Serum uric acid is associated with common cardiovascular risk factors in Uygur population

BACKGROUND AND OBJECTIVE: we have examined the concentration of serum uric acid and the serum uric acid/creatinine ratio as well as their correlations with the main determinants of the hemorheological profile in a group of subjects with subclinical carotid atherosclerosis. METHODS: we evaluated the concentration of serum uric acid and the serum uric acid/creatine ratio in 43 men and 57 women [median age 66.00 (25)] with subclinical carotid atherosclerosis, subsequently divided according to the number of traditional cardiovascular risk factors and to the insulin resistance degree. RESULTS: serum uric acid, but not the serum uric acid/creatinine ratio, results strongly influenced by the number of cardiovascular risk factors and by the insulin resistance degree. In the whole group and in the subgroups of subclinical carotid atherosclerosis subjects, serum uric acid and serum uric acid/creatinine ratio show significant correlation, besides with whole blood viscosity, with plasma viscosity and erythrocyte aggregation. The influence of the serum uric acid on the erythrocyte aggregability that is a part of the erythrocyte aggregation is to ascribe to the action carried out by serum uric acid on the erythrocyte zeta potential. CONCLUSIONS: it is reasonable to think that the treatment of the asymptomatic or symptomatic hyperuricemia with the urate-lowering therapy that reduces the serum uric acid concentration may reflect on the hemorheological profile which role on the atherosclerotic cardiovascular disease is well known.

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Association of High Serum Uric Acid and Increased Arterial Stiffness is Dependent on Cardiovascular Risk Factors in Female Population

Hormone and Metabolic Research ◽

10.1055/a-0882-7382 ◽

2019 ◽

Vol 51 (06) ◽

pp. 367-374 ◽

Cited By ~ 3

Author(s):

Yin Yuan ◽

Feng Huang ◽

Fan Lin ◽

Min Lin ◽

Pengli Zhu

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Risk ◽

Arterial Stiffness ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Pulse Wave ◽

Elevated Serum ◽

High Serum ◽

Female Population

AbstractAn elevated serum uric acid (SUA) level is closely associated with increased arterial stiffness. However, whether this association is independent of conventional cardiovascular risk factors is controversial. This study aimed to investigate whether SUA is independently associated with arterial stiffness as assessed by Brachial-ankle pulse wave velocity (baPWV), and to what extent this association is dependent on cardiovascular risk factors. Increased arterial stiffness was defined as baPWV>1 400 cm/s. Cardiovascular risk factors were defined as hypertension, diabetes, dyslipidaemia, and a BMI≥24.0 kg/m2. A total of 3 342 subjects (1 334 men and 2008 women, mean age 53.79±13.18 years) were included. SUA levels exhibited a graded elevation with an increasing number of cardiovascular risk factors. In female subjects with more than two cardiovascular risk factors, compared with the first quartile of SUA, higher SUA quartiles were associated with a higher probability of increased baPWV (OR=1.500, 1.478, 1.774 for SUA Q2–Q4). In further stratified association analysis, compared with Q1, SUA quartiles showed a graded association with increased baPWV in subjects with TC≥5.2 mmol/l (OR=1.758, 1.942, 2.354 for Q2, Q3, and Q4 respectively), LDL-C≥3.3 mmol/l (OR=1.510, 2.255 for Q3 and Q4) and FBG≥7.0 mmol/l (OR=1.516, 1.748 for Q3 and Q4). In the Chinese coastal female population, the association of high SUA and increased arterial stiffness is dependent on the coexistence of at least one cardiovascular risk factor, especially hypercholesterolemia.

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Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country

BMC Public Health ◽

10.1186/1471-2458-4-9 ◽

2004 ◽

Vol 4 (1) ◽

Cited By ~ 152

Author(s):

D Conen ◽

V Wietlisbach ◽

P Bovet ◽

C Shamlaye ◽

W Riesen ◽

...

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Developing Country ◽

Serum Uric Acid

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P6232Exploring the bottom of J-shaped curve association between serum uric acid and cardiovascular risks: description using a large Japanese general population

European Heart Journal ◽

10.1093/eurheartj/ehz746.0834 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

S Kawasoe ◽

T Kubozono ◽

S Ojima ◽

H Miyahara ◽

S Maenohara ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Uric Acid ◽

Cardiovascular Risk ◽

General Population ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Body Mass ◽

Cardiovascular Risks ◽

Japanese General Population

Abstract Background The J-shaped association between serum uric acid (SUA) and cardiovascular risks is known. However, the bottom of the J-shaped curve has not been elucidated because of the lack of epidemiological knowledge about hypouricemia. Purpose To explore the SUA levels related to the most preferable cardiovascular risks using data from a Japanese general population. Methods Data from 246,923 individuals (111,117 men and 135,806 women) who underwent routine health checkups between January 2001 and December 2015 were analyzed. The participants were divided into quartiles according to their SUA levels, and patients with hypouricemia (SUA level <2.0 mg/dL) were subdivided into two groups according to their distributions. We compared their characteristics, including their cardiovascular risks. Results The prevalence of hypouricemia was 0.46% overall, 0.21% for men, and 0.66% for women (P<0.001). The subjects with hypouricemia were divided into two groups according to SUA level: a lower hypouricemia group (0.4–1.1 mg/dL, which included a peak at 0.7–0.8 mg/dL) and a higher hypouricemia group (1.4–2.0 mg/dL). The two groups exhibited significanly different characteristics in several variables: body mass index and triglyceride in men, and age, body mass index, triglyceride, low-density lipoprotein cholesterol, and renal function in women. Furthermore, several cardiovascular risk factors showed the most preferable values in subjects with SUA 1.4–2.0 mg/dL (Figure). Conclusions There were two independent distributions in subjects with SUA ≤2.0 mg/dL. The individuals with SUA 1.4–2.0 mg/dL exhibited the most preferable values for several cardiovascular risk factors, suggesting an association with the bottom of the J-shaped curve between SUA and cardiovascular risks.

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Genetics of Variation in Serum Uric Acid and Cardiovascular Risk Factors in Mexican Americans

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2008-0682 ◽

2009 ◽

Vol 94 (2) ◽

pp. 632-638 ◽

Cited By ~ 26

Author(s):

V. Saroja Voruganti ◽

Subrata D. Nath ◽

Shelley A. Cole ◽

Farook Thameem ◽

Jeremy B. Jowett ◽

...

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Mexican Americans

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SERUM URIC ACID, CARDIOVASCULAR DISEASE, AND ALL CAUSE MORTALITY; IMPACT OF GENDER, BLOOD PRESSURE, RENAL FUNCTION AND CARDIOVASCULAR RISK FACTORS. THE TROMSØ STUDY 1994/95: PP.7.268

Journal of Hypertension ◽

10.1097/01.hjh.0000378592.46140.c2 ◽

2010 ◽

Vol 28 ◽

pp. e130

Author(s):

H Storhaug ◽

I Toft ◽

T Melsom ◽

UD Mathisen ◽

MD Solbu ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Cardiovascular Disease ◽

Renal Function ◽

Uric Acid ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

All Cause Mortality

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ASSOCIATION BETWEEN SERUM URIC ACID LEVEL AND CARDIOVASCULAR RISK FACTORS AND THEIR CLUSTERING RISK IN CHILDREN AND ADOLESCENTS IN YINCHUAN CITY

Journal of Hypertension ◽

10.1097/01.hjh.0000749424.52139.76 ◽

2021 ◽

Vol 39 (Supplement 1) ◽

pp. e415

Author(s):

Rongrong Cai ◽

Yangyang Dong ◽

Jinyu Zhou ◽

Ling Bai ◽

Leina Jia ◽

...

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Risk ◽

Children And Adolescents ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level

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Prevalence of Hyperuricemia and its Association with Other Cardiovascular Risk Factors in Adult Yemeni People of Sana'a City

Clinical Cardiology and Cardiovascular Medicine ◽

10.33805/2639.6807.118 ◽

2019 ◽

pp. 10-14

Author(s):

Mohammed Ahmed Bamashmos ◽

Khaled Al-Aghbari

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Risk ◽

Total Cholesterol ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Density Lipoprotein

Objective: Hyperuricemia is a metabolic problem that has become increasingly common worldwide over the past several decades. Its prevalence is increased in both advanced and developing countries including Yemen. The aim of this cross sectional study was to investigate the prevalence of hyperuricemia in sample of Yemeni adult individual and its relationship to certain cardiovascular risk factors namely obesity, hypertension, serum glucose, total cholesterol, high serum triglyceride, Low High Density Lipoprotein (HDL-C) and high Low Density Lipoprotein (LDL-C). Methodology: A sample of 600 adult Yemeni people aged equal or over 18 years was randomly chosen to represent the population living in Sanaa City during a period of two years from April 2017 to August 2018. All the study groups undergo full clinical history and examination includes measurement of BP and BMI, WC and the following laboratory investigation (FBS, Basal serum uric acid level, total cholesterol, serum TG, HDL and LDL). Results: The prevalence of hyperuricemia in this study was 8.8% (11,6% male and 6.4% female). The serum uric acid level in this study was significantly correlated with age, Waist Circumference (WC), SBP, DBP, FBS, T-cholesterol, TG and LDL but not with HDL. Conclusion: There is strong relationship between serum uric acid level and other cardiovascular risk factors.

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