TRAIL Death Receptor–4 Expression Positively Correlates With the Tumor Grade in Breast Cancer Patients With Invasive Ductal Carcinoma

2007 ◽  
Vol 69 (3) ◽  
pp. 716-723 ◽  
Author(s):  
Ahter D. Sanlioglu ◽  
Aylin F. Korcum ◽  
Elif Pestereli ◽  
Gulgun Erdogan ◽  
Seyda Karaveli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Death Receptor ◽  
Tumor Grade ◽  
Breast Cancer Patients ◽  
Death Receptor 4 ◽  
Trail Death Receptor

scholarly journals Up-regulation of FOXN3-AS1 in invasive ductal carcinoma of breast cancer patients

Heliyon ◽  
2021 ◽  
Vol 7 (10) ◽  
pp. e08179
Author(s):  
Samira Molaei Ramshe ◽  
Hamid Ghaedi ◽  
Mir Davood Omrani ◽  
Lobat Geranpayeh ◽  
Behnam Alipour ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Breast Cancer Patients

scholarly journals Histopathologic Characteristics of Invasive and Non-invasive Ductal Tumors have Relationship with Different Phenotypes of ER / PR Receptors in Breast Cancer Patients

2021 ◽  
Vol 6 (3) ◽  
pp. 181-185
Author(s):  
Rahim Golmohammadi ◽  
Mohammad Reza Mohajeri ◽  
Alireza Mosavi Jarrahi ◽  
Ali Reza Moslem ◽  
Akbar Pejhan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Hormone Receptors ◽  
Ductal Carcinoma ◽  
Tumor Grade ◽  
Tumor Stage ◽  
Tumor Type ◽  
Breast Cancer Patients ◽  
Non Invasive ◽  
Significant Difference

Objective: Contradictory reports have been published regarding the expression levels of the hormone receptors of estrogen and progesterone (ER / PR) and theirclinical importance in diagnosis of breast cancer. The aim of this study was to evaluate the relationship between pathological features of invasive and non-invasive ductal tumors by different ER / PR phenotypes. Methods: This descriptive-analytical study was performed on 74 specimens of breast cancer referred to Isfahan Hospitals for diagnosis between 2015 - 2018. After fixation of the specimens in formalin, tissue passage, cross section and H / E staining, the specimens were divided into two groups: non- invasive and Invasive ductal Carcinoma. After removing of mask, expression of different ER / PR phenotypes was performed using primary monoclonal antibody and immunohistochemically methods. Results: From 74 malignant specimens, 61 (82.4%) were in the category of invasive ductal tumors and 13 cases (17.6%) were in the category of non-invasive ductal tumors. Out of 73 patients with positive ER or PR phenotype 47 samples (63.5%) had ER + / PR +phenotypes, 6 samples had (8.1%) ER+ / PR –phenotype, 20 samples (27%) had ER- / PR + phenotype and only one sample (1.4%) had the ER- / PR- phenotype and was in the category of invasive ductal tumors. There was not detected ER- / PR- phenotype expression in non-invasive ductal tumor. Further analysis showed that there were not significant difference between ER / PR phenotype and tumor stage (p =0.36) or with tumor Grade (P=0.38), high age of menopause or post menopause (P> 0.05). Conclusion: Our data shows that expression of ER- / PR- phenotype only was detected in invasive ductal tumor. It is thought that the tumor type maybe affects the expression of different types of ER / PR hormone receptor phenotypes in breast cancer patients.

scholarly journals MMP-2 levels evaluation and their relationship with breast cancer progression.

2020 ◽  
Vol 27 (02) ◽  
pp. 424-430
Author(s):  
Ifrah Yaqoob ◽  
Muhammad Saeed ◽  
Aysha Azhar
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Invasive Ductal Carcinoma ◽  
Cancer Progression ◽  
Ductal Carcinoma ◽  
Histological Type ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
The University

Matrix metalloproteinases (MMPs) play significant part in the tumor development, metastasis and invasion by proteolytic degradation of basement membrane and extracellular matrix. Hence MMPs can serve as good biomarkers for carcinoma breast particularly MMP-2 in our population. Objectives: To measure the concentrations of MMP-2 in plasma of breast cancer patients and establishing their correlation with stage and grade of the disease. Study Design: Comparative cross sectional. Setting: Surgery department Madinah Teaching Hospital (MTH) and the Pathology department, The University of Faisalabad (TUF), Faisalabad. Period: 1st August, 2017 to 31st December, 2017. Material & Methods: Only females with diagnosed breast cancer disease along with staging and grading were included in the study. Females with incomplete reports, on chemotherapy or radiotherapy or having other diseases like oral squamous cell carcinoma, rheumatoid arthritis etc were excluded. ELISA kit was applied to measure the concentrations of MMP-2 in plasma of the participants. OD values were calculated at 450 nm by ELISA reader placed at Post Graduate Research Laboratory, The University of Faisalabad, Faisalabad. Data was gathered and results were finalized by using SPSS 22 for statistical assessment. Results: Age of 64(72%) breast cancer patients was within range of 30-76yrs and age for 25(28%) healthy females as controls range was 18-70yrs. Difference between ages of cases and controls using t-test was statistically highly significant. Ninety five percent cases showed invasive ductal carcinoma (IDC) as histological type. Range of MMP-2 levels in cases was 80-690 ng/mL with mean 451.02 while range of MMP-2 levels in controls was 65-830ng/mL with mean 329.72 showing statistically significant difference. Relationship of different groups of MMP-2 levels in cases with stages of breast cancer was established using chi-square test which was statistically significant, stage IIB (37.5%) and IIIA (34.4%) tumors showed higher values of MMP-2. Relationship between MMP-2 levels, grade, tumor size and node invasion was nonsignificant statistically. Conclusion: MMP-2 levels were raised in cases in comparison to healthy controls. Age of majority patients was > 45 yrs while the invasive ductal carcinoma was the main histological type. MMP-2 levels were associated with stage of the disease.

scholarly journals Variation of Tumour Size Measurements Between Radiology and Pathology

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Breast Cancer ◽  
Retrospective Study ◽  
Breast Carcinoma ◽  
Cancer Patients ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Tumour Size ◽  
Breast Cancer Patients ◽  
Management Planning ◽  
Radiology And Pathology

The aim of this study is to determine the accuracy of the preoperative measurement of tumour size, by imaging modalities and whether they deviate from the postoperative pathological measurement in breast cancer. Material and methods: retrospective study done at King Fahad Hospital of University. For two years 2014-2015 all breast cancer patients included studied by reviewing US which was reported by two radiologists and gross size reports by five pathologists. The correlation of ultrasound, with pathology was studied. Results: 118 cases were collected from January 2014 to December 2015 with diagnosis of breast carcinoma. 36 patients were excluded from the study. Finally, a total of 82 were included in the analysis. Invasive ductal carcinoma (IDC) found in 57 patients (69.5%), 44 patients (53.7%) underwent breast conserving surgeries. 46 patient (56.1%) found to be either over or underestimated by US or Pathology. Conclusion: Despite the importance of accuracy of tumour size in management planning this study reflect marked discrepancy in sizes. More collaboration between radiologist and pathologist will yield accurate measurement, which will impact positively on outcome.

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