finally, a total of 82 were included in the analysis. Invasive ductal carcinoma (IDC) found in 57 patients (69.5%), 44 patients (53.7%) underwent breast conserving surgeries. 46 patient (56.1%) found to be either over or underestimated by US or Pathology. Conclusion: Despite the importance of accuracy of tumour size in management planning this study reflect marked discrepancy in sizes. More collaboration between radiologist and pathologist will yield accurate measurement, which will impact positively on outcome.

scholarly journals Does Concomitant DCIS Affect the Clinical Outcome in Breast Cancer Patients with Invasive Ductal Carcinoma: an Asian Perspective

2021 ◽  
Author(s):  
Wai Peng Lee ◽  
Spoorthi Shetty Sudhakar ◽  
Chin Mui Jaime Seah ◽  
Pei Ting Tan ◽  
Su Ming Tan
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Disease Progression ◽  
Cancer Patients ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Breast Cancer Patients ◽  
Institutional Ethics ◽  
Estrogen Receptor Positivity ◽  
Progesterone Receptor Positivity

Abstract BackgroundDuctal carcinoma in situ (DCIS) is an established precursor to invasive ductal carcinoma (IDC) and its coexistence with IDC appear to favour reduced biological aggressiveness. Its prognostic implication and ability to affect clinical outcome has been understudied in Asia. This study aims to explore if concomitant DCIS affects the clinical behavior and outcomes among Asians. MethodsStage I to III breast cancer patients with histologically proven invasive ductal carcinoma, diagnosed and treated in a single institution from 1 June 2004 to 30 June 2014 were included in this study. Statistical analyses were conducted using x2 test, independent T- test, multi-variate logistic regression and Kaplan- Meier test.ResultsA total of 818 patients were identified, including 224 and 594 patients with isolated IDC (No-DCIS) and IDC with coexisting DCIS (IDC-DCIS) respectively. Patients with IDC-DCIS were found to have smaller tumours (median: 22mm, p<=0.01), estrogen receptor positivity (p=0.001), progesterone receptor positivity (p<0.001) and associated with better pathological stage (p=0.001). Patients with No-DCIS were 1.6 times more likely to develop disease progression (95% CI: 1.1- 2.3, p=0.027) and subsequently associated with distant recurrences (20.5% vs 13.6%, p=0.02). The breast cancer specific 5 year overall survival rate for patients with No-DCIS and those with IDC-DCIS was 90.9% (95% CI: 86.2% - 94.5%) and 93.7% (95% CI: 91.4- 95.5%) respectively (p=0.202).ConclusionThe presence of DCIS component in IDC among Asians is associated with favourable tumour biological profile, thereby indicating reduced disease aggressiveness. Our study is the first to report the clinical significance in terms of disease progression and distant recurrences among Asians. Trial registrationThis study had received the approval of the institutional ethics committee prior to its commencement (IRB Ref No: 2019/2884).

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