Diagnostic potential and future directions of matrix metalloproteinases as biomarkers in gingival crevicular fluid of oral and systemic diseases

2021 ◽  
Author(s):  
Fan Zhang ◽  
Enyan Liu ◽  
Allan Radaic ◽  
Xiaotong Yu ◽  
Shuting Yang ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Gingival Crevicular Fluid ◽  
Systemic Diseases ◽  
Future Directions ◽  
Diagnostic Potential ◽  
Crevicular Fluid

scholarly journals Possible interaction between visfatin, periodontal infection, and other systemic diseases: A brief review of literature

2017 ◽  
Vol 11 (03) ◽  
pp. 407-410 ◽  
Author(s):  
Mojtaba Bayani ◽  
Mohammad Pourali ◽  
Mohammad Keivan
Keyword(s):  
Periodontal Disease ◽  
Bacterial Infections ◽  
Alveolar Bone ◽  
Gingival Crevicular Fluid ◽  
Systemic Diseases ◽  
Hand Search ◽  
Periodontal Infection ◽  
Etiologic Agents ◽  
Visfatin Level ◽  
Crevicular Fluid

ABSTRACTGingivitis and periodontitis are common bacterial infections caused by a variety of microorganisms. Despite the microorganisms' roles as etiologic agents, inflammation-induced substances also have crucial parts in the loss of connective tissue and the supporting alveolar bone. Visfatin is a pleiotropic mediator, which acts as growth factor, cytokine, and pre-B-cell colony-enhancing factor. A positive correlation was detected between the serum/plasma levels of visfatin and inflammatory disorders such as diabetes mellitus and cardiovascular disease. In addition, the visfatin level was higher in saliva and the gingival crevicular fluid (GCF) of subjects with periodontal disease. This review defined current, predictable patterns of possible interaction of visfatin with periodontal infection and other systemic diseases, using PubMed and Medline databases searching for articles written in English. Peer-reviewed articles were targeted using the following keywords: “visfatin,” “periodontal disease,” “inflammatory mediator,” and “biomarker.” Available full-text articles were read, and related articles were also scrutinized, while a hand search was also performed. Search was confined to human studies, and articles written in English and published between 1985 and 2016 were selected. It was concluded that periodontal infection and other systemic diseases could be related to the levels of visfatin in GCF, saliva, and serum as a biomarker of these diseases.

scholarly journals Matrix metalloproteinases and chemokines in the gingival crevicular fluid during orthodontic tooth movement

2011 ◽  
Vol 33 (6) ◽  
pp. 705-711 ◽  
Author(s):  
J. Capelli Junior ◽  
A. Kantarci ◽  
A. Haffajee ◽  
R. P. Teles ◽  
R. Fidel ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Tooth Movement ◽  
Gingival Crevicular Fluid ◽  
Orthodontic Tooth Movement ◽  
Crevicular Fluid

Analysis of matrix metalloproteinases, especially MMP-8, in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases

2015 ◽  
Vol 70 (1) ◽  
pp. 142-163 ◽  
Author(s):  
Timo Sorsa ◽  
Ulvi K. Gursoy ◽  
Solomon Nwhator ◽  
Marcela Hernandez ◽  
Taina Tervahartiala ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Gingival Crevicular Fluid ◽  
Periodontal Diseases ◽  
Crevicular Fluid

Diagnostic Potential of Host Response Mediators

1993 ◽  
Vol 7 (2) ◽  
pp. 175-181 ◽  
Author(s):  
S. Offenbacher ◽  
J.G. Collins ◽  
P.A. Heasman
Keyword(s):  
Disease Activity ◽  
Host Response ◽  
Gingival Crevicular Fluid ◽  
Diagnostic Tools ◽  
Predictive Values ◽  
Diagnostic Measures ◽  
Diagnostic Potential ◽  
Crevicular Fluid ◽  
Sensitivity Specificity ◽  
Considerable Body

This review summarizes the data which relate the validation and application of host response markers as diagnostic tests forperiodontal diseases. Practical considerations regarding the general application and evaluation of a diagnostic test for periodontal disease are presented. Experiments which have documented the performance of host response markers as diagnostic measures of disease activity in terms of sensitivity, specificity, and predictive values are summarized. Particular emphasis is placed on the diagnostic potential of gingival crevicular fluid (GCF) components. The considerable body of evidence supporting the potential application of GCF-PGE2 levels for predicting episodes of disease progression and reflecting disease activity is summarized and placed into perspective for the development of future diagnostic tools.

scholarly journals Levels of gingival crevicular fluid matrix metalloproteinases in periodontally compromised teeth under orthodontic forces

2015 ◽  
Vol 85 (6) ◽  
pp. 1009-1014 ◽  
Author(s):  
Rhita C. Almeida ◽  
Jonas Capelli ◽  
Ricardo P. Teles
Keyword(s):  
Matrix Metalloproteinases ◽  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Statistical Tests ◽  
Dental Arch ◽  
Orthodontic Movement ◽  
Significant Difference ◽  
Movement Group ◽  
Crevicular Fluid ◽  
Orthodontic Forces

ABSTRACT Objective:  To examine levels of matrix metalloproteinases (MMPs)-1, -2, -3, -7, -8, -12, and -13 in the gingival crevicular fluid (GCF) of periodontally compromised teeth at different time points during orthodontic movement. Materials and Methods:  Ten controlled periodontitis subjects were submitted to orthodontic treatment. One dental arch was subjected to orthodontic movement, and teeth in the opposite arch were used as controls. GCF samples were collected from the lingual sites of two movement and two control incisors 1 week before orthodontic activation (−7 d), immediately after orthodontic activation, and after 1 hour, 24 hours, and 7, 14, and 21 days. Multiplexed bead immunoassay was used to measure MMPs in GCF. Data were analyzed using Friedman and Wilcoxon statistical tests. Results:  The only significant change found over time was in the levels of MMP-1 in the movement group (P < .05). When the two groups were compared after activation, the only statistically significant difference found was in levels of MMP-12 24 hours after activation (P < .05). Conclusions:  Our findings suggested that the orthodontic movement of periodontally compromised teeth without active pockets did not result in significant changes in the GCF levels of MMPs.

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