scholarly journals Repeated Surgical Resection of Recurrent Tumor after Initial Hepatectomy for Intrahepatic Cholangiocarcinoma

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S25
Author(s):  
J. Arita ◽  
A. Ichida ◽  
Y. Kawaguchi ◽  
T. Ishizawa ◽  
N. Akamatsu ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Recurrent Tumor ◽  
Initial Hepatectomy

scholarly journals Efficacy of surgical resection in patients with recurrent tumor of intrahepatic cholangiocarcinoma

2019 ◽  
Vol 30 ◽  
pp. iv49
Author(s):  
J. Arita ◽  
T. Ishizawa ◽  
N. Akamatsu ◽  
J. Kaneko ◽  
K. Hasegawa
Keyword(s):  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Recurrent Tumor

scholarly journals Prognostic Factors for Overall Survival in Advanced Intrahepatic Cholangiocarcinoma Treated with Yttrium-90 Radioembolization

2019 ◽  
Vol 9 (1) ◽  
pp. 56 ◽  
Author(s):  
Michael Köhler ◽  
Fabian Harders ◽  
Fabian Lohöfer ◽  
Philipp M. Paprottka ◽  
Benedikt M. Schaarschmidt ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factors ◽  
Liver Disease ◽  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Tumor Volume ◽  
Cox Regression ◽  
Tertiary Care ◽  
Liver Volume ◽  
Total Liver Volume

Purpose: To evaluate factors associated with survival following transarterial 90Y (yttrium) radioembolization (TARE) in patients with advanced intrahepatic cholangiocarcinoma (ICC). Methods: This retrospective multicenter study analyzed the outcome of three tertiary care cancer centers in patients with advanced ICC following resin microsphere TARE. Patients were included either after failed previous anticancer therapy, including relapse after surgical resection, or for having a minimum of 25% of total liver volume affected by ICC. Patients were stratified and response was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) criteria at 3 months. Kaplan–Meier analysis was performed to analyze survival followed by cox regression to determine independent prognostic factors for survival. Results: 46 patients were included (19 male, 27 female), median age 62.5 years (range 29–88 years). A total of 65% of patients had undergone previous therapy, while 63% had a tumor volume > 25% of the entire liver volume. Median survival was 9.5 months (95% CI: 6.1–12.9 months). Due to loss in follow-up, n = 37 patients were included in the survival analysis. Cox regression revealed the extent of liver disease to one or both liver lobes being associated with survival, irrespective of tumor volume (p = 0.041). Patients with previous surgical resection of ICC had significantly decreased survival (3.9 vs. 12.8 months, p = 0.002). No case of radiation-induced liver disease was observed. Discussion: Survival after 90Y TARE in patients with advanced ICC primarily depends on disease extent. Only limited prognostic factors are associated with a general poor overall survival.

scholarly journals Management and Outcomes of Patients with Recurrent Intrahepatic Cholangiocarcinoma Following Previous Curative-Intent Surgical Resection

2015 ◽  
Vol 23 (1) ◽  
pp. 235-243 ◽  
Author(s):  
Gaya Spolverato ◽  
Yuhree Kim ◽  
Sorin Alexandrescu ◽  
Hugo P. Marques ◽  
Jorge Lamelas ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Curative Intent

Factors Predicting Surgical Resection in Patients with Intrahepatic Cholangiocarcinoma and Cirrhosis

2014 ◽  
Vol 27 (4) ◽  
pp. 219-225 ◽  
Author(s):  
Hao Li ◽  
Jin-shu. Wu ◽  
Xin-tian. Wang ◽  
Pin Lv ◽  
Lian-sheng Gong ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection

2009 ◽  
Vol 33 (6) ◽  
pp. 1247-1254 ◽  
Author(s):  
Alfredo Guglielmi ◽  
Andrea Ruzzenente ◽  
Tommaso Campagnaro ◽  
Silvia Pachera ◽  
Alessandro Valdegamberi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma

scholarly journals An Externally Validated Risk Score for Intrahepatic Cholangiocarcinoma following Surgical Resection: A SEER Database Analysis

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S575-S576
Author(s):  
S. Kathir Kamarajah ◽  
R. Bhogal ◽  
C. Coldham ◽  
J. Hodson ◽  
C. Weston ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Risk Score ◽  
Intrahepatic Cholangiocarcinoma ◽  
Seer Database ◽  
Database Analysis

scholarly journals Postoperative CA19-9 Change Is a Useful Predictor of Intrahepatic Cholangiocarcinoma Survival following Liver Resection

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Tae Yoo ◽  
Sang-Jae Park ◽  
Sung-Sik Han ◽  
Seong Hoon Kim ◽  
Seung Duk Lee ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Perineural Invasion ◽  
Resection Margin ◽  
Survival Outcomes ◽  
Preoperative Level ◽  
Clinical Marker ◽  
Node Metastasis ◽  
Independent Risk Factors ◽  
Risk Factors For Survival

Background. To investigate the clinical significance of the perioperative CA19-9 change for predicting survival in intrahepatic cholangiocarcinoma (ICC) patients treated with surgical resection.Methods. We retrospectively reviewed the data from 74 ICC patients treated with surgical resection between April 2001 and July 2010. Perioperative CA19-9 (preoperative level, postoperative lowest level, and level at recurrence) levels were analyzed for patient distribution and survival.Results. Before surgery, there were 45 patients who had high preoperative CA19-9 levels (>37 U/mL) and 29 who had normal levels (≤37 U/mL). Of 45 patients with high CA19-9 levels, 34 had normalized CA19-9 levels after resection and 11 had persistently high levels. Of 34 patients with normalized CA19-9 levels, 18 showed recurrence. Of 29 patients with normal preoperative levels, 15 showed recurrence. Multivariate analysis presented that old age (hazard ratio [HR] = 3.881,p<0.01), persistently high postoperative CA19-9 level (HR = 4.41,p<0.001), perineural invasion (HR = 3.073,p=0.01), narrow resection margin (HR = 3.152,p=0.05), and lymph node metastasis (HR = 3.427,p=0.02) were significant independent risk factors for survival.Conclusions. Patients who have normalized CA19-9 levels postoperatively have longer survival outcomes. Therefore, normalized postoperative CA19-9 may be a useful clinical marker for ICC survival.

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