The mineralization process of insoluble elastin fibrillar structures: Ionic environment vs degradation

2020 ◽  
Vol 149 ◽  
pp. 693-706 ◽  
Author(s):  
Federica Boraldi ◽  
Pasquale Moscarelli ◽  
Francesco Demetrio Lofaro ◽  
Carla Sabia ◽  
Daniela Quaglino
Author(s):  
Gregory J. Czarnota

Chromatin structure at the fundamental level of the nucleosome is important in vital cellular processes. Recent biochemical and genetic analyses show that nucleosome structure and structural changes are very active participants in gene expression, facilitating or inhibiting transcription and reflecting the physiological state of the cell. Structural states and transitions for this macromolecular complex, composed of DNA wound about a heterotypic octamer of variously modified histone proteins, have been measured by physico-chemical techniques and by enzyme-accessibility and are recognized to occur with various post-translational modifications, gene activation, transformation and with ionic-environment. In spite of studies which indicate various forms of nucleosome structure, all current x-ray and neutron diffraction studies have consistently resulted in only one structure, suggestive of a static conformation. In contrast, two-dimensional electron microscopy studies and three-dimensional reconstruction techniques have yielded different structures. These fundamental differences between EM and other ultrastructural studies have created a long standing quandary, which I have addressed and resolved using spectroscopic electron microscopy and statistical analyses of nucleosome images in a study of nucleosome structure with ionic environment.


2018 ◽  
Vol 69 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Monica Ihos ◽  
Corneliu Bogatu ◽  
Carmen Lazau ◽  
Florica Manea ◽  
Rodica Pode

The aim of this study was the investigation of photocatalytic degradation of pharmaceutically active compounds using doped TiO2 functionalized zeolite photocatalyst. Diclofenac (DCF), a non-steroidal anti-inflammatory drug, that represents a biorefractory micropollutant, was chosen as model of pharmaceutically active compound. The photocatalyst was Z-TiO2-Ag. The concentration of DCF in the working solutions was 10 mg/L,50 mg/L,100 mg/L and 200 mg/L and of photocatalyst 1 g/L in any experiments. The process was monitored by recording the UV spectra of the treated solutions and total organic carbon (TOC) determination. The UV spectra analysis and TOC removal proved that along the advanced degradation of DCF also a mineralization process occurred. The carried out research provided useful information envisaging the treatment of pharmaceutical effluents by photocatalysis.


1963 ◽  
Vol 26 (6) ◽  
pp. 948-957 ◽  
Author(s):  
Charles Edwards ◽  
Carlo A. Terzuolo ◽  
Yoshiaki Washizu

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eri Nakamura ◽  
Noriaki Ozaki ◽  
Yuya Oaki ◽  
Hiroaki Imai

AbstractThe essence of morphological design has been a fascinating scientific problem with regard to understanding biological mineralization. Particularly shaped amorphous silicas (plant opals) play an important role in the vital activity in rice plants. Although various organic matters are associated with silica accumulation, their detailed functions in the shape-controlled mineralization process have not been sufficiently clarified. In the present study, cellulose nanofibers (CNFs) were found to be essential as a scaffold for silica accumulation in rice husks and leaf blades. Prior to silicification, CNFs ~ 10 nm wide are sparsely stacked in a space between the epidermal cell wall and the cuticle layer. Silica nanoparticles 20–50 nm in diameter are then deposited in the framework of the CNFs. The shape-controlled plant opals are formed through the intrafibrillar mineralization of silica nanoparticles on the CNF scaffold.


2008 ◽  
Vol 308 (1-2) ◽  
pp. 218-229 ◽  
Author(s):  
W.J.C. van de Ven ◽  
K. van’t Sant ◽  
I.G.M. Pünt ◽  
A. Zwijnenburg ◽  
A.J.B. Kemperman ◽  
...  

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 131
Author(s):  
Federica Boraldi ◽  
Francesco Demetrio Lofaro ◽  
Daniela Quaglino

Extraosseous calcification is a pathologic mineralization process occurring in soft connective tissues (e.g., skin, vessels, tendons, and cartilage). It can take place on a genetic basis or as a consequence of acquired chronic diseases. In this last case, the etiology is multifactorial, including both extra- and intracellular mechanisms, such as the formation of membrane vesicles (e.g., matrix vesicles and apoptotic bodies), mitochondrial alterations, and oxidative stress. This review is an overview of extraosseous calcification mechanisms focusing on the relationships between apoptosis and mineralization in cartilage and vascular tissues, as these are the two tissues mostly affected by a number of age-related diseases having a progressively increased impact in Western Countries.


Author(s):  
Shivam Tiwari ◽  
Abhijit Gogoi ◽  
K. Anki Reddy

The effect of the ionic environment on membrane fouling was investigated for polyamide (PA) and graphene oxide (GO) membranes using equilibrium molecular dynamics (MD) simulations.


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