scholarly journals Patterns of chemotherapy for recurrent pancreatic cancer following resection: A population-level analysis

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e132
Author(s):  
E. Walser ◽  
D. Kagedan ◽  
C. Earle ◽  
Q. Li ◽  
L. Paszat ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Population Level ◽  
Recurrent Pancreatic Cancer ◽  
Level Analysis

scholarly journals Usefulness of Imaging Response Assessment after Irreversible Electroporation of Localized Pancreatic Cancer—Results from a Prospective Cohort

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2862
Author(s):  
Rasmus V. Flak ◽  
Rune V. Fisker ◽  
Niels H. Bruun ◽  
Mogens T. Stender ◽  
Ole Thorlacius-Ussing ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Irreversible Electroporation ◽  
Response Assessment ◽  
Time Intervals ◽  
Patient Level ◽  
Positron Emission ◽  
Included Patient ◽  
Before And After ◽  
Lesion Level ◽  
Level Analysis

(1) Background: Irreversible electroporation (IRE) is a nonthermal ablation technique that is being studied in nonmetastatic pancreatic cancer (PC). Most published studies use imaging outcomes as an efficacy endpoint, but imaging interpretation can be difficult and has yet to be correlated with survival. The aim of this study was to examine the correlation of imaging endpoints with survival in a cohort of IRE-treated PC patients. (2) Methods: Several imaging endpoints were examined before and after IRE on 18F-fluorodeoxyglucose positron emission tomography (PET) with computed tomography. Separate analyses were performed at the patient and lesion levels. Mortality rate (MR) ratios for imaging endpoints after IRE were estimated. (3) Results: Forty-one patients were included. Patient-level analysis revealed that progressive disease (PD), as defined by RECIST 1.1, is correlated with a higher MR at all time intervals, but PD, as defined by EORTC PET response criteria, is only correlated with the MR in the longest interval. No correlation was found between PD, as defined by RECIST, and the MR in the lesion-level analysis. (4) Conclusions: Patient-level PD, as defined by RECIST, was correlated with poorer survival after IRE ablation, whereas no correlations were observed in the lesion-level analyses. Several promising lesion-level outcomes were identified.

scholarly journals Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shannon Wongvibulsin ◽  
Nishadh Sutaria ◽  
Suraj Kannan ◽  
Martin Prince Alphonse ◽  
Micah Belzberg ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
African Americans ◽  
Immune Activation ◽  
Population Level ◽  
Research Network ◽  
Variation Analysis ◽  
Immune Signature ◽  
Key Drivers ◽  
Blood Eosinophils ◽  
Level Analysis

AbstractAtopic dermatitis (AD) often presents more severely in African Americans (AAs) and with greater involvement of extensor areas. To investigate immune signatures of AD in AAs with moderate to severe pruritus, lesional and non-lesional punch biopsies were taken from AA patients along with age-, race-, and sex-matched controls. Histology of lesional skin showed psoriasiform dermatitis and spongiotic dermatitis, suggesting both Th2 and Th17 activity. Gene Set Variation Analysis showed upregulation of Th2 and Th17 pathways in both lesional versus non-lesional and lesional versus control (p < 0.01), while Th1 and Th22 upregulation were observed in lesional versus control (p < 0.05). Evidence for a broad immune signature also was supported by upregulated Th1 and Th22 pathways, and clinically may represent greater severity of AD in AA. Furthermore, population-level analysis of data from TriNetX, a global federated health research network, revealed that AA AD patients had higher values for CRP, ferritin, and blood eosinophils compared to age-, sex-, and race-matched controls as well as white AD patients, suggesting broad systemic inflammation. Therefore, AA AD patients may feature broader immune activation than previously thought and may derive benefit from systemic immunomodulating therapies that modulate key drivers of multiple immune pathways.

Completion pancreatectomy for recurrent pancreatic cancer in the remnant pancreas: report of six cases and a review of the literature

2015 ◽  
Vol 400 (8) ◽  
pp. 973-978 ◽  
Author(s):  
Yasuo Shima ◽  
Takehiro Okabayashi ◽  
Akihito Kozuki ◽  
Tatsuaki Sumiyoshi ◽  
Teppei Tokumaru ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Review Of The Literature ◽  
Remnant Pancreas ◽  
Recurrent Pancreatic Cancer ◽  
Completion Pancreatectomy

Troubling Outcomes From Population-level Analysis of Surgery for Upper Tract Urothelial Carcinoma

Urology ◽  
2010 ◽  
Vol 76 (4) ◽  
pp. 895-901 ◽  
Author(s):  
Robert Abouassaly ◽  
Shabbir M.H. Alibhai ◽  
Nasir Shah ◽  
Narhari Timilshina ◽  
Neil Fleshner ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Population Level ◽  
Upper Tract Urothelial Carcinoma ◽  
Upper Tract ◽  
Level Analysis

scholarly journals Investigating hot-Jupiter inflated radii with hierarchical Bayesian modelling

2018 ◽  
Vol 616 ◽  
pp. A76 ◽  
Author(s):  
Marko Sestovic ◽  
Brice-Olivier Demory ◽  
Didier Queloz
Keyword(s):  
Large Fraction ◽  
Population Level ◽  
Mass Range ◽  
Hierarchical Bayesian ◽  
Incident Flux ◽  
Hot Jupiters ◽  
Probabilistic Relation ◽  
Relationship Of ◽  
The Relationship ◽  
Level Analysis

Context. As of today, hundreds of hot Jupiters have been found, yet the inflated radii of a large fraction of them remain unexplained. A number of mechanisms have been proposed to explain these anomalous radii, however most of these can only work under certain conditions and may not be sufficient to explain the most extreme cases. It is still unclear whether a single mechanism can sufficiently explain the entire distribution of radii, or whether a combination of these mechanisms is needed. Aims. We seek to understand the relationship of radius with stellar irradiation and mass and to find the range of masses over which hot Jupiters are inflated. We also aim to find the intrinsic physical scatter in their radii, caused by unobservable parameters, and to constrain the fraction of hot Jupiters that exhibit inflation. Methods. By constructing a hierarchical Bayesian model, we inferred the probabilistic relation between planet radius, mass, and incident flux for a sample of 286 gas giants. We separately incorporated the observational uncertainties of the data and the intrinsic physical scatter in the population. This allowed us to treat the intrinsic physical scatter in radii, due to latent parameters such as the heavy element fraction, as a parameter to be inferred. Results. We find that the planetary mass plays a key role in the inflation extent and that planets in the range ~0.37−0.98  MJ show the most inflated radii. At higher masses, the radius response to incident flux begins to decrease. Below a threshold of 0.37 ± 0.03  MJ we find that giant exoplanets as a population are unable to maintain inflated radii ≿1.4  RJ but instead exhibit smaller sizes as the incident flux is increased beyond 106 W m−2. We also find that below 1  MJ, there is a cut-off point at high incident flux beyond which we find no more inflated planets, and that this cut-off point decreases as the mass decreases. At incident fluxes higher than ~1.6 × 106 W m−2 and in a mass range 0.37−0.98  MJ, we find no evidence for a population of non-inflated hot Jupiters. Our study sheds a fresh light on one of the key questions in the field and demonstrates the importance of population-level analysis to grasp the underlying properties of exoplanets.

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