Antibacterial immunomodulatory and antibiofilm triple effect of Salivaricin LHM against Pseudomonas aeruginosa urinary tract infection model

Current study obtained (75) isolate of Pseudomonas aeruginosa collected from different cases included : 28 isolates from otitis media, 23 isolates from burn infections, 10 isolates from wound infections, 8 isolates from urinary tract infections and 6 isolates from blood, during the period between 1/9/2014 to 1/11/2014 The result revealed that the tox A gene was present in 54 isolates (72%) of Pseudomonas aeruginosa. The gel electrophoresis showed that the molecular weight of tox A gene was 352 bp. The result shows 17 isolates (60.71%) from otitis media has tox A gene, 18 isolates (78.26%) from burn followed by 8 isolate (80%) from wound infection and 5 isolates (62.5%) from urinary tract infection , finally 6 isolates (100%) from blood have this gene.

Download Full-text

Bacteriophage therapy for refractory Pseudomonas aeruginosa urinary tract infection

Journal of Medical Microbiology ◽

10.1099/jmm.0.029744-0 ◽

2011 ◽

Vol 60 (11) ◽

pp. 1697-1700 ◽

Cited By ~ 57

Author(s):

A. Khawaldeh ◽

S. Morales ◽

B. Dillon ◽

Z. Alavidze ◽

A. N. Ginn ◽

...

Keyword(s):

Pseudomonas Aeruginosa ◽

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Bacteriophage Therapy

Download Full-text

Molecular detection of six virulence genes in Pseudomonas aeruginosa isolates detected in children with urinary tract infection

Microbial Pathogenesis ◽

10.1016/j.micpath.2017.03.009 ◽

2017 ◽

Vol 107 ◽

pp. 44-47 ◽

Cited By ~ 10

Author(s):

Ali Badamchi ◽

Hossein Masoumi ◽

Shima Javadinia ◽

Ramin Asgarian ◽

Azardokht Tabatabaee

Keyword(s):

Pseudomonas Aeruginosa ◽

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Virulence Genes ◽

Molecular Detection

Download Full-text

Therapeutic Efficacy of Sitafloxacin Against Pseudomonas aeruginosa in a Rat Model of Urinary Tract Infection

Drugs ◽

10.2165/00003495-199958002-00145 ◽

1999 ◽

Vol 58 (Supplement 2) ◽

pp. 412-414 ◽

Cited By ~ 1

Author(s):

Yuichi Kurosaka ◽

Yoshihisa Ishida ◽

Eiko Yamamura ◽

Tsuyoshi Otani ◽

Hiromi Kumon

Keyword(s):

Pseudomonas Aeruginosa ◽

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Rat Model ◽

Therapeutic Efficacy

Download Full-text

Use of Continuous-Infusion Ceftolozane/Tazobactam in a Multidrug-Resistant Pseudomonas aeruginosa Urinary Tract Infection in the Outpatient Setting

Annals of Pharmacotherapy ◽

10.1177/1060028017701938 ◽

2017 ◽

Vol 51 (8) ◽

pp. 715-716 ◽

Cited By ~ 8

Author(s):

Bruce M. Jones ◽

Bradley Smith ◽

Christopher M. Bland

Keyword(s):

Pseudomonas Aeruginosa ◽

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Continuous Infusion ◽

Multidrug Resistant ◽

Outpatient Setting

Download Full-text

Evaluation of Antibacterial Potential of Ethanol Fruit Peel Extract of Mangifera indica against Isolated UTI Pathogens

Nigerian Journal of Pure and Applied Sciences ◽

10.48198/njpas/21.a14 ◽

2021 ◽

pp. 3998-4005

Author(s):

Adeyinka A. Aderinola ◽

Jane Ejiofor ◽

Lukmon Ogunjimi ◽

Akanji A. Murtala ◽

Oladapo E. Oyinloye

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Mangifera Indica ◽

Inhibition Zone ◽

Fruit Peel ◽

Gram Negative ◽

Peel Extract

Effective use of antimicrobial agents for treatment/management of infectious diseases is decreasing due to emergency of multi-drug and cross resistant strains of pathogenic microbes. Medicinal plants are now increasingly used alone or as an adjunct in the management of infectious diseases as a result of their claimed efficacy and safety. This research focused on evaluating the antimicrobial potential of ethanol fruit peel extract of Mangifera indica against isolated Urinary tract infection (UTI) pathogens. Urinary tract infection (UTI) bacterial strains (staphylococcus aureus, escherichia coli and pseudomonas aeruginosa) were isolated from midstream urine of infected students using standard procedures after which the isolated Urinary tract infection pathogens were subjected to antimicrobial susceptibility test by agar-well diffusion method (Cup plate method) and the mean diameter of growth inhibition zones (n=3) of the extract at different concentrations were compared against the controls (sterile water and ciprofloxacin). Ethanol fruit peel extract of Mangifera indica significantly and dose dependently inhibit the growth of all the isolated Urinary tract infection pathogens with E.coli exhibiting the highest inhibition zone ranging from 16.83 to 28.23 mm, this was followed by pseudomonas aeruginosa with inhibition zone of 24.33 mm and staphylococcus aureus least susceptible with 22.63 diameter of zone inhibition. Ethanol fruit peel extract of Mangifera indica demonstrated a dose dependent antimicrobial activity with more pronounced effect exhibited by E. coli suggesting that the extract is more effective against gram negative bacteria despite their permeability barrier, thus suggesting Mangifera indica fruit peel as a potential candidate for the management of bacterial infections especially those caused by gram negative organisms.

Download Full-text