Immunohistochemical profiling of cytokeratin expression by endometrial stroma sarcoma

2008 ◽  
Vol 39 (10) ◽  
pp. 1459-1464 ◽  
Author(s):  
Patrick A. Adegboyega ◽  
Suimin Qiu
Keyword(s):  
Endometrial Stroma ◽  
Cytokeratin Expression ◽  
Endometrial Stroma Sarcoma

scholarly journals Long‐term impact of lymphadenectomies in patients with low‐grade, early‐stage uterine endometrial stroma sarcoma

2020 ◽  
Vol 46 (4) ◽  
pp. 654-662
Author(s):  
Yuanyuan Zhang ◽  
Ning Li ◽  
Wenpeng Wang ◽  
Hongwen Yao ◽  
Jusheng An ◽  
...  
Keyword(s):  
Early Stage ◽  
Low Grade ◽  
Endometrial Stroma ◽  
Long Term Impact ◽  
Endometrial Stroma Sarcoma

Endometrial stroma sarcoma

1981 ◽  
Vol 60 (4) ◽  
pp. 385-388 ◽  
Author(s):  
Helen Marie Henriksen ◽  
Per Hornbøll
Keyword(s):  
Endometrial Stroma ◽  
Endometrial Stroma Sarcoma

ÜBER DIE BILDUNG VON ENDOMETRIALEN KÖRNCHENZELLEN BEI KASTRATINNEN UNTER HORMONEINFLUSS

1960 ◽  
Vol XXXIII (II) ◽  
pp. 261-276 ◽  
Author(s):  
G. Hellweg ◽  
J. Ferin ◽  
K. G. Ober
Keyword(s):  
Hormone Therapy ◽  
Stromal Cells ◽  
Sex Hormone ◽  
Substitution Therapy ◽  
Secretory Phase ◽  
Hormone Substitution ◽  
Endometrial Stromal Cells ◽  
Endometrial Stroma ◽  
K Cells

ABSTRACT 65 endometrial biopsies from castrated women who had received either natural or artificial sex hormone therapy were studied microscopically. Attention was paid to various histologic criteria, especially to the number of endometrial granulocytes (»K« cells, KZ). The following was obtained: The »K« cells are completely absent when no hormone substitution therapy is given. They were also lacking when the castrated patients were treated only with oestrogens, even if the dose given was ten-times that found in women during the reproductive ages. In contrast, the »K« cells developed from the endometrial stromal cells only under influence of progesterone, usually appearing first 8–10 days after the administration of the gestagen. The »K« cells were demonstrable in the number corresponding to a normal secretory phase only then, when the oestrogen-progesterone dosage ratio had induced a fully-developed secretory change, as measured by the usual histologic criteria. With an overdosage of oestrogen the »K« cells were either absent or were very sparse. Contrarily, an overdosage of progesterone had no influence on their number. The development of endometrial glands does not always entirely parallel that of the stroma in castrated patients following hormone therapy. A more exact indicator for the proper dose for the production of a secretory phase by hormone therapy seems to be the number of »K« cells in the endometrial stroma.

scholarly journals COUP-TFII Regulates Human Endometrial Stromal Genes Involved in Inflammation

2013 ◽  
Vol 27 (12) ◽  
pp. 2041-2054 ◽  
Author(s):  
Xilong Li ◽  
Michael J. Large ◽  
Chad J. Creighton ◽  
Rainer B. Lanz ◽  
Jae-Wook Jeong ◽  
...  
Keyword(s):  
Cell Fate ◽  
Cell Biology ◽  
Embryo Implantation ◽  
Orphan Nuclear Receptor ◽  
Loss Of Function ◽  
Mouse Uterus ◽  
Endometrial Stromal Cells ◽  
Endometrial Stroma ◽  
Stroma Cell

Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; NR2F2) is an orphan nuclear receptor involved in cell-fate specification, organogenesis, angiogenesis, and metabolism. Ablation of COUP-TFII in the mouse uterus causes infertility due to defects in embryo attachment and impaired uterine stromal cell decidualization. Although the function of COUP-TFII in uterine decidualization has been described in mice, its role in the human uterus remains unknown. We observed that, as in mice, COUP-TFII is robustly expressed in the endometrial stroma of healthy women, and its expression is reduced in the ectopic lesions of women with endometriosis. To interrogate the role of COUP-TFII in human endometrial function, we used a small interfering RNA-mediated loss of function approach in primary human endometrial stromal cells. Attenuation of COUP-TFII expression did not completely block decidualization; rather it had a selective effect on gene expression. To better elucidate the role of COUP-TFII in endometrial stroma cell biology, the COUP-TFII transcriptome was defined by pairing microarray comparison with chromatin immunoprecipitation followed by deep sequencing. Gene ontology analysis demonstrates that COUP-TFII regulates a subset of genes in endometrial stroma cell decidualization such as those involved in cell adhesion, angiogenesis, and inflammation. Importantly this analysis shows that COUP-TFII plays a role in controlling the expression of inflammatory cytokines. The determination that COUP-TFII plays a role in inflammation may add insight into the role of COUP-TFII in embryo implantation and in endometrial diseases such as endometriosis.

Simple epithelial cytokeratin-expression in seborrheic keratosis

1992 ◽  
Vol 19 (5) ◽  
pp. 415-422 ◽  
Author(s):  
M. Nindl ◽  
H. Nakagawa ◽  
M. Furue ◽  
Y. Ishibashi
Keyword(s):  
Seborrheic Keratosis ◽  
Cytokeratin Expression

Bladder cancer discovered by ovarian metastasis: Cytokeratin expression is useful when making differential diagnosis

2005 ◽  
Vol 12 (1) ◽  
pp. 104-107 ◽  
Author(s):  
YASUHIKO ISHII ◽  
NAOKI ITOH ◽  
ATSUSHI TAKAHASHI ◽  
NAOYA MASUMORI ◽  
TATSURU IKEDA ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Differential Diagnosis ◽  
Ovarian Metastasis ◽  
Cytokeratin Expression

Differential Expression of Cytokeratins 8 and 20 Distinguishes Craniopharyngioma From Rathke Cleft Cyst

2002 ◽  
Vol 126 (10) ◽  
pp. 1174-1178 ◽  
Author(s):  
Wei Xin ◽  
Mark A. Rubin ◽  
Paul E. McKeever
Keyword(s):  
Molecular Weight ◽  
Differential Expression ◽  
Expression Patterns ◽  
Primary Diagnosis ◽  
Pars Intermedia ◽  
Rathke Cleft Cyst ◽  
Cytokeratin Expression ◽  
Pituitary Glands ◽  
Clinically Significant ◽  
Difficult Cases

Abstract Background.—Craniopharyngiomas are epithelial neoplasms usually located in the sellar and suprasellar regions. Distinguishing craniopharyngioma from Rathke cleft cyst is sometimes difficult, and the distinction is clinically significant because Rathke cleft cysts have a better prognosis than craniopharyngiomas. Design.—We retrieved 10 cases with a primary diagnosis of craniopharyngioma and 5 cases with a diagnosis of Rathke cleft cyst for analysis. Five cases of normal pars intermedia of pituitary glands from autopsy served as controls. We evaluated the expression patterns of a broad range of low– to intermediate–molecular weight cytokeratins (CK7, CK8, CK10, CK17, CK18, CK19, and CK20) and high–molecular weight cytokeratins (K903: a combination of CK1, CK5, CK10, and CK14; and CK5/6) in these cases. Results.—Craniopharyngiomas had a cytokeratin expression pattern distinct from that of Rathke cleft cysts and pituitary gland pars intermedia: craniopharyngiomas did not express cytokeratins 8 and 20, whereas Rathke cleft cysts and pars intermedia of pituitary glands both expressed cytokeratins 8 and 20. Conclusion.—The differential expression of cytokeratins distinguishes between craniopharyngioma and Rathke cleft cyst, and this difference could be useful for identifying craniopharyngioma in difficult cases in which only a small biopsy is available. The different cytokeratin profiles of craniopharyngioma and Rathke cleft cyst suggest that these lesions do not come from the same origin, or that they come from a different developmental stage of the pouch epithelium.

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