Influence of natural and synthetic metalloproteinase inhibitors on bonding durability of an etch-and-rinse adhesive to dentin

2013 ◽  
Vol 47 ◽  
pp. 83-88 ◽  
Author(s):  
T.M.A. Monteiro ◽  
R.T. Basting ◽  
C.P. Turssi ◽  
F.M.G. França ◽  
F.L.B. Amaral
Keyword(s):  
Etch And Rinse ◽  
Metalloproteinase Inhibitors ◽  
Bonding Durability ◽  
Natural And Synthetic

Effect of Carbodiimide on Bonding Durability of Adhesive-cemented Fiber Posts in Root Canals

2016 ◽  
Vol 41 (4) ◽  
pp. 432-440 ◽  
Author(s):  
F Shafiei ◽  
B Yousefipour ◽  
M Mohammadi-Bassir
Keyword(s):  
Resin Cements ◽  
Maxillary Central Incisor ◽  
Root Canals ◽  
Fiber Posts ◽  
Group Data ◽  
Etch And Rinse ◽  
Bonding Durability ◽  
Root Dentin ◽  
One Year ◽  
Self Etch

SUMMARY This study was undertaken to investigate whether using a protein cross-linker, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), improves bonding stability of fiber posts to root dentin using three resin cements. Sixty human maxillary central incisor roots were randomly divided into six groups after endodontic treatment, according to the cements used with and without EDC pretreatment. In the etch-and-rinse group, 0.3 M EDC aqueous solution was applied on acid-etched root dentin prior to Excite DSC/Variolink II for post cementation. In the self-etch and self-adhesive groups, EDC was used on EDTA-conditioned root space prior to application of ED Primer II/Panavia F2.0 and Clearfil SA, respectively. After microslicing the root dentin, a push-out bond strength (BS) test was performed immediately or after one-year of water storage for each group. Data were analyzed using three-way analysis of variance and Tukey tests (α=0.05). A significant effect of cement type, time, EDC, and Time × Cement and Time × EDC interactions were observed (p≤0.001). EDC pretreatment did not affect immediate bonding of the three cements (p>0.05). Aging significantly reduced the BS in all the groups (p≤0.001), but EDC groups exhibited a higher BS compared with the respective control groups (p<0.001). Despite the significant effect of aging on decreasing the BS of fiber post to radicular dentin, EDC could diminish this effect for the three tested cements.

scholarly journals Effect of green tea extract on bonding durability of an etch-and-rinse adhesive system to caries-affected dentin

2016 ◽  
Vol 24 (3) ◽  
pp. 211-217 ◽  
Author(s):  
Carolina CARVALHO ◽  
Fernando Pelegrim FERNANDES ◽  
Valeria da Penha FREITAS ◽  
Fabiana Mantovani Gomes FRANÇA ◽  
Roberta Tarkany BASTING ◽  
...  
Keyword(s):  
Green Tea ◽  
Adhesive System ◽  
Green Tea Extract ◽  
Etch And Rinse ◽  
Bonding Durability ◽  
Tea Extract

scholarly journals Effect of different concentrations of green tea extract solutions on bonding durability of etch-and-rinse adhesive system to caries affected dentin

2021 ◽  
Vol 20 ◽  
pp. e210328
Author(s):  
Ricky Rolim de Moura ◽  
Fabiana Mantovani Gomes França ◽  
Cecilia Pedroso Turssi ◽  
Roberta Tarkany Basting ◽  
Flavia Lucisano Botelho do Amaral
Keyword(s):  
Bond Strength ◽  
Green Tea ◽  
In Vitro Study ◽  
Adhesive System ◽  
Green Tea Extract ◽  
Etch And Rinse ◽  
Bonding Durability ◽  
Composite Resin Restorations ◽  
Tea Extract

Aim: The in vitro study evaluated the effect of different concentrations of green tea extract solution (GT) on the bonding durability of etch-and-rinse adhesive system to caries dentin affected (CAD). Methods: Dentinal surfaces of human third molars were polished and submitted to a microbiological caries induction protocol for 14 days. After removal of the infected dentin layer, the samples were randomly divided into 4 groups (n= 10), according to the concentration of GT solution applied in CAD, after acid etching: 0.05%; 0.2%; 2% and NT (no treatment – control). After application of a etch-and-rinse adhesive system (Adper Single Bond 2, 3M ESPE), composite resin restorations were performed on the dentin. After 24 hours, the resin-dentin blocks were sectioned 1mm2 specimens, which were subjected to the microtensile test immediately or after 6 months of storage in water. Data were submitted to two-way ANOVA for randomized blocks and Tukey test (α= 5%). Results: There was no effect of double interaction (p= 0.934). The application of 0.2% GT promoted a statistically significant increase in dentin bond strength values in comparison to the condition where GT was not used (p=0.012). There was a significant decrease of bond strength after 6 months of storage, regardless of dentin pretreatment (p = 0.007). The G test identified that there was no statistical difference regarding failure mode (p= 0.326). Conclusion: The concentration of 0.2% improved the bond strength of an etch-and-rinse adhesive system to caries affected dentin, however, none of dentin pretreatments could prevent the decrease in bond strength over time.

Semi-synthesis as a tool for broadening the health applications of bioactive olive secoiridoids: a critical review

2021 ◽  
Author(s):  
Manuela Oliverio ◽  
Monica Nardi ◽  
Maria Luisa Di Gioia ◽  
Paola Costanzo ◽  
Sonia Bonacci ◽  
...  
Keyword(s):  
Critical Review ◽  
Natural Compounds ◽  
Effective Strategy ◽  
Synthetic Analogues ◽  
Health Applications ◽  
Natural And Synthetic

Semi-synthesis is an effective strategy to obtain both natural and synthetic analogues of the olive secoiridoids, starting from easy accessible natural compounds.

Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors

2003 ◽  
Vol 70 ◽  
pp. 201-212 ◽  
Author(s):  
Hideaki Nagase ◽  
Keith Brew
Keyword(s):  
Three Dimensional ◽  
Therapeutic Interventions ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Structural Basis ◽  
Structural Elements ◽  
Ridge Structure ◽  
Extracellular Matrix Components ◽  
Metalloproteinase Inhibitors ◽  
The Matrix ◽  
A Disintegrin And Metalloproteinase

The tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of the matrix metalloproteinases (MMPs), enzymes that play central roles in the degradation of extracellular matrix components. The balance between MMPs and TIMPs is important in the maintenance of tissues, and its disruption affects tissue homoeostasis. Four related TIMPs (TIMP-1 to TIMP-4) can each form a complex with MMPs in a 1:1 stoichiometry with high affinity, but their inhibitory activities towards different MMPs are not particularly selective. The three-dimensional structures of TIMP-MMP complexes reveal that TIMPs have an extended ridge structure that slots into the active site of MMPs. Mutation of three separate residues in the ridge, at positions 2, 4 and 68 in the amino acid sequence of the N-terminal inhibitory domain of TIMP-1 (N-TIMP-1), separately and in combination has produced N-TIMP-1 variants with higher binding affinity and specificity for individual MMPs. TIMP-3 is unique in that it inhibits not only MMPs, but also several ADAM (a disintegrin and metalloproteinase) and ADAMTS (ADAM with thrombospondin motifs) metalloproteinases. Inhibition of the latter groups of metalloproteinases, as exemplified with ADAMTS-4 (aggrecanase 1), requires additional structural elements in TIMP-3 that have not yet been identified. Knowledge of the structural basis of the inhibitory action of TIMPs will facilitate the design of selective TIMP variants for investigating the biological roles of specific MMPs and for developing therapeutic interventions for MMP-associated diseases.

Review of Natural and synthetic tyrosinase inhibitors

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
F Namjooyan ◽  
H Moosavi ◽  
A Taherian
Keyword(s):  
Tyrosinase Inhibitors ◽  
Natural And Synthetic

Natural and synthetic indirubins as potent and selective inhibitors of the protozoan parasite Leishmania donovani

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
E Xingi ◽  
D Smirlis ◽  
S Bisti ◽  
V Myrianthopoulos ◽  
P Magiatis ◽  
...  
Keyword(s):  
Leishmania Donovani ◽  
Protozoan Parasite ◽  
Selective Inhibitors ◽  
Parasite Leishmania ◽  
Natural And Synthetic

THE AUTORADIOGRAPHIC DISTRIBUTION PATTERN AFTER ADMINISTRATION OF DIETHYLSTILBOESTROL COMPARED WITH THAT OF NATURAL OESTROGENS

1963 ◽  
Vol 43 (4) ◽  
pp. 561-570 ◽  
Author(s):  
Gösta Bengtsson ◽  
Sven Ullberg
Keyword(s):  
Distribution Pattern ◽  
Adrenal Cortex ◽  
Natural Compounds ◽  
Ovarian Follicles ◽  
Interstitial Tissue ◽  
Specific Accumulation ◽  
Natural And Synthetic

ABSTRACT The distribution in mice of 14C- and 3H-diethylstilboestrol has been investigated autoradiographically. The results have been compared with those which have been previously reported for natural oestrogens. Many similarities have been demonstrated between the synthetic and natural compounds. Thus a specific accumulation has been observed in the endometrium, the granulosa layer of large ovarian follicles, the adrenal cortex. the interstitial tissue of the testes, and the hypophysis. Natural and synthetic oestrogens differ widely concerning the penetration into and the distribution within the foetus.

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