scholarly journals Association between Serum Zinc and hs-CRP Concentrations in Different Metabolic Syndrome Phenotypes

2021 ◽  
Author(s):  
Susan Darroudi ◽  
Batool Tayefi ◽  
Habibollah Esmaily ◽  
Fatemeh Sadabadi ◽  
Hamideh Moalemzadeh Haghighi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Serum Zinc ◽  
Heart Association ◽  
Flame Atomic Absorption ◽  
Increased Risk ◽  
Serum Zn ◽  
Hs Crp ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

Abstract Background: Metabolic syndrome (MetS) is associated with an increased risk of cardiovascular disease and all-cause mortality. Zinc (Zn) is an essential trace element for the synthesis, storage, and release of insulin. The relationship between serum Zn and MetS is controversial. In this study we have evaluated whether serum Zn levels are associated with hsCRP level according to MetS phenotypes. Method: A total of 9493 individuals (3768 men and 5635 women) were recruited as part of the Mashhad Stroke and Heart Association Disorder (MASHAD) study. We measured the concentration of serum Zn by flame atomic absorption (Varian AA240FS) and we divided the subjects into quartile of serum Zn. We used SPSS version 18 statistical analyses for all. GraphPad Prism 6 for figures was used.Results: In this study there were significant differences between quartiles of Zn according to sex. The results showed that the level of serum hs-CRP were higher in subjects with metabolic syndrome who also had a serum Zn >95 µg/dl. In subjects with serum Zn <70 µg/dl, an increase in serum hs-CRP was associated with an increased risk of MetS by 2.2%, 1.022(CI: 1.01-1.034). Moreover, among subjects in the first, second and third quartiles of serum Zn, some phenotypes of metabolic syndrome (WHB, WHT, WTG, WTB, WHBG, WHTG, and WTBG) were associated with a risk of increasing hs-CRP level (p< 0.05). Conclusion: Serum hs-CRP concentrations were related to MetS phenotypes. This relationship was modified by serum Zn level. According to the number of MetS components serum Zn levels decreased as the number of MetS component increased, and low serum zinc levels (Q1) showed an overall greater prevalence of MetS.

Levels of Serum Zinc and Manganese among Post-Menopausal Patients with Thyroid Dysfunction

2016 ◽  
Vol 5 (02) ◽  
pp. 4821
Author(s):  
Sharique Ahmad* ◽  
Saeeda Wasim
Keyword(s):  
Thyroid Dysfunction ◽  
Serum Zinc ◽  
Flame Atomic Absorption ◽  
Flame Atomic Absorption Spectrophotometer ◽  
Serum Zn ◽  
Zinc Levels ◽  
Post Menopausal ◽  
Manganese Level ◽  
Serum Zinc Levels

The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism and hypothyroidism in Post-Menopausal Patients. The content of the trace elements Zinc and Manganese (Zn, and Mn) in the serum of patients was determined. Forty patients with hyperthyroidism and hypothyroidism were participated in this study. Serum zinc and manganese were determined using flame atomic absorption spectrophotometer technique. The study showed that serum zinc and manganese levels of hyperthyroidism patients were significantly lower (p<0.05). While a significant increase in serum manganese level with decrease serum zinc levels in patients with hypothyroidism (p<0.05).  The present study confirmed a significant change in the levels of serum Zn, Mn in hyperthyroidism and hypothyroidism among Post-Menopausal patients and these changes may be related to pathophysiology of thyroid disease.

scholarly journals Nutritional stunting in Egypt: which nutrient is responsible?

2002 ◽  
Vol 8 (2-3) ◽  
pp. 272-280
Author(s):  
S. A. Ibrahim ◽  
A. Abdel Maksoud ◽  
M. F. Nassar
Keyword(s):  
Linear Growth ◽  
Serum Zinc ◽  
Bone Age ◽  
Alpha Tocopherol ◽  
Nutrient Deficiencies ◽  
Egyptian Children ◽  
Laboratory Investigations ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

We looked at the relationship between linear growth retardation and deficiencies of certain nutrients in Egyptian children. A group of 107 stunted children aged between 10 and 18 years were subjected to history-taking, physical examination and laboratory investigations. Selected cases were referred to radiology for assessment of bone age. Thirty-nine children were enrolled as controls. Serum haemoglobin, alpha-tocopherol, retinol and magnesium levels were significantly decreased in stunted children compared with the controls. Serum zinc levels were also lower in the stunted group but not significantly so. We conclude that several nutrient deficiencies occur simultaneously in stunted children and all of them may be responsible for stunting.

scholarly journals Serum Zinc Levels and in Vivo Beta-Amyloid Deposition in the Human Brain

2021 ◽  
Author(s):  
Jee Wook Kim ◽  
Min Soo Byun ◽  
Dahyun Yi ◽  
Jun Ho Lee ◽  
Min Jung Kim ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Beta Amyloid ◽  
Zinc Level ◽  
Amyloid Deposition ◽  
Serum Zinc Level ◽  
Positron Emission ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

Abstract Background: Despite the known associations between zinc levels and Alzheimer’s disease (AD) dementia and related cognitive impairment, the underlying neuropathological links remain poorly understood. We tested the hypothesis that serum zinc level is associated with cerebral beta-amyloid protein (Ab) deposition. Additionally, we explored associations between serum zinc levels and other AD pathologies [i.e., tau deposition and AD-signature cerebral glucose metabolism (AD-CM)] and white matter hyperintensities (WMHs), which are measures of cerebrovascular injury. Methods: A total of 241 cognitively normal older adults between 55 and 90 years of age were enrolled. All the participants underwent comprehensive clinical assessments, serum zinc level measurement, and multimodal brain imaging, including Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, fluorodeoxyglucose (FDG)-PET, and magnetic resonance imaging. Zinc levels were stratified into three categories: < 80 µg/dL (low), 80 to 90 µg/dL (medium), and > 90 µg/dL (high). Results: A low serum zinc level was significantly associated with increased Ab retention. In addition, apolipoprotein E ε4 allele (APOE4) status moderated the association: the relationship between low zinc level and Ab retention was significant only in APOE4 carriers. Although a low zinc level appeared to reduce AD-CM, the relationship became insignificant on sensitivity analysis including only individuals with no nutritional deficiency. The serum zinc level was associated with neither tau deposition nor the WMH volume. Conclusions: Our findings suggest that decreased serum zinc levels are associated with elevation of brain amyloid deposition. In terms of AD prevention, more attention needs to be paid to the role of zinc.

scholarly journals Zinc Intake, Zinc Serum Levels, and Intelligence in School Children in Rural Areas

2021 ◽  
Vol 9 (E) ◽  
pp. 394-397
Author(s):  
Rostika Flora ◽  
Nur Alam Fajar ◽  
Fatmalina Febri ◽  
Indah Yuliana ◽  
Yuliarti Yuliarti ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
School Children ◽  
Significant Relationship ◽  
Rural Areas ◽  
Serum Zinc ◽  
Zinc Intake ◽  
Serum Zn ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Low Serum

BACKGROUND: Children in rural areas are susceptible to zinc deficiency. Zinc deficiency in children can affect cognitive function in children. Zinc plays a role in cellular function and critical brain growth processes, including cell replication, DNA and RNA synthesis, and the release of neurotransmitters. AIM: This study aimed to analyze the condition of zinc deficiency and its relationship with the level of intelligence in children in rural areas. METHODS: The study design was cross-sectional, with a sample of 44 elementary school children aged 9–12 years taken randomly. Blood was drawn to measure serum Zn-levels, and serum Zn-levels were measured using Colorimetric Assay Kit (E-BC-K137). Zinc intake data were obtained from the food recall form, which was carried out 3 × 24 h. The level of intelligence is measured by the Culture Fair Intelligence Test method. The sample characteristics data obtained through a questionnaire. Furthermore, the data were analyzed using the Chi-square test. RESULTS: About 84.2% of children with insufficient zinc intake had low serum Zn-levels. There was a significant relationship between zinc intake and serum zinc levels (p = 0.026; PR = 4.293). Children with low serum zinc levels of 96.5% have intelligence levels below average. There was a significant relationship between serum zinc levels and intelligence level as well (p = 0.001; PR = 24,500). CONCLUSION: Zinc deficiency in children is characterized by low serum Zn-levels. Low serum Zn-level is caused by low zinc intake, thus children with low serum Zn-levels are at risk of having intelligence level below average. Therefore, health education about the importance of zinc intake in children should be given to parents, so that the incidence of zinc deficiency in children can be reduced.

The relationship between serum zinc levels and rheumatoid arthritis activity

2018 ◽  
Vol 13 (1) ◽  
pp. 51-55
Author(s):  
Elham Rajaee ◽  
Karim Mowla ◽  
Ali Ghorbani ◽  
Mehrdad Dargahi-Malamir ◽  
Marzieh Zarei ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Zinc ◽  
Zinc Levels ◽  
The Relationship ◽  
Rheumatoid Arthritis Activity ◽  
Serum Zinc Levels

scholarly journals Changes in Serum Zinc Levels in Relation to Blood Pressure During Anaesthesia

2003 ◽  
Vol 40 (138) ◽  
pp. 67-71
Author(s):  
H K Garg ◽  
P Agrawal ◽  
S Haleem
Keyword(s):  
Venous Blood ◽  
Serum Zinc ◽  
Study Groups ◽  
Surgical Operation ◽  
Defence Mechanisms ◽  
Serum Zn ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Age And Sex ◽  
Maximum Rise

Fifty age and sex matched patients admitted for surgical operation, were divided intonormotensive (control) and hypertensive (study) groups. Systolic and diastolic bloodpressures were recorded preoperatively, 10 min after intubation, at max-increase ofBP and 24 hours postoperatively. 5 ml. venous blood samples were drawn at thesetime periods, and serum zinc was also estimated. Control Gp (normotensive) subjectrecorded fall (p < 0.001) in serum Zn 10 min after intubation (n = 18) and max. Riseof BP (n = 7), Twelve subjects in study Gp recorded a rise in serum Zn at max. Increaseof BP (p < 0.01). The pattern in normotensives points towards mobilization of zinc,while in hypertensives, homeostatic, defence mechanisms appear to resist mobilizationof serum Zn till maximum rise in BP occurs, indicating hormonal and other influenceson serum Zn levels during anaesthesia.Key Words: Serum Zinc, Systolic BP, Diastolic BP, Anaesthesia

scholarly journals Low Serum Zinc Level May be Related to Higher Doses of EPO in Hemodialysis Patients

2015 ◽  
Vol 12 (1) ◽  
pp. 40-44
Author(s):  
Itir Yegenaga ◽  
Zeki Aydin
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Inadequate Response ◽  
Recombinant Erythropoietin ◽  
Serum Zinc Level ◽  
Human Recombinant Erythropoietin ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

AbstractIntroduction.Anemia is a complication of chronic renal failure observed in patients on hemodialysis (HD) affecting morbidity and mortality of these patients. It is associated with erythropoietin (EPO) deficiency and can be treated by human recombinant erythropoietin (hrEPO). Iron deficiency has been reported as the first line cause for inadequate response to this treatment. Zinc deficiency in hemodialysis (HD) patients was previously reported and the relationship between iron and zinc deficiencies has been known for years. The aim of this study was to find out the relationship between serum zinc level, anemia and rhEPO consuming in HD patients.Methods.A total of 69 HD patients and 34 healthy individuals were included in the study. Serum zinc levels, clinical, hematologic, biochemical parameters and rhEPO doses were evaluated.Results.Serum zinc levels were found to be lower in HD patients in comparison to those in the control group (29.92±12.94, 44.82±27.69μg/dL, respectively) (p<0.001). There was a positive correlation between serum zinc and hemoglobin (Hb) in the control group (R2=0.06). In HD patients who needed less then 8000U/week rhEPO, Hb levels (p<0.05) and serum zinc levels were higher. Serum zinc and Hb levels were found to be higher in patients who were under HD treatment for more than 12 months (10.05±1.06 vs 10.69±1.29; p=0.022 and 26.96±13.29 vs 30.88±12.61; p=0.178).Conclusions.HD patients who needed lower dose of EPO had higher serum zinc levels. Although the difference was not statistically significant, these results provide evidence that serum zinc level should be taken into consideration especially in HD patients resistant to EPO therapy.

scholarly journals SMALL BABIES

2005 ◽  
Vol 12 (03) ◽  
pp. 336-339
Author(s):  
MUHAMMAD ASHRAF ◽  
Zamir Ahmad ◽  
MUHAMMAD NASARULLAH KHAN ◽  
Tariq Ferroz Khawaja ◽  
MUHAMMAD AYUB KHAN ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Gestational Age ◽  
Serum Zinc ◽  
Maternal Serum ◽  
Maternal Complications ◽  
Metallic Component ◽  
Zinc Levels ◽  
Relationship Of ◽  
The Relationship ◽  
Serum Zinc Levels

Zinc is an essential trace mineral. It is considered a growth factor as it isthe metallic component of enzymes DNA polymerase, DNA dependent RNA polymerase and thymidine kinase.Objective: To find out the relationship of maternal serum zinc levels with birth weight of the babies. Period: January1989 to May, 1991. Setting: Lady Wellingdon Hospital Lahore, King Edward College, Lahore and MetallurgyDepartment PCSIR Laboratories, Lahore. Design: Prospective study Patients & methods: Among the 216 registeredpregnant women 46 subjects had no feto-maternal complications during pregnancy and they delivered babies havingbirth weight adequate for Gestational Age (AGA). Thirteen women gave birth to babies Small for Gestational Age(SGA). Blood samples were taken at the end of each trimester and serum zinc was measured by atomic absorptionspectrophotometer. Results: Serum zinc levels were significantly low (P<0.001) throughout pregnancy in women givingbirth to SGA babies. Conclusion: Serum zinc levels throughout the course of pregnancy are associated with intrauterinegrowth of the babies.b

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