Association of family history with incidence and gestational hypertension outcomes of preeclampsia

Background: Predicting the potential risk factors of High blood pressure(HBP) among children and adolescents is still a knowledge gap. Our study aimed to establish and validate a nomogram-based model for identifying children and adolescents at risk of developing HBP based on a population-based prospective study.<br /> Methods: Hypertension was defined as systolic blood pressure or diastolic blood pressure above 95th percentile, using age, gender and height-specific cut-points. Penalized regression with Lasso was used to identify the strongest predictors of hypertension. Internal validation was conducted by 5-fold cross-validation and bootstrapping approach. The predictive variables were identified along with the advanced nomogram plot by conducting univariate and multivariate logistic regression analyses. A nomogram was constructed by training group comprised of 239,546(69.89%)participants and subsequently validated by externally group with 103,190(30.11%)participants.<br /> Results: Of 342,736 children and adolescents, a total of 55,480(16.19%) youths were identified with HBP with mean age 11.51±1.45 year and 183,487 were boys(53.5%). Nine significant relevant predictors were identified including: age, gender, weight status, birthweight, breastfeeding, gestational hypertension, family history of obesity, 46family history of hypertension and physical activity. An acceptable discrimination[Area under the receiver operating characteristic curve(AUC):0.742(Development group), 0.740(Validation group)] and good calibration(Hosmer and Lemeshow statistics, P ? 0.05) were observed in our models. An available web-based nomogram was built online.<br /> Conclusions: This model composed of age, gender, early life factors, family history of disease, and lifestyle factors may predict the risk of HBP among children and adolescents, which has developed a promising nomogram that may aid in more accurately for identifying the HBP among youths in primary care. <br />Funding Sources: The work was supported by the National Natural Science Foundation of China (No. 81673193).

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Folic Acid Supplement Use and Increased Risk of Gestational Hypertension

Hypertension ◽

10.1161/hypertensionaha.119.14621 ◽

2020 ◽

Vol 76 (1) ◽

pp. 150-156 ◽

Cited By ~ 1

Author(s):

Qian Li ◽

Shangzhi Xu ◽

Xi Chen ◽

Xu Zhang ◽

Xiating Li ◽

...

Keyword(s):

Folic Acid ◽

Family History ◽

Risk Ratio ◽

Gestational Hypertension ◽

Significant Risk ◽

High Dose ◽

Supplement Use ◽

Increased Risk ◽

History Of ◽

Family History Of Hypertension

Current results regarding the effect of folic acid (FA) supplement use on gestational hypertension (GH) and preeclampsia are limited and inconsistent. We aimed to investigate whether FA supplement use was associated with GH and preeclampsia. Participants from the Tongji Maternal and Child Health Cohort with information on periconceptional FA supplement use and diagnosis of GH/preeclampsia were included (n=4853). Robust Poisson regression was used to assess the association of FA supplement use and GH and preeclampsia. Among the 4853 participants in this study, 1161 (23.9%) and 161 (3.3%) women were diagnosed with GH and preeclampsia, respectively. The risk ratio of developing GH was higher in women who used ≥800 µg/d FA supplement from prepregnancy through midpregnancy than nonusers (risk ratio, 1.33 [1.08–1.65]). After adjusting for social-demographic, reproductive, lifestyle factors, family history of hypertension, other supplement use, and gestational weight gain, the adverse association remained significant (risk ratio, 1.32 [1.06–1.64]). Restricting the analysis among women with normal weight, without family history of hypertension, and without gestational diabetes mellitus, the positive FA-GH association still existed. We did not find any significant association between FA supplement use and preeclampsia regardless of adjustment. High-dose (≥800 µg/d) FA supplement use from prepregnancy through midpregnancy was associated with increased risk of GH. Attention should be given to avoid the potential risk of GH due to inappropriate FA supplement use in women who are planning or capable of pregnancy.

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The risk factors of gestational hypertension in patients with polycystic ovary syndrome: a retrospective analysis

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-03808-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shu Zhou ◽

Yiping Ji ◽

Haimei Wang

Keyword(s):

Risk Factors ◽

Family History ◽

Gestational Hypertension ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Contraceptive Pills ◽

History Of ◽

Independent Risk Factors ◽

Family History Of Hypertension ◽

Adverse Pregnancy

Abstract Background The hypertensive disorders complicating pregnancy (HDCP) is common in patients with polycystic ovary syndrome (PCOS), yet the potential influencing factors remained unclear. We aimed to assess the independent risk factors of HDCP in patients with PCOS, to provide clinical evidences for the management of PCOS. Methods Pregnant PCOS patients treated in our hospital from June 1, 2018 to November 30, 2020 were approached. The personal and clinical characteristics of patients with and without gestational hypertension were evaluated. Logistic regressions were conducted to identify the independent risk factors of HDCP, Receiver operating characteristics (ROC)curve analysis was conducted to evaluate the predicting value. Results A total of 188 PCOS patients were included, the incidence of HDCP in patients with PCOS was 27.66 %. There were significant differences in the age, BMI, family history of hypertension, the history of adverse pregnancy, history of contraceptive pills use and family history of HDCP between HDCP group and no-HDCP group (all p < 0.05), and there were no significant differences in the family history of diabetes, multiple pregnancy and long-term smoking history between HDCP group and no-HDCP group (all p > 0.05). Age ≥ 27y(OR2.048, 95 %CI1.121 ~ 3.208), BMI ≥ 24 kg/m2(OR1.463, 95 %CI1.069 ~ 2.011), family history of hypertension(OR2.129, 95 %CI1.093 ~ 3.042), the history of adverse pregnancy(OR2.435, 95 %CI1.264 ~ 4.085), history of contraceptive pills use(OR3.806, 95 %CI1.184 ~ 6.102), family history of HDCP(OR1.934, 95 %CI1.016 ~ 2.774) were the independent risk factors of HDCP in patients with PCOS (all p < 0.05). ROC curve analyses indicated that those factors had good predictive value on HDCP in PCOS patients. Conclusions The incidence of HDCP in PCOS patients is relatively high. In clinical practice, medical workers should carry out early prevention and intervention measures for these risk factors to reduce the incidence of HDCP.

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ROLE OF RISK FACTORS FOR ARTERIAL HYPERTENSION IN PREGNANT WOMEN

Complex Issues of Cardiovascular Diseases ◽

10.17802/2306-1278-2019-8-1-15-22 ◽

2019 ◽

Vol 8 (1) ◽

pp. 15-22

Author(s):

N. A. Bichan ◽

A. S. Rublevskaya ◽

A. E. Vlasenko ◽

N. A. Trofimenko ◽

O. I. Kriulkina

Keyword(s):

Risk Factors ◽

Family History ◽

Arterial Hypertension ◽

Pregnant Women ◽

Salt Intake ◽

Gestational Hypertension ◽

Overweight And Obesity ◽

Stepwise Logistic Regression ◽

Increased Risk ◽

History Of

Aim.To assess risk factors for arterial hypertension in pregnant women.Methods.The prevalence of risk factors for arterial hypertension (AH) was estimated in 240 pregnant women with arterial hypertension (AH) and 126 healthy pregnant women. Women with symptomatic or gestational hypertension or diabetes mellitus were excluded from the study. The following AH risk factors were assessed: age, family history, smoking, overweight/obesity, and excessive salt intake. Odds ratios were calculated utilizing stepwise logistic regression.Results.Pregnant women ≥32 years of age had 1.33-fold higher risk of AH in comparison with those <32 years of age. Hypertensive status of both parents or one of them was associated with 1.8- and 1.67-fold higher risk of AH as compared to patients without family history of AH. Smoking, overweight, and obesity increased risk of AH by a factor of 1.83, 1.74, and 2.24, respectively. Combination of age ≥32 years with obesity, family history of AH or smoking status further augmented risk of AH (2.46-, 2.18 or 2.14-fold, respectively) as compared to healthy pregnant women. Likewise, combination of AH family history with overweight or obesity resulted in 2.9- and 3.0-fold higher risk of AH. Combination of smoking with family history of AH, overweight, and obesity increased risk of AH by a factor of 2.95, 3.61, and 4.65, respectively. Amount of salt intake did not differ in pregnant women with and without AH.Conclusion.The estimated risk factors for AH are significant in pregnant women. Age over 32 years was associated with 1.33 OR for AH, family history with 1.8 OR, smoking with 1.83 OR, overweight with 1.7 OR, whereas obesity increased 2.24-fold odds for AH. Obesity and family history increased 2.9-fold odds for AH, whereas smoking and family history were associated with 3-fold increased odds for AH and combined with obesity up to 4.6-fold increased odds.

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Language Onset and Concomitant Speech and Language Problems in Subgroups of Stutterers and Their Siblings

Journal of Speech Language and Hearing Research ◽

10.1044/jshr.2504.482 ◽

1982 ◽

Vol 25 (4) ◽

pp. 482-486 ◽

Cited By ~ 12

Author(s):

Robin A. Seider ◽

Keith L. Gladstien ◽

Kenneth K. Kidd

Keyword(s):

Family History ◽

Same Sex ◽

Speech And Language ◽

Negative Family History ◽

Late Talkers ◽

Language Problems ◽

History Of ◽

Language Onset

Time of language onset and frequencies of speech and language problems were examined in stutterers and their nonstuttering siblings. These families were grouped according to six characteristics of the index stutterer: sex, recovery or persistence of stuttering, and positive or negative family history of stuttering. Stutterers and their nonstuttering same-sex siblings were found to be distributed identically in early, average, and late categories of language onset. Comparisons of six subgroups of stutterers and their respective nonstuttering siblings showed no significant differences in the number of their reported articulation problems. Stutterers who were reported to be late talkers did not differ from their nonstuttering siblings in the frequency of their articulation problems, but these two groups had significantly higher frequencies of articulation problems than did stutterers who were early or average talkers and their siblings.

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