Evaluation of the effects of probiotic yoghurt on inflammation and cardiometabolic risk factors in subjects with metabolic syndrome: A randomised controlled trial

IntroductionCardiovascular and metabolic diseases are a growing concern for individuals with spinal cord injury (SCI). Physical inactivity contributes to cardiometabolic morbidity and mortality in the SCI population. However, previous studies have shown mixed results regarding the effects of exercise on cardiometabolic risk factors in individuals with SCI. This discrepancy could be influenced by insufficient exercise stimuli. Recent guidelines recommend 30 min of moderate-to-vigorous intensity aerobic exercise, three times per week, for improvement in cardiometabolic health in individuals with SCI. However, to date, no studies have implemented an exercise intervention matching the new recommendations to examine the effects on cardiometabolic risk factors. Therefore, the primary objective of this study is to determine the effects of 12 weeks of wheelchair user-modified upper-body rowing exercise on both traditional (constituents of the metabolic syndrome) and novel (eg, vascular structure and function) cardiometabolic risk factors in manual wheelchair users with SCI.Methods and analysisA randomised controlled trial will compare 12 weeks of upper-body rowing exercise, 30 min three times per week, with a control group continuing their normal lifestyle. Outcome measurements will be performed immediately before (baseline), after 6 weeks (halfway), 12 weeks of training (post) and 6 months after the termination of the intervention period (follow-up). Outcomes will include inflammatory (eg, C reactive protein) and metabolic biomarkers determined from venous blood (with serum fasting insulin as primary outcome), body composition, arterial blood pressure, cardiorespiratory fitness level, brachial artery vascular structure and function and autonomic nervous system function.Ethics and disseminationThis trial is reported to the Danish Data Protection Agency (J.nr. 2019-899/10-0406) and approved by the Committees on Health Research Ethics in The North Denmark Region on 12 December 2019 (J.nr. N-20190053). The principal investigator will collect written informed consent from all participants prior to inclusion. Irrespective of study outcomes, the results will be submitted to peer-reviewed scientific journals for publication.Trial registration numberNCT04390087.

Download Full-text

Home-based lifestyle intervention for rural adults improves metabolic syndrome parameters and cardiovascular risk factors: A randomised controlled trial

Preventive Medicine ◽

10.1016/j.ypmed.2016.05.012 ◽

2016 ◽

Vol 89 ◽

pp. 15-22 ◽

Cited By ~ 20

Author(s):

Krysten Blackford ◽

Jonine Jancey ◽

Andy H. Lee ◽

Anthony P. James ◽

Tracy Waddell ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Randomised Controlled Trial ◽

Cardiovascular Risk Factors ◽

Lifestyle Intervention ◽

Controlled Trial ◽

Home Based ◽

Randomised Controlled ◽

Rural Adults

Download Full-text

Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses: baseline data from the IMPaCT randomized controlled trial

Psychological Medicine ◽

10.1017/s0033291715000562 ◽

2015 ◽

Vol 45 (12) ◽

pp. 2619-2629 ◽

Cited By ~ 63

Author(s):

P. Gardner-Sood ◽

J. Lally ◽

S. Smith ◽

Z. Atakan ◽

K. Ismail ◽

...

Keyword(s):

Mental Health ◽

Risk Factors ◽

Metabolic Syndrome ◽

Randomized Controlled Trial ◽

Functional Impairment ◽

Cardiometabolic Risk ◽

Controlled Trial ◽

Baseline Data ◽

Cardiometabolic Risk Factors ◽

Randomized Controlled

BackgroundThe aims of the study were to determine the prevalence of cardiometabolic risk factors and establish the proportion of people with psychosis meeting criteria for the metabolic syndrome (MetS). The study also aimed to identify the key lifestyle behaviours associated with increased risk of the MetS and to investigate whether the MetS is associated with illness severity and degree of functional impairment.MethodBaseline data were collected as part of a large randomized controlled trial (IMPaCT RCT). The study took place within community mental health teams in five Mental Health NHS Trusts in urban and rural locations across England. A total of 450 randomly selected out-patients, aged 18–65 years, with an established psychotic illness were recruited. We ascertained the prevalence rates of cardiometabolic risk factors, illness severity and functional impairment and calculated rates of the MetS, using International Diabetes Federation (IDF) and National Cholesterol Education Program Third Adult Treatment Panel criteria.ResultsHigh rates of cardiometabolic risk factors were found. Nearly all women and most men had waist circumference exceeding the IDF threshold for central obesity. Half the sample was obese (body mass index ≥ 30 kg/m2) and a fifth met the criteria for type 2 diabetes mellitus. Females were more likely to be obese than males (61% v. 42%, p < 0.001). Of the 308 patients with complete laboratory measures, 57% (n = 175) met the IDF criteria for the MetS.ConclusionsIn the UK, the prevalence of cardiometabolic risk factors in individuals with psychotic illnesses is much higher than that observed in national general population studies as well as in most international studies of patients with psychosis.

Download Full-text

Effects of a lifestyle modification programme to reduce the number of risk factors for metabolic syndrome: a randomised controlled trial

Public Health Nutrition ◽

10.1017/s1368980016001920 ◽

2016 ◽

Vol 20 (1) ◽

pp. 142-153 ◽

Cited By ~ 9

Author(s):

Mariko Watanabe ◽

Masako Yokotsuka ◽

Kazue Yamaoka ◽

Misa Adachi ◽

Asuka Nemoto ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

High Risk ◽

Randomised Controlled Trial ◽

Lifestyle Modification ◽

Controlled Trial ◽

Care Group ◽

Personal Support ◽

Randomised Controlled ◽

Male Workers

AbstractObjectiveTo determine the effectiveness of a personal support lifestyle education programme (PSMetS) for reducing risk factors in individuals with metabolic syndrome (MetS).DesignA two-arm randomised controlled trial.SettingCompanies in metropolitan Tokyo, Japan.SubjectsMale workers with diagnosed MetS or a high risk for MetS according to the Counselling Guidance Program, Japan (n 193).ResultsThe reduction in the number of risk factors for MetS (as defined according to the criteria published by the Japanese Ministry of Health, Labor and Welfare in April 2007 (MHLW-MetS)) in the PSMetS group was not significantly different from that in the usual care group by van Elteren’s test (baseline-adjusted P=0·075) for intention-to-treat (ITT), while it was significant (baseline-adjusted P=0·038) for per-protocol set (PPS). The proportion of MHLW-MetS was significantly different between groups by van Elteren’s test (baseline-adjusted P=0·031). Two components of MHLW-MetS showed significant reductions in the PSMetS group: waist circumference (baseline-adjusted P=0·001) and BMI (baseline-adjusted P=0·002). PPS and ITT analyses showed similar results.ConclusionsFor male workers with MHLW-MetS or a high risk of MHLW-MetS, PSMetS reduced the number of risk factors for MHLW-MetS.

Download Full-text