scholarly journals The Beneficial Effects of Cardiac Rehabilitation on the Function and Levels of Endothelial Progenitor Cells

2017 ◽  
Vol 26 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Yuan Guo ◽  
Robert Andre Ledesma ◽  
Ran Peng ◽  
Qiong Liu ◽  
Danyan Xu
Keyword(s):  
Cardiac Rehabilitation ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Beneficial Effects

A cardiac rehabilitation program increases the acute respond of endothelial progenitor cells after maximum exercise in patients with chronic heart failure

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C Kourek ◽  
E Karatzanos ◽  
D Delis ◽  
M Alshamari ◽  
V Linardatou ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Exercise Training ◽  
Cardiac Rehabilitation ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Rehabilitation Program ◽  
Vascular Endothelial ◽  
Endothelial Progenitor ◽  
Maximum Exercise

Abstract Background Chronic heart failure (CHF) remains a leading cause of morbidity and mortality and it is characterized by vascular endothelial dysfunction. During the last decades, endothelial progenitor cells (EPCs) are being used as an index of the endothelium restoration potential, therefore reflecting the vascular endothelial function. Exercise training has been shown to stimulate the mobilization of EPCs at rest in CHF patients. However, the effect of exercise training on the acute respond of EPCs after maximum exercise in CHF patients remains unknown. Purpose The purpose of the study was to assess the effect of a cardiac rehabilitation (CR) program on the acute respond of EPCs after maximum exercise in patients with CHF. Methods Forty-four consecutive patients (35 males) with stable CHF [mean±SD, Age (years): 56±10, BMI (kg/m2): 28.7±5.2, EF (%): 33±8, Peak VO2 (ml/kg/min): 18.4±4.4, Peak work rate (watts): 101±39] enrolled a 36-session CR program based on high-intensity interval exercise training. All patients underwent an initial symptom limited maximal cardiopulmonary exercise testing (CPET) on an ergometer before the CR program and a final maximal CPET after the CR program. Venous blood was drawn before and after each CPET. Five circulating endothelial populations were identified and quantified by flow cytometry; CD34+/CD45-/CD133+, CD34+/CD45-/CD133+/VEGFR2, CD34+/CD133+/VEGFR2, CD34+/CD45-/CD133- and CD34+/CD45-/CD133-/VEGFR2. EPCs values are expressed as cells/million enucleated cells in medians (25th-75th percentiles). Results The acute mobilization of EPCs after the final CPET was higher than after the initial CPET in 4 out of 5 circulating endothelial populations. Most specifically, difference of the acute mobilization of CD34+/CD45-/CD133+ cells [initial CPET: 25 (15–46) vs final CPET: 49 (26–71), p=0.002], CD34+/CD45-/CD133+/VEGFR2 cells [initial CPET: 3 (2–5) vs final CPET: 8 (5–12), p<0.001], CD34+/CD45-/CD133- cells [initial CPET: 129 (52–338) vs final CPET: 250 (129–518), p=0.03] and CD34+/CD45-/CD133-/VEGFR2 cells [initial CPET: 2 (1–4) vs final CPET: 6 (3–9), p<0.001] increased after the final CPET. The acute mobilization of CD34+/CD133+/VEGFR2 cells [initial CPET: 3 (−1–7) vs final CPET: 5 (0–15), p=0.441] did not differ between the 2 CPETS. Conclusion A 36-session cardiac rehabilitation program increases the acute respond of endothelial progenitor cells after maximum cardiopulmonary exercise training in patients with chronic heart failure, therefore indicating the beneficial effect of exercise training on the vascular endothelial function. Funding Acknowledgement Type of funding source: Public grant(s) – EU funding. Main funding source(s): Co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Programme “Human Resources Development, Education and Lifelong Learning” in the context of the project

Adherence to lifestyle modifications after a cardiac rehabilitation program and endothelial progenitor cells

2014 ◽  
Vol 112 (07) ◽  
pp. 196-204 ◽  
Author(s):  
Rossella Marcucci ◽  
Anna Gori ◽  
Costanza Burgisser ◽  
Sara Francini ◽  
Anna Roberts ◽  
...  
Keyword(s):  
Cardiac Rehabilitation ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Exercise Capacity ◽  
Dietary Habits ◽  
Rehabilitation Program ◽  
Lifestyle Modifications ◽  
Endothelial Progenitor ◽  
Lifestyle Recommendations ◽  
The Impact

SummaryAn increase of endothelial progenitor cells (EPCs) among acute myo-cardial infarction (AMI) patients participating in a cardiac rehabilitation (CR) program has been reported, but no data on the impact of adherence to lifestyle recommendations provided during a CR program on EPCs are available. It was our aim to investigate the effect of adherence to lifestyle recommendations on EPCs, inflammatory and functional parameters after six months of a CR program in AMI patients. In 110 AMI patients (90 male/20 female; mean age 57.9 ± 9.4 years) EPCs, high sensitivity C-reactive protein (hsCRP), N-terminal pro-brain natriuretic peptide (NT-ProBNP) levels, and cardiopulmonary testings were determined at the end of the CR (T1) and at a six-month follow-up (T2). At T2 we administered a questionnaire assessing dietary habits and physical activity. At T2, we observed a decrease of EPCs (p<0.05), of hsCRP (p=0.009) and of NT-ProBNP (p<0.0001). Patient population was divided into three categories by Healthy Lifestyle (HL) score (none/low, moderate and high adherence to lifestyle recommendations). We observed a significant association between adherence to lifestyle recommendations, increase in EPCs and exercise capacity between T1 and T2 (Δ EPCs p for trend <0.05; ΔWatt max p for trend=0.004). In a multivariate logistic regression analyses, being in the highest tertile of HL score affected the likelihood of an increase of EPC levels at T2 [OR (95% confidence interval): 3.36 (1.0–10.72) p=0.04]. In conclusion, adherence to lifestyle recommendations provided during a CR program positively influences EPC levels and exercise capacity.

Abstract 3752: Mineralocorticoid Receptor Antagonism Prevents Aldosterone Mediated Dysfunction of Human Endothelial Progenitor Cells in Vitro, in Vivo and in Patients

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Thomas Thum ◽  
Kerstin Schmitter ◽  
Daniela Fraccarollo ◽  
Julian Widder ◽  
Ertl Georg ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Mineralocorticoid Receptor ◽  
Endothelial Progenitor ◽  
Peripheral Arterial Tonometry ◽  
Genetic Ablation ◽  
Beneficial Effects

Hyperaldosteronism has been associated with vascular injury. Bone marrow derived endothelial progenitor cells (EPC) play an important role in endothelial repair and vascular homeostasis. We therefore examined the effects of aldosterone and its blockade by the mineralocorticoid receptor (MR) antagonist eplerenone on EPC number and function in vitro , in vivo and a clinical trial . EPCs expressed the MR at the gene and protein level. Aldosterone treatment of human EPC led to a translocation of the MR into the nucleus and impaired multiple cellular functions, such as differentiation, migration, proliferation and incorporation in vascular networks. Impaired EPC function was rescued by pharmacological antagonism or genetic ablation of the MR. Aldosterone increased the intracellular production of reactive oxygen species (ROS), which was attenuated by MR blockade. Aldosterone-mediated increase of ROS was mainly protein kinase A-dependent and resulted in cAMP activation with subsequent impairment of EPC migration. Chronic aldosterone infusion in mice (implanted minipumps, 50mg/kg/d for 14d) impaired EPC functionality and resulted in endothelial dysfunction. MR antagonism prevented those effects. In patients with hyperaldosteronism, EPC displayed reduced migratory potential compared with age-matched healthy controls. Impaired function of EPC from patients with hyperaldosteronism significantly correlated with endothelial dysfunction assessed by peripheral arterial tonometry. Importantly, MR antagonism in patients with hyperaldosteronism improved EPC as well as endothelial function. EPC function is impaired in hyperaldosteronism by increased intracellular ROS production and cAMP activation. Beneficial effects of MR antagonists in cardiovascular disease prevention and therapy especially during hyperaldosteronism may be mediated in part by improved EPC biology.

Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease

2011 ◽  
Vol 111 (1) ◽  
pp. 321-328 ◽  
Author(s):  
Karsten Lenk ◽  
Madlen Uhlemann ◽  
Gerhard Schuler ◽  
Volker Adams
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Physical Exercise ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Beneficial Effects ◽  
Endothelial Cell Layer ◽  
Artery Disease

In clinical trials as well as in several animal experiments it is evident that physical exercise is a powerful tool to positively influence the development and/or progression of atherosclerosis and coronary artery disease (CAD). The main target of physical exercise seems to be the maintenance of an intact endothelial cell layer. Since the discovery that endothelial progenitor cells (EPCs) are present in the circulation and the knowledge that exercise, either as a single exercise bout or an exercise training program, have the potency to mobilize EPCs from the bone marrow, the contribution of the EPCs for the preservation or repair of the endothelial cell layer is still under debate. Either the EPCs differentiate into mature endothelial cells, or they stimulate via a paracrine mechanism mature endothelial cells to proliferate. It is still unclear, if the exercise-induced mobilization of EPCs is casually related to the improvement of endothelial function. This review will discuss the role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease.

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