The Relationship Between Serum Zinc Levels, Cardiac Markers and the Risk of Acute Myocardial Infarction by Zinc Quartiles

We looked at the relationship between linear growth retardation and deficiencies of certain nutrients in Egyptian children. A group of 107 stunted children aged between 10 and 18 years were subjected to history-taking, physical examination and laboratory investigations. Selected cases were referred to radiology for assessment of bone age. Thirty-nine children were enrolled as controls. Serum haemoglobin, alpha-tocopherol, retinol and magnesium levels were significantly decreased in stunted children compared with the controls. Serum zinc levels were also lower in the stunted group but not significantly so. We conclude that several nutrient deficiencies occur simultaneously in stunted children and all of them may be responsible for stunting.

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Serum Zinc Levels and in Vivo Beta-Amyloid Deposition in the Human Brain

10.21203/rs.3.rs-705022/v1 ◽

2021 ◽

Author(s):

Jee Wook Kim ◽

Min Soo Byun ◽

Dahyun Yi ◽

Jun Ho Lee ◽

Min Jung Kim ◽

...

Keyword(s):

Serum Zinc ◽

Beta Amyloid ◽

Zinc Level ◽

Amyloid Deposition ◽

Serum Zinc Level ◽

Positron Emission ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

Abstract Background: Despite the known associations between zinc levels and Alzheimer’s disease (AD) dementia and related cognitive impairment, the underlying neuropathological links remain poorly understood. We tested the hypothesis that serum zinc level is associated with cerebral beta-amyloid protein (Ab) deposition. Additionally, we explored associations between serum zinc levels and other AD pathologies [i.e., tau deposition and AD-signature cerebral glucose metabolism (AD-CM)] and white matter hyperintensities (WMHs), which are measures of cerebrovascular injury. Methods: A total of 241 cognitively normal older adults between 55 and 90 years of age were enrolled. All the participants underwent comprehensive clinical assessments, serum zinc level measurement, and multimodal brain imaging, including Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, fluorodeoxyglucose (FDG)-PET, and magnetic resonance imaging. Zinc levels were stratified into three categories: < 80 µg/dL (low), 80 to 90 µg/dL (medium), and > 90 µg/dL (high). Results: A low serum zinc level was significantly associated with increased Ab retention. In addition, apolipoprotein E ε4 allele (APOE4) status moderated the association: the relationship between low zinc level and Ab retention was significant only in APOE4 carriers. Although a low zinc level appeared to reduce AD-CM, the relationship became insignificant on sensitivity analysis including only individuals with no nutritional deficiency. The serum zinc level was associated with neither tau deposition nor the WMH volume. Conclusions: Our findings suggest that decreased serum zinc levels are associated with elevation of brain amyloid deposition. In terms of AD prevention, more attention needs to be paid to the role of zinc.

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Investigation of the Relationship Between Ischemic Stroke Disease and Serum Zinc Levels

Erciyes Medical Journal ◽

10.14744/etd.2021.35589 ◽

2021 ◽

Author(s):

Nevra Alkanli

Keyword(s):

Ischemic Stroke ◽

Serum Zinc ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

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The relationship between serum zinc levels and rheumatoid arthritis activity

Frontiers in Biology ◽

10.1007/s11515-017-1474-y ◽

2018 ◽

Vol 13 (1) ◽

pp. 51-55

Author(s):

Elham Rajaee ◽

Karim Mowla ◽

Ali Ghorbani ◽

Mehrdad Dargahi-Malamir ◽

Marzieh Zarei ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Serum Zinc ◽

Zinc Levels ◽

The Relationship ◽

Rheumatoid Arthritis Activity ◽

Serum Zinc Levels

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Low Serum Zinc Level May be Related to Higher Doses of EPO in Hemodialysis Patients

BANTAO Journal ◽

10.2478/bj-2014-0009 ◽

2015 ◽

Vol 12 (1) ◽

pp. 40-44

Author(s):

Itir Yegenaga ◽

Zeki Aydin

Keyword(s):

Serum Zinc ◽

Zinc Level ◽

Control Group ◽

Inadequate Response ◽

Recombinant Erythropoietin ◽

Serum Zinc Level ◽

Human Recombinant Erythropoietin ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

AbstractIntroduction.Anemia is a complication of chronic renal failure observed in patients on hemodialysis (HD) affecting morbidity and mortality of these patients. It is associated with erythropoietin (EPO) deficiency and can be treated by human recombinant erythropoietin (hrEPO). Iron deficiency has been reported as the first line cause for inadequate response to this treatment. Zinc deficiency in hemodialysis (HD) patients was previously reported and the relationship between iron and zinc deficiencies has been known for years. The aim of this study was to find out the relationship between serum zinc level, anemia and rhEPO consuming in HD patients.Methods.A total of 69 HD patients and 34 healthy individuals were included in the study. Serum zinc levels, clinical, hematologic, biochemical parameters and rhEPO doses were evaluated.Results.Serum zinc levels were found to be lower in HD patients in comparison to those in the control group (29.92±12.94, 44.82±27.69μg/dL, respectively) (p<0.001). There was a positive correlation between serum zinc and hemoglobin (Hb) in the control group (R2=0.06). In HD patients who needed less then 8000U/week rhEPO, Hb levels (p<0.05) and serum zinc levels were higher. Serum zinc and Hb levels were found to be higher in patients who were under HD treatment for more than 12 months (10.05±1.06 vs 10.69±1.29; p=0.022 and 26.96±13.29 vs 30.88±12.61; p=0.178).Conclusions.HD patients who needed lower dose of EPO had higher serum zinc levels. Although the difference was not statistically significant, these results provide evidence that serum zinc level should be taken into consideration especially in HD patients resistant to EPO therapy.

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SMALL BABIES

The Professional Medical Journal ◽

10.29309/tpmj/2005.12.03.5133 ◽

2005 ◽

Vol 12 (03) ◽

pp. 336-339

Author(s):

MUHAMMAD ASHRAF ◽

Zamir Ahmad ◽

MUHAMMAD NASARULLAH KHAN ◽

Tariq Ferroz Khawaja ◽

MUHAMMAD AYUB KHAN ◽

...

Keyword(s):

Dna Polymerase ◽

Gestational Age ◽

Serum Zinc ◽

Maternal Serum ◽

Maternal Complications ◽

Metallic Component ◽

Zinc Levels ◽

Relationship Of ◽

The Relationship ◽

Serum Zinc Levels

Zinc is an essential trace mineral. It is considered a growth factor as it isthe metallic component of enzymes DNA polymerase, DNA dependent RNA polymerase and thymidine kinase.Objective: To find out the relationship of maternal serum zinc levels with birth weight of the babies. Period: January1989 to May, 1991. Setting: Lady Wellingdon Hospital Lahore, King Edward College, Lahore and MetallurgyDepartment PCSIR Laboratories, Lahore. Design: Prospective study Patients & methods: Among the 216 registeredpregnant women 46 subjects had no feto-maternal complications during pregnancy and they delivered babies havingbirth weight adequate for Gestational Age (AGA). Thirteen women gave birth to babies Small for Gestational Age(SGA). Blood samples were taken at the end of each trimester and serum zinc was measured by atomic absorptionspectrophotometer. Results: Serum zinc levels were significantly low (P<0.001) throughout pregnancy in women givingbirth to SGA babies. Conclusion: Serum zinc levels throughout the course of pregnancy are associated with intrauterinegrowth of the babies.b

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The Relationship Between Serum Zinc Levels and Tumor Markers in Hemodialysis Patients

Electronic Journal of General Medicine ◽

10.15197/sabad.1.11.65 ◽

2014 ◽

Vol 11 (3) ◽

Cited By ~ 1

Author(s):

Kultigin Turkmen ◽

Tevfik Ecder ◽

Suleyman Turk

Keyword(s):

Tumor Markers ◽

Serum Zinc ◽

Hemodialysis Patients ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

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Association between Serum Zinc and hs-CRP Concentrations in Different Metabolic Syndrome Phenotypes

10.21203/rs.3.rs-727387/v1 ◽

2021 ◽

Author(s):

Susan Darroudi ◽

Batool Tayefi ◽

Habibollah Esmaily ◽

Fatemeh Sadabadi ◽

Hamideh Moalemzadeh Haghighi ◽

...

Keyword(s):

Metabolic Syndrome ◽

Serum Zinc ◽

Heart Association ◽

Flame Atomic Absorption ◽

Increased Risk ◽

Serum Zn ◽

Hs Crp ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

Abstract Background: Metabolic syndrome (MetS) is associated with an increased risk of cardiovascular disease and all-cause mortality. Zinc (Zn) is an essential trace element for the synthesis, storage, and release of insulin. The relationship between serum Zn and MetS is controversial. In this study we have evaluated whether serum Zn levels are associated with hsCRP level according to MetS phenotypes. Method: A total of 9493 individuals (3768 men and 5635 women) were recruited as part of the Mashhad Stroke and Heart Association Disorder (MASHAD) study. We measured the concentration of serum Zn by flame atomic absorption (Varian AA240FS) and we divided the subjects into quartile of serum Zn. We used SPSS version 18 statistical analyses for all. GraphPad Prism 6 for figures was used.Results: In this study there were significant differences between quartiles of Zn according to sex. The results showed that the level of serum hs-CRP were higher in subjects with metabolic syndrome who also had a serum Zn >95 µg/dl. In subjects with serum Zn <70 µg/dl, an increase in serum hs-CRP was associated with an increased risk of MetS by 2.2%, 1.022(CI: 1.01-1.034). Moreover, among subjects in the first, second and third quartiles of serum Zn, some phenotypes of metabolic syndrome (WHB, WHT, WTG, WTB, WHBG, WHTG, and WTBG) were associated with a risk of increasing hs-CRP level (p< 0.05). Conclusion: Serum hs-CRP concentrations were related to MetS phenotypes. This relationship was modified by serum Zn level. According to the number of MetS components serum Zn levels decreased as the number of MetS component increased, and low serum zinc levels (Q1) showed an overall greater prevalence of MetS.

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Serum zinc level: a prognostic marker for severe pneumonia in children

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20190435 ◽

2019 ◽

Vol 6 (2) ◽

pp. 406

Author(s):

I. Abhiram ◽

Suresh Panchanathan ◽

Rajaguru Ganesan ◽

Antony Jenifer

Keyword(s):

Statistical Significance ◽

Serum Zinc ◽

Severe Pneumonia ◽

Zinc Level ◽

Early Recovery ◽

Study Population ◽

Group 2 ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

Background: Pneumonia is one of the leading causes of under 5 mortality among children in developing countries. Zinc deficiency is postulated as cause of severe pneumonia, but evidences shows conflicting results on whether serum zinc levels predicts the severity of pneumonia. So prospective study was undertaken to study the relationship between serum zinc levels and severity of pneumonia in children with community acquired pneumonia.Methods: Fifty cases of pneumonia (group 1) and 50 cases of severe pneumonia (group 2) according to WHO classification were enrolled into the study. Demography, anthropometry and immunization status were recorded. A single zinc measurement was performed for all the patients within 24 hours of admission. The severity, clinical course including recovery to discharge was compared between two groups with respect to their serum zinc levels.Results: Mean (±SD) age group of the study population was 22 months±16.05 and 21.88 months±15.97 months in boys and girls respectively. Pneumonia was high in girls (59%) and children between 2 to <12 months had higher (36%) infection rate. Mean zinc level in pneumonia and severe pneumonia group were 68.69µg/dl±28.77 and 68.08µg/dl±27.55 respectively. There was no difference in the nutritional status (weight for height and height for age) of the study group. Serum Zn level was low in 56 % and 52% of pneumonia and severe pneumonia group respectively. Comparison of serum zinc levels between the ARTI groups did not achieve statistical significance (p=0.430). However, the duration of recovery is earlier than 1 week in pneumonia cases when compared to severe pneumonia patients (p<0.001, OR 1.375).Conclusions: Normal zinc levels was associated with early recovery in simple pneumonia patient, so study of serum zinc levels in severe pneumonia patients has prognostic value.

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